Erectile dysfunction and sex hormone changes in chronic obstructive pulmonary disease patients

Kahraman, Hasan; Sen, Bilal; Köksal, Nurhan; Kılınç, Metin; Resim, Sefa

doi:10.4081/mrm.2013.578

Cited by 15 publications

(25 citation statements)

References 21 publications

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“…Consistent with this, increased daytime sleepiness, decreased total sleep time, decreased sleep efficiency, and levels of fatigue have been reported during an exacerbation [54,55]. In addition, COPD has previously been associated with sexual dysfunction in males, particularly erectile dysfunction, with most patients dissatisfied with their current and expected sexual function [56,57]. How COPD exacerbations affect sexual functioning has not yet been fully elucidated, but sex hormone levels have been shown to be markedly altered during a COPD exacerbation [58], which may have resulted in sexual dysfunction.…”

Section: Effect On Quality Of Life and Physical Activitysupporting

confidence: 57%

Understanding the impact of chronic obstructive pulmonary disease exacerbations on patient health and quality of life

Hurst

Skolnik

Hansen

et al. 2020

European Journal of Internal Medicine

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Exacerbations of chronic obstructive pulmonary disease (COPD) represent a significant clinical problem, and are associated with decreased lung function, worsening quality of life and decreased physical activity levels, with even a single exacerbation having detrimental effects. The occurrence of COPD exacerbations can also have a considerable impact on healthcare costs and mortality rates, with over one-fifth of patients hospitalized for a COPD exacerbation for the first time dying within one year of discharge. This highlights the need for COPD exacerbations to be a major focus in clinical practice. Furthermore, the substantial effect that COPD exacerbations can have on patient mental health should not be underestimated. Despite their clinical importance, COPD exacerbations are poorly recognized and reported by patients, and improving patient understanding and reporting of exacerbations to ensure prompt treatment may minimize their deleterious effects. Renewed focus on improving current clinical practice with support from evidence-based guidelines is required. This also raises a challenge to payors, healthcare systems and government policies to do more to tackle the considerable outstanding burden of COPD exacerbations. Search methodsRelevant articles for this non-systematic, narrative literature review were identified via PubMed searches and from author knowledge. Only articles published in English were included.

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Section: Effect On Quality Of Life and Physical Activitysupporting

confidence: 57%

Understanding the impact of chronic obstructive pulmonary disease exacerbations on patient health and quality of life

Hurst

Skolnik

Hansen

et al. 2020

European Journal of Internal Medicine

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“…In addition, a direct correlation between testosterone level and the severity of COPD has been observed (Vertkin, 2013). In a study comprising 70 patients with COPD, prevalent erectile dysfunction and lower testosterone level were observed, but the difference in testosterone level was not statistically significant compared with the control group (Kahraman et al, 2013). Metaanalysis of 2918 patients in nine studies involving patients with COPD, testosterone concentration was lower than in control groups.…”

Section: Discussionmentioning

confidence: 88%

Detection of Late-Onset Hypogonadism in Men with Chronic Internal Diseases

Požarskis

Lejnieks

2019

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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Late-onset hypogonadism (LOH) is a clinical and biochemical syndrome associated with age and featured by typical symptoms and reduced blood testosterone level. Among males aged over 30 years, the incidence of androgen deficiency is 7 to 30%. The aim of this study was to investigate the incidence of hypogonadism in patients aged over 40 years with an underlying condition and/or a comorbidity, such as arterial hypertension, Chronic obstructive pulmonary disease (COPD), metabolic syndrome, Type 2 of diabetes mellitus, dyslipidaemia, adiposity in various General practice (GP) and physician-sexologists’ offices in Latvia, and to determine the influence of chronic diseases on the development of hypogonadism. Males aged 39 years who turned to family doctors at nine GP were offered to fill in Aging Male Study (AMS) questionnaires used for the diagnostics of late-onset hypogonadism. Males aged 40 years who visited the office of the physician sexologist Anatolijs Požarskis were offered to fill in the same questionnaires. After compiling the data from AMS questionnaires, a group of males exhibiting signs of LOH were isolated (in total 1222 persons). In these patients, we determined blood testosterone and sex-hormone binding globulin (SHBG) levels. Chronic diseases were found in these men in data evaluation of patient medical records, and after performing physical and laboratory examinations. Late-onset hypogonadism was laboratory-diagnosed in 79% of patients with signs of late-onset hypogonadism in accordance with the AMS questionnaires and with concomitant diseases and in 4.7% of patients with signs of late-onset hypogonadism in accordance with the AMS questionnaires and without the aforementioned concomitant diseases. Persons with arterial hypertension, dyslipidaemia, adiposity, metabolic syndrome, COPD and Type 2 of diabetes mellitus had higher chance of developing hypogonadism (p < 0.001). Arterial hypertension, dyslipidaemia, adiposity, metabolic syndrome, COPD statistically significantly (p < 0.001) decreased the level of total testosterone by 0.47, 1.18, 0.36, 0.67, and 0.18 ng/ml, respectively, and decreased the level of free testosterone by 2.52, 2.71, 1,69, 6.77, and 4.58 pg/ml, respectively. Type 2 diabetes mellitus had no statistically significant effect on the level of total and free testosterone (p = 0.95, p = 0.10). The most significant decrease in the level of testosterone was observed in cases of dyslipidemia, COPD and metabolic syndrome. General physicians should pay special attention to patients with this disease, as these patients belong to a group with a high risk of development of expressed LOH syndrome.

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“…Most (80%) of those with COPD had problems with their erections, whist the rate in those without a COPD diagnosis was 56%. 7 In a later article by Shen et al, over 29,000 males with COPD age and index year matched with the controls found the incidence of ED was 1.88-fold higher in the COPD population, but they had more prevalent morbidities such as diabetes, depression and anxiety, and poor control of COPD was a key factor in ED development so those with more emergency visits and admissions were more likely to have ED. 2 In this issue, Turan et al remind us that sexual problems, inclusive of ED are not commonly addressed by health professionals.…”

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confidence: 97%