Erectile dysfunction

Shamloul, Rany; Ghanem, Hussein

doi:10.1016/s0140-6736(12)60520-0

Cited by 862 publications

(806 citation statements)

References 130 publications

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“…Inhibition of this enzyme ultimately leads to the maintenance of lower levels of intracellular calcium, with smooth muscle relaxation and vasodilation. Drugs such as sildenafil, vardenafil and tadalafil, have been widely used in humans for the treatment of erectile dysfunction since 1998 13 .…”

Section: ■ Discussionmentioning

confidence: 99%

Tadalafil protector effect during ischemia-reperfusion in rats

et al. 2017

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Tadalafil protector effect during ischemia-reperfusion in rats 1 9-Experimental SurgeryActa Cir Bras. 2017;32(11):973-983 AbstractPurpose: To evaluate histological parameters in rat renal tissue after tadalafil use during hot ischemia for 45 minutes and reperfusion for 24 hours. Methods: Twenty rats were divided into 2 groups. In the experimental group 10 mg/ kg of tadalafil was used per gavage before the procedure. All cases underwent left partial nephrectomy, followed by 45 minutes of warm ischemia. Left nephrectomy of the remaining kidney was performed after 24 hours from the initial procedure. The histological parameters analyzed were: detachment of tubular cells, accumulation of desquamated cells in the proximal tubule, loss of brush border, tubular cylinders, interstitial edema, leukocyte infiltration, capillary congestion, vacuolization, tubular dilatation, necrosis and collapse of the capillary tuft. Results: Two rats from each group died and were excluded from the study. Tadalafil significantly reduced leukocyte infiltration (p = 0.036). The remaining histological parameters did not show statistical difference between the groups. Conclusion: The use of tadalafil during warm ischemia and reperfusion demonstrates statistically significant reduction of leukocyte infiltration in the renal interstitium. 973Tadalafil protector effect during ischemia-reperfusion in rats Wietzikoski EGG et al. Acta Cir Bras. 2017;32(11):973-983 974

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Section: ■ Discussionmentioning

confidence: 99%

Tadalafil protector effect during ischemia-reperfusion in rats

et al. 2017

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“…[1][2][3][4] It is important therefore to reinforce the importance of adopting a healthy lifestyle, which will also improve general cardiovascular health. The beneficial effects of weight loss on erectile function are more profound in obese nondiabetic men than men with diabetes.…”

Section: Management (See Figure 1)mentioning

confidence: 99%

“…1 The prevalence of ED ranges from 2 to 9 per cent in men between 40 and 49 years, 20-40 per cent between 60 and 69 years and 50-100 per cent over 70 years. 2 While in the past poor understanding of its aetiology, social taboo and lack of effective treatment options were considered barriers to managing this major health problem in men, today it is more widely and openly discussed.…”

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confidence: 99%

“…There is now mounting evidence that ED is associated with an increased risk of coronary artery disease (CAD), stroke and all-cause mortality. 2,3 This could be because they share the same risk factors and pathophysiological mechanisms such as endothelial dysfunction and chronic inflammation, vascular structural alterations, dysfunctional nitrous oxide (NO) pathways and abnormal peripheral sympathetic activity.…”

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confidence: 99%

“…2 Common unhealthy lifestyle factors such as smoking, obesity and lack of physical exercise have also been shown to be important predictors in the development of ED. [1][2][3][4] In this article, we provide an outline of the aetiology, assessment and management of ED in primary care.…”

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confidence: 99%

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Erectile dysfunction: assessment and management in primary care

Rajendran¹,

Cummings²

2014

Prescriber

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Assessing Sexual Dysfunction, Part 1: Male Sexual Dysfunction

Cohen¹,

Mandel²,

Samadi³

2016

AMA Guides® Newsletter

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To properly assess men and women with sexual dysfunction, evaluators should take a biopsychosocial approach that may require consultation with multiple health care professionals from various fields in order to get to the root of the sexual dysfunction; this multidisciplinary methodology offers the best chance of successful treatment. For males, this article focuses on erectile dysfunction (ED) and hypogonadism. The initial evaluation of ED involves a thorough case history, preferably taken from the patient and partner, physical examination, and proper laboratory and diagnostic tests, including an acknowledgment of the subjective complaint. The diagnosis is established on the basis of an individual's report of the consistent inability to attain and maintain an erection sufficient to permit satisfactory sexual intercourse. Initial workups for ED should entail a detailed history that can be obtained from a validated questionnaire such as the International Index of Erectile Function and the Sexual Health Inventory for Men. Hypogonadism is evaluated using the validated Androgen Deficiency in the Aging Male questionnaire and laboratory testing for testosterone deficiency. Treatments logically can begin with the least invasive and then progress to more invasive strategies after appropriate counseling. The last and most important treatment component when caring for men with sexual dysfunction—and, arguably, the least practiced—is close follow-up.

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Erectile dysfunction

Cited by 862 publications

References 130 publications

Tadalafil protector effect during ischemia-reperfusion in rats

Tadalafil protector effect during ischemia-reperfusion in rats

Erectile dysfunction: assessment and management in primary care

Assessing Sexual Dysfunction, Part 1: Male Sexual Dysfunction

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