ERCC1, COX-2, and p53 Expression in Patients with Locally Advanced Cervical Cancer Treated with Chemoradiotherapy and Celecoxib: A Quantitative Immunohistochemical Analysis of RTOG 0128

Doll, Corinne; Winter, Kathryn; Gaffney, David K.; Ryu, Jin‐Sook; Jhingran, Anuja; Dicker, Adam P.; Weidhaas, Joanne B.; Miller, Brigitte; Magliocco, A. M.

doi:10.1016/j.ijrobp.2008.06.1180

Cited by 1 publication

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“…Therefore, Cox-2 specific inhibitors have been developed to target on malignant tissue growth and have achieved clinical benefit, although the cardiovascular side-effects associated with their use have greatly hampered their popularity (Doll et al, 2012;Ho et al, 2012;Katkoori et al, 2012). However, the definitive chemopreventive benefit derived from use of Cox-2 specific inhibitors confirms that prostaglandin pathway can serve as a valid target for chemoprevention.…”

Section: Introductionmentioning

confidence: 99%

Expression of PGDH Correlates with Cell Growth in Both Esophageal Squamous Cell Carcinoma and Adenocarcinoma

Yang

Wang²,

Xu³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Esophageal cancer represents the fourth most common gastrointestinal cancer and generally confers a poor prognosis. Prostaglandin-producing cyclo-oxygenase has been implicated in the pathogenesis of esophageal cancer growth. Here we report that prostaglandin dehydrogenase, the major enzyme responsible for prostaglandin degradation, is significantly reduced in expression in esophageal cancer in comparison to normal esophageal tissue. Reconstitution of PGDH expression in esophageal cancer cells suppresses cancer cell growth, at least in part through preventing cell proliferation and promoting cell apoptosis. The tumor suppressive role of PGDH applies equally to both squamous cell carcinoma and adenocarcinoma, which enriches our understanding of the pathogenesis of esophageal cancer and may provide an important therapeutic target.

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Section: Introductionmentioning

confidence: 99%