Erectile Dysfunction and Anejaculation

Schultheiss, Dirk; Schlote, Norbert; Stief, Christian G.; Jonas, Udo

doi:10.1159/000020127

Cited by 2 publications

(2 citation statements)

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“…During the administration of sildenafil or iNO, more preterm lambs demonstrated a positive functional response with increased ΔoxyHb following nerve stimulations, compared to the control lambs (Table 2). Sildenafil is reported to enhance the cerebral haemodynamic response to auditory and visual stimulations in adult humans (Schultheiss et al, 2001;Lindberg et al, 2017). Studies of other phosphodiesterase-5 inhibitors in adults also report improved responsiveness of the cerebral vasculature, particularly in disease states associated with impaired cerebral vasoreactivity (Pauls et al, 2018).…”

Section: During Somatosensory Stimulationsmentioning

confidence: 99%

“…Interestingly, sildenafil has been reported to enhance event-or task-related EEG potentials in healthy adults (Schultheiss et al, 2001). Moreover, inhibition of nitric oxide synthase attenuates the cortical SEP as well as the cerebrovascular functional response during somatosensory stimulation (Ngai et al, 1995;Ngai et al, 1998).…”

Section: During Somatosensory Stimulationsmentioning

confidence: 99%

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Cerebral haemodynamic response to somatosensory stimulation in preterm lambs is enhanced following sildenafil and inhaled nitric oxide administration

et al. 2023

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Background: Neurovascular coupling (NVC) leads to an increase in local cerebral blood flow and oxygenation in response to increased neural activity and metabolic demand. Impaired or immature NVC reported in the preterm brain, potentially reduces cerebral oxygenation following increased neural activity, predisposing to cerebral tissue hypoxia. Endogenous nitric oxide (NO) is a potent vasodilator and a major mediator of NVC and the cerebral haemodynamic response. NO modulators, such as inhaled nitric oxide (iNO) and sildenafil, induce vasodilation and are used clinically to treat pulmonary hypertension in preterm neonates. However, their impact on NVC in the preterm brain are unknown. We aimed to characterise the cerebral functional haemodynamic response in the preterm brain exposed to NO modulators. We hypothesized that iNO and sildenafil in clinical dosages would increase the baseline cerebral perfusion and the cerebral haemodynamic response to neural activation.Methods: Preterm lambs (126–7 days’ gestation) were delivered and mechanically ventilated. The cerebral functional haemodynamic response was measured using near infrared spectroscopy as changes in cerebral oxy- and deoxyhaemoglobin (ΔoxyHb, ΔdeoxyHb), following left median nerve stimulations of 1.8, 4.8, and 7.8 s durations in control preterm lambs (n = 11), and following 4.8 and 7.8 s stimulations in preterm lambs receiving either sildenafil citrate (n = 6, 1.33 mcg/kg/hr) or iNO (n = 8, 20 ppm).Results: Following 1.8, 4.8, and 7.8 s stimulations, ∆oxyHb in the contralateral cortex increased (positive functional response) in 7/11 (64%), 7/11 (64%), and 4/11 (36%) control lambs respectively (p < 0.05). Remaining lambs showed decreased ΔoxyHb (negative functional response). Following 4.8 s stimulations, more lambs receiving sildenafil or iNO (83% and 100% respectively) showed positive functional response compared to the controls (p < 0.05). No significant difference between the three groups was observed at 7.8 s stimulations.Conclusion: In the preterm brain, prolonged somatosensory stimulations increased the incidence of negative functional responses with decreased cerebral oxygenation, suggesting that cerebral oxygen delivery may not match the oxygen demand. Sildenafil and iNO increased the incidence of positive functional responses, potentially enhancing NVC, and cerebral oxygenation.

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Section: During Somatosensory Stimulationsmentioning

confidence: 99%