Erdheim-Chester disease: CT findings of thoracic involvement

Brun, Anne-Laure; Touitou-Gottenberg, Diane; Haroche, Julien; Tolédano, Dan; Cluzel, Philippe; Beigelman-Aubry, Cathérine; Piette, Jean‐Charles; Amoura, Zahir; Greniér, Philippe

doi:10.1007/s00330-010-1830-7

Cited by 74 publications

(78 citation statements)

References 29 publications

(39 reference statements)

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“…As a result, the most frequent cardiovascular evidence is periaortic circumferential tissue infiltration, known as a coated aorta. [7][8][9] The aortic effects and fibrosis can extend from the ascending aorta down to the iliac bifurcation or be limited to the thoracic or abdominal aorta. 5 Unlike Takayasu arteritis and retroperitoneal f ibrosis, ECD infiltrates the periadventitial or perivascular area circumferentially, regularly forming a tissue with the same attenuation as muscle.…”

Section: Fig 2 Multidetector Computed Tomographic Images A) Reformamentioning

confidence: 99%

“…13 Fewer than 45 cases of ECD have been reported in association with coronary artery involvement. 5,8,9,[14][15][16] The cardiovascular manifestations of ECD are being detected more frequently because of improved imaging techniques, indicating that the number of such cases has been underestimated. Currently, the best images and low radiation doses are produced by 256-slice, dualsource MDCT, prospectively ECG-triggered acquisition, and a high pitch value of 3.2 or 3.4.…”

Section: Fig 2 Multidetector Computed Tomographic Images A) Reformamentioning

confidence: 99%

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Multidetector Computed Tomographic Imaging of Erdheim-Chester Disease

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Karabulut

et al. 2014

Texas Heart Institute Journal

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E rdheim-Chester disease (ECD) is a rarely reported form of multisystemic, non-Langerhans-cell histiocytosis. The clinical manifestations range from no symptoms to life-threatening conditions. Involvement of the bones, lungs, retro-orbital space, perirenal space, nervous system, cardiovascular system, and skin has particularly been observed. The cardiovascular involvement of ECD is probably more frequent than was originally thought; technological advances in multidetector computed tomography (MDCT) have enabled better views of patients' coronary arteries at low radiation doses. We report the case of a young woman in whom we used 256-slice, dual-source MDCT with high pitch value to evaluate the coronary arteries and reveal the effects of ECD. Case ReportIn April 2013, a previously healthy 29-year-old woman was referred to our hospital with a 3-month history of progressive angina. She had no history of other medical illnesses or familial diseases. Results of physical examination, laboratory tests, electrocardiography (ECG), and echocardiography were normal. To analyze her coronary arteries, we used a 256-slice Somatom ® Definition Flash MDCT system (Siemens Medical Solutions; Forchheim, Germany) with a high pitch value of 3.2. The patient's effective radiation dose was 1.1 mSv for the cardiac imaging. The MDCT angiogram revealed large mediastinal soft tissue with muscle attenuation surrounding the ascending aorta, extending into the proximal segment of the left main coronary artery, and causing stenosis by compressing the proximal segment of the left anterior descending coronary artery (Figs. 1 and 2). This periaortic effect resembles "coated aorta," associated with ECD. A specimen from a computed tomographic-guided biopsy of the mediastinal mass displayed fibrosis and many foamy histiocytes (CD68 + and CD1a -). The imaging and histologic findings supported the diagnosis of ECD. Skeletal radiographs showed no bone involvement, and thoracoabdominal computed tomograms and magnetic resonance images of the brain and orbit revealed no effect on those organs. The patient was referred for hemato-oncologic treatment. She was subsequently lost to follow-up. DiscussionTo our knowledge, this is the first report of the use of low-dose, dual-source, 256-slice multidetector computed tomography to characterize Erdheim-Chester disease

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Section: Fig 2 Multidetector Computed Tomographic Images A) Reformamentioning

confidence: 99%

Section: Fig 2 Multidetector Computed Tomographic Images A) Reformamentioning

confidence: 99%

Multidetector Computed Tomographic Imaging of Erdheim-Chester Disease

Yüceler

Kantarcı

Karabulut

et al. 2014

Texas Heart Institute Journal

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“…Los histiocitos circulantes y del sitio de la lesión expresan un patrón de citokinas y quemokinas caracterizado por la elevación de interferón α, interleukina 6, interleukina 12 y MCP-1 3,4,10 .…”

Section: Discussionunclassified

“…Frecuentemente existe compromiso cardiovascular, que puede ser asintomático y detectarse en RM y/o scanner [2][3][4] . Las anormalidades más frecuentes son: a) recubrimiento de la aorta por un manguito de tejido-pudiendo comprometer sus ramas; b) infiltración pericárdica, que puede manifestarse por pericarditis, derrame pericárdico, taponamiento cardiaco o pericarditis constrictiva.…”

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“…Las anormalidades más frecuentes son: a) recubrimiento de la aorta por un manguito de tejido-pudiendo comprometer sus ramas; b) infiltración pericárdica, que puede manifestarse por pericarditis, derrame pericárdico, taponamiento cardiaco o pericarditis constrictiva. Menos frecuentemente se observa: c) infiltración miocár-dica-pudiendo originar insuficiencia cardiaca; d) infiltración de la aurícula derecha semejando un tumor cardiaco; e) infiltración de los sulcus aurículo-ventriculares, septum interauricular y lecho peri-coronario-pudiendo originar infartos; f) valvulopatías aórtica y mitral-produciendo regurgitación; g) anormalidades de la conducción o arritmias [3][4][5][6] . La falla cardiaca inducida por la fibrosis miocárdica y/o el compromiso pericárdico son las principales causas de muerte 7 .…”

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