ERCP induced and non-ERCP-induced acute pancreatitis: Two distinct clinical entities?

Zitinic, Ivana; Plavsic, Ivana; Poropat, Goran; Hauser, Goran

doi:10.1016/j.mehy.2018.02.017

Cited by 8 publications

(7 citation statements)

References 20 publications

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“…La mayoría de los pacientes con pancreatitis presentan episodios leves que se autolimitan 1,14 . Aquellos con episodios moderadamente graves y graves podrían llegar a presentar morbilidad considerable y aumentar la mortalidad 4,14 . Es muy parecido a lo que se reporta para la pancreatitis aguda por otras causas 23 .…”

Section: Discussionunclassified

“…El mecanismo por el que se presenta la pancreatitis pos-CPRE (PPCPRE) no está del todo comprendido, pero se sugiere que podría ser multifactorial 2,3 . Se piensa que podría representar una pancreatitis aguda diferente de la ocasionada por otras etiologías, con base en el patrón de la elevación de las enzimas pancreáticas, las manifestaciones clínicas y el peor pronóstico cuando se presenta en su forma grave 3,4 .…”

Section: Introductionunclassified

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Utilidad de la amilasa y la lipasa séricas como predictores de gravedad en la pancreatitis poscolangiopancreatografía retrógrada endoscópica

Martínez-Segundo¹,

Pinto-Angulo²,

García-Álvarez

et al. 2020

CIRU

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Section: Discussionunclassified

Section: Introductionunclassified

Utilidad de la amilasa y la lipasa séricas como predictores de gravedad en la pancreatitis poscolangiopancreatografía retrógrada endoscópica

Martínez-Segundo¹,

Pinto-Angulo²,

García-Álvarez

et al. 2020

CIRU

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“…Only a few studies mentioned the overall survival of patients with pancreatic cancer complicated by AP, and as a result, the impact of AP on tumor-specific survival has not been sufficiently elucidated. A recent study investigated whether an initial clinical presentation with AP was associated with the survival of patients with PDAC, but the results did not show any survival difference[3]. However, it is still difficult to draw firm conclusions.…”

Section: Discussionmentioning

confidence: 99%

“…There are multiple etiological factors involved in the development of acute pancreatitis (AP). Excluding common etiologies, such as alcohol and gallstones, the onset of AP may be due to cancer progression itself or to complications of the diagnostic and therapeutic interventional procedures used in pancreatic ductal adenocarcinoma (PDAC) treatment, such as endoscopic retrograde cholangiopancreatography (ERCP), surgery and chemotherapy[1-3]. PDAC often presents initially as AP[4-6].…”

Section: Introductionmentioning

confidence: 99%

Recurrence and survival after surgery for pancreatic cancer with or without acute pancreatitis

Qian¹,

Li²,

Zhang³

et al. 2019

WJG

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BACKGROUNDIn pancreatic cancer, acute pancreatitis (AP) is a serious morbidity, but its negative effect on long-term outcomes remains to be elucidated.AIMTo investigate the effects of AP on the tumor recurrence pattern of pancreatic ductal adenocarcinoma (PDAC) and tumor-specific survival.METHODSThe medical records of 219 patients with curative pancreatectomy for pancreatic cancer at the Pancreatic Surgery Center of West China Hospital from July 2012 to December 2016 were analyzed retrospectively. The severity of acute pancreatitis was classified according to the Atlanta classification of AP. The patient demographics and tumor characteristics were assessed. Early recurrence was defined as a relapse within 12 mo after surgery. Overall and disease-free survival and recurrence patterns were analyzed. Mild acute pancreatitis was excluded because its negative effects can be negligible.RESULTSEarly recurrence in AP group was significantly higher than in non-AP group (71.4% vs 41.2%; P = 0.009). Multivariate analysis of postoperative early recurrence showed that moderate or severe AP was an independent risk factor for an early recurrence [odds ratio (OR): 4.13; 95% confidence interval (CI): 1.41-12.10; P = 0.01]. The median time to recurrence was shorter in patients with AP than in those without (8.4 vs 12.8 mo; P = 0.003). Multivariate analysis identified AP as an independent prognostic factor for overall survival [relative risk (RR): 2.35; 95%CI: 1.45-3.83] and disease-free survival (RR: 2.24; 95%CI: 1.31-3.85) in patients with PDAC.CONCLUSIONPatients with moderate or severe acute pancreatitis developed recurrences earlier than those without. Moderate or severe AP is associated with shorter overall and disease-free survival of patients with PDAC.

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“…Direct comparison of the initial inflammatory response between PEP and non-ERCP AP would be of significant importance to clarify these statements. Found difference in clinical response to initial injury might be explained by different initial immune response[ 59 ].…”

Section: Immune Componentsmentioning

confidence: 99%

Endoscopic retrograde cholangiopancreatography-induced and non-endoscopic retrograde cholangiopancreatography-induced acute pancreatitis: Two distinct clinical and immunological entities?

Plavsic

Zitinic

Mikolašević

et al. 2018

WJGE

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Acute pancreatitis (AP) is common gastrointestinal disease of varied aetiology. The most common cause of AP is gallstones, followed by alcohol abuse as an independent risk factor. With the increased need for invasive techniques to treat pancreatic and bile duct pathologies such as endoscopic retrograde cholangiopancreatography (ERCP), AP has emerged as the most frequent complication. While severe AP following ERCP is rare (0.5%), if it does develop it has a greater severity index compared to non-ERCP AP. Development of a mild form of AP after ERCP is not considered a clinically relevant condition. Differences in the clinical presentation and prognosis of the mild and severe forms have been found between non-ERCP AP and post-endoscopic pancreatitis (PEP). It has been proposed that AP and PEP may also have different immunological responses to the initial injury. In this review, we summarise the literature on clinical and inflammatory processes in PEP vs non-ERCP AP.

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ERCP induced and non-ERCP-induced acute pancreatitis: Two distinct clinical entities?

Cited by 8 publications

References 20 publications

Utilidad de la amilasa y la lipasa séricas como predictores de gravedad en la pancreatitis poscolangiopancreatografía retrógrada endoscópica

Utilidad de la amilasa y la lipasa séricas como predictores de gravedad en la pancreatitis poscolangiopancreatografía retrógrada endoscópica

Recurrence and survival after surgery for pancreatic cancer with or without acute pancreatitis

Endoscopic retrograde cholangiopancreatography-induced and non-endoscopic retrograde cholangiopancreatography-induced acute pancreatitis: Two distinct clinical and immunological entities?

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