Erectile dysfunction and angiographic extent of coronary artery disease in type II diabetic patients

Abstract

Some studies observed an association between erectile dysfunction (ED) and coronary artery disease (CAD) extent in the general population, but others did not. There are no specific studies in diabetic populations. The aim of the present study was to evaluate whether ED is correlated with the extent of angiographic CAD in a large group of type II diabetic patients. We recruited 198 consecutive type II diabetic males undergoing an elective coronary angiography to evaluate chest pain or suspected CAD. Presence and degree of ED were assessed by the International Index Erectile Function -5 (IIEF-5) questionnaire. ED was considered present, when IIEF-5 score was p21. Moreover, each domain of IIEF-5 was considered. Angiographic CAD extent was expressed both by the number of vessels diseased and by the Gensini scoring system. The percentage of subjects with ED was significantly higher (45.8 versus 15.8%; P ¼ 0.0120) in patients with (n ¼ 179) than in those without (n ¼ 19) significant angiographic CAD (stenosis of the lumen X50%). No significant association of CAD extent with presence of ED, total IIEF-5 score and each domain of IIEF-5 was observed. Our study shows that ED was significantly more prevalent in type II diabetic males with angiographic CAD than in those with normal arteries. However, no correlation was found between the extent of angiographic CAD and the presence or the severity of ED.

Erectile dysfunction can improve the effectiveness of the current guidelines for the screening for asymptomatic coronary artery disease in diabetes

“…The echo-stress was considered negative if no regional wall motion abnormalities were observed. In patients with highly positive ECG (n = 11), in those with a positive scintigraphy (n = 61) and in those with a positive dipiridamole stress testing (n = 8) a diagnostic coronary angiography was recommended and performed as previously reported [21]. An atherosclerotic lesion was considered significant when a stenosis C50% of the lumen in at least one major vessel was documented.…”

Cutaneous microcirculatory function predicts the responsiveness to tadalafil in patients with erectile dysfunction and coronary artery disease

“…[1][2][3] Studies on the flow-mediated vasodilation of the brachial artery, which is a reproducible measure of endothelial health and function, have pointed out impaired vasodilatory capacity in both, patients with ED 10,11 or CAD. 15,33,34 Consequently, striking evidence for a close clinical association of ED and CAD has accumulated, [35][36][37] in which ED seems to precede CAD. 38 The use on demand of a PDE5i can produce sustained improvements in erectile function.…”

The association of glomerular filtration rate and erectile dysfunction with severity of coronary artery disease in patients presenting with chest pain

“…The same cardiovascular risk factors that are associated with CAD are also associated with endothelial dysfunction and atherosclerosis of blood vessels that supply the penis. Previous studies have consistently shown that the severity and extent of CAD are associated with the presence and severity of ED [7][8][9]. Chronic kidney disease is also associated with inflammation and subsequently with endothelial dysfunction syndrome [10].…”