Erectile Dysfunction and Obstructive Sleep Apnea: A Review

Gu, Yiwei; Wu, Changjing; Qin, Feng; Yuan, Jing

doi:10.3389/fpsyt.2022.766639

Cited by 6 publications

(4 citation statements)

References 81 publications

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“…Adverse sleep patterns have significant public health implications. Numerous studies have investigated the correlation between sleep traits, such as insomnia and obstructive sleep apnea (OSA), and the risk of ED [7][8][9]. A large cross-sectional observational study conducted in the Chinese population supports the findings of a Taiwanese population-based cohort study.…”

Section: Introductionmentioning

confidence: 79%

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Causal relationship between sleep traits and erectile dysfunction: Evidence from Mendelian Randomization analysis

Zhu,

Gao,

Guo

et al. 2024

Arch Med Sci

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IntroductionAlthough several observational studies have explored the association between sleep traits and the risk of erectile dysfunction (ED), it remains controversial. In the present study, we included a wide range of sleep traits that are commonly observed in clinical practice. We investigated the causal relationship between these sleep traits and ED using univariate and multivariate Mendelian randomization (MR) methods.Material and methodsInstrumental variables (IVs) for eight sleep traits (insomnia, sleep duration, chronotype, and sleep apnea syndrome), five confounders (depression, body mass index, smoking initiation, alcohol consumption, and type 2 diabetes), and ED were derived from genome-wide association study (GWAS) data of individuals of European ancestry. The primary analysis technique used was the inverse-variance weighted (IVW) approach. Furthermore, several sensitivity analyses were conducted to evaluate heterogeneity, horizontal pleiotropy, and stability.ResultsMR analysis revealed that increased snoring, short sleep, and frequent insomnia, were associated with a higher risk of ED. Furthermore, we found evidence of a significant association between being a morning person and the risk of developing ED. This association persisted in multivariable MR analyses after adjusting for potential confounding factors. Sensitivity analysis suggested that the results were robust with no evidence of pleiotropy or heterogeneity.ConclusionsThis study provides further evidence supporting the association between genetically predicted snoring, insomnia, and an increased risk of ED. Additionally, the study highlights the causal relationship of short sleep duration and chronotype with ED.

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Section: Introductionmentioning

confidence: 79%

“…Some studies have reported that OSA is not associated with ED [34,35]. Another study reported a strong correlation between the severity of OSA and decreased sexual satisfaction, but no significant association with ED [8]. Continuous positive airway pressure (CPAP) and surgical treatments were demonstrated as effective therapies for OSA.…”

Section: Discussionmentioning

confidence: 99%

Causal relationship between sleep traits and erectile dysfunction: Evidence from Mendelian Randomization analysis

Zhu,

Gao,

Guo

et al. 2024

Arch Med Sci

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“…сочетание избыточного веса/ожирения с Аг предполагает наличие эд различной степени тяжести [84]. сочетание эд с ожирением и обструктивным апноэ сна увеличивает риск сердечнососудистых заболеваний и их осложнений [85]. кроме того, существует сильная взаимосвязь между симптомами нижних мочевых путей и эд [86].…”

Section: результатыunclassified

Sexual dysfunction in men and women with arterial hypertension

Kanorskii

2024

jour

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Sexual dysfunction is often associated with hypertension but is not recognized, reported, or adequately treated. Research on sexual dysfunction is sparse, which may be due to the taboo nature of the topic. A literature search was conducted in five databases (PubMed, Web of Science, Scopus, Cochrane Library and PsycINFO) to identify articles published over the past ten years (from 2014 to 2024), using the keywords “sexual dysfunction”, “arterial” hypertension", "antihypertensive drugs", "erectile dysfunction". The review examines the prevalence, pathophysiology, clinical manifestations of sexual dysfunction in men and women, its relationship with arterial hypertension, antihypertensive therapy, concomitant pathology, and possible methods of correction.

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“…In men aged younger than 65 years, only severe OSA is linked with ED; however, for men aged 65 years and older, ED is associated with both moderate and severe OSA ( 102 ). It is important to consider the presence of OSA in men with ED, obesity, and hypertension ( 104 ) and/or symptoms of depression ( 105 ). Treatment with CPAP has been reported to variably have no effect ( 106 ) or improve ( 107-109 ) erectile function, a benefit enhanced by PDE5 inhibitors ( 109 ).…”

Section: Pathophysiology and Associations Of Osa With Other Disordersmentioning

confidence: 99%

Approach the Patient With Obstructive Sleep Apnea and Obesity

Meyer,

Wittert

2023

The Journal of Clinical Endocrinology &Amp; Metabolism

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Obstructive sleep apnoea (OSA) and obesity are highly prevalent and bidirectionally associated. OSA is however underrecognized, particularly in women. By mechanisms that overlap with those of obesity, OSA increases the risk of developing, or having poor outcomes from, comorbid chronic disorders and impairs quality of life. Using two illustrative cases we discuss the relationships between OSA and obesity with type 2 diabetes, dyslipidemia, cardiovascular disease, cognitive disturbance, mood disorders, lower urinary tract symptoms, sexual function, and reproductive disorders. The differences in OSA between men and women, the phenotypic variability of OSA, and co-morbid sleep disorders are highlighted. When the probability of OSA is high due to consistent symptoms, comorbidities, or both, a diagnostic sleep study is advisable. Continuous positive airway pressure or mandibular advancement splints improve symptoms. Benefits for comorbidities are variable depending on nightly duration of use. By contrast weight loss and optimization of lifestyle behaviors are consistently beneficial.

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Erectile Dysfunction and Obstructive Sleep Apnea: A Review

Cited by 6 publications

References 81 publications

Causal relationship between sleep traits and erectile dysfunction: Evidence from Mendelian Randomization analysis

Causal relationship between sleep traits and erectile dysfunction: Evidence from Mendelian Randomization analysis

Sexual dysfunction in men and women with arterial hypertension

Approach the Patient With Obstructive Sleep Apnea and Obesity

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