“…29 Furthermore, with regard to the precise prognostic value of TOP2A expression, the existing evidence base is mixed with numerous conflicting results. 7,25,29,34,37,38 Qiao et al 25 reported a subgroup analysis, which demonstrated no significant differences in overall survival or DFS between TOP2A-positive and TOP2A-negative groups in patients with breast cancer. However, Brase et al 34 reported that TOP2A expression was significantly associated with the metastasis-free interval and complete remission in patients with breast cancer.…”