ErbB1 and ErbB3 co-over expression as a prognostic factor in gastric cancer

Moghbeli, Meysam; Makhdoumi, Yasha; Delgosha, M. Soltani; Aarabi, Azadeh; Dadkhah, Ezzat; Memar, Bahram; Abdollahi, Abbas; Abbaszadegan, Mohammad Reza

doi:10.1186/s40659-018-0208-1

Cited by 32 publications

(22 citation statements)

References 48 publications

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“…There are about ninety TKs in human genome which are involved in various cellular processes such as differentiation, metabolism, motility, and proliferation [17,18]. Receptor tyrosine-kinases are up regulated in various tumors and are considered to be potential oncogenes involved in cancer initiation and development [19,20]. Therefore, targeting these oncogenes and inhibiting their expression may result in good clinical outcomes [21].…”

Section: Introductionmentioning

confidence: 99%

Role of tyrosine kinases in bladder cancer progression: an overview

Zangouei¹,

Barjasteh²,

Rahimi³

et al. 2020

Cell Commun Signal

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Background: Bladder cancer (BCa) is a frequent urothelial malignancy with a high ratio of morbidity and mortality. Various genetic and environmental factors are involved in BCa progression. Since, majority of BCa cases are diagnosed after macroscopic clinical symptoms, it is required to find efficient markers for the early detection. Receptor tyrosine-kinases (RTKs) and non-receptor tyrosine-kinases (nRTKs) have pivotal roles in various cellular processes such as growth, migration, differentiation, and metabolism through different signaling pathways. Tyrosine-kinase deregulations are observed during tumor progressions via mutations, amplification, and chromosomal abnormalities which introduces these factors as important candidates of anti-cancer therapies. Main body: For the first time in present review we have summarized all of the reported tyrosine-kinases which have been significantly associated with the clinicopathological features of BCa patients. Conclusions: This review highlights the importance of tyrosine-kinases as critical markers in early detection and therapeutic purposes among BCa patients and clarifies the molecular biology of tyrosine-kinases during BCa progression and metastasis.

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Section: Introductionmentioning

confidence: 99%

Role of tyrosine kinases in bladder cancer progression: an overview

Zangouei¹,

Barjasteh²,

Rahimi³

et al. 2020

Cell Commun Signal

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“…Finally, the mechanism about how the HER2-mTOR signal pathway-mediated autophagy regulates the tumorigenicity of GCSCs will be investigated in the following researches. In this manuscript, although others have demonstrated that co-overexpression of ErbB1 and ErbB3 can be used as a prognostic factor in GC ( 33 ), we did not examine the correlation among the expression of ErbB1 and ErbB3 of gastric stem cells because some published studies have demonstrated that adding the agents targeting the ErbB1 or ErbB3 to chemotherapy does not improve overall survival or disease control rate compared with chemotherapy alone in clinical practice ( 34 , 35 ), while Trastuzumab targeting the HER2 in combination with chemotherapy could improve the overall survival of patients with advanced GC ( 4 ). Therefore, we focused on investigating the role of HER2 in self-renewal, invasion, and tumorigenicity of GCSCs.…”

Section: Discussionmentioning

confidence: 89%

The Role of HER2 in Self-Renewal, Invasion, and Tumorigenicity of Gastric Cancer Stem Cells

et al. 2020

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Background Deregulation of HER2 expression could affect the biological characteristics of gastric cancer cells and treatment option for gastric cancer patients. This research aims to investigate the impact of HER2 on biological characteristics of gastric cancer stem cells (GCSCs) and prognosis of gastric cancer patients. Methods HER2 knockdown in GCSCs were constructed by lentivirus transfection. Alterations of proliferation, self-renewal, invasion, migration, colony formation, and tumorigenicity of GCSCs were examined. The changes of gene expressions after HER2 interference in GCSCs were detected by gene microarray. The impact of concentration of serum HER2 and expression of HER2 in tumor tissues on survival of 213 gastric cancer patients was also analyzed. Results Down-regulation of HER2 decreased the self-renewal, colony formation, migration, invasion, proliferation, and chemotherapy resistance of GCSCs. However, the tumorigenicity of GCSCs in vivo was increased after down-regulation of HER2. The results of gene microarray showed that HER2 gene might regulate the signal transduction of mTOR, Jak-STAT, and other signal pathways and affect the biological characteristics of GCSCs. Furthermore, survival analyses indicated that patients with high concentration of HER2 in serum had a favorable overall survival. However, there was no significant correlation between expression of HER2 in tumor tissue and overall survival. Conclusion Interference of HER2 in GCSCs decreased the capacity of self-renewal, proliferation, colony formation, chemotherapy resistance, invasion, and migration but might increase the tumorigenicity in vivo . Patients with high concentration of HER2 in serum seemed to have a favorable prognosis.

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“…Molecular typing of GC also has an important role in the prognosis of patients ( 35 ). In recent years, an increasing number of studies have reported that certain factors, including high co-overexpression of epidermal growth factor receptor and receptor tyrosine kinase 3, low levels of microRNA-214 and high methylation of RASSF10, are associated with poor prognosis in patients with GC ( 30 , 36 , 37 ). In the present study, the peripheral NK cell levels were determined to be an independent prognostic factor in patients with GC and patients who died within 5 years had a higher level of peripheral NK cells.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and prognostic value of the peripheral natural killer cell levels in gastric cancer

et al. 2020

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Peripheral blood lymphocyte subsets have been reported to be useful as prognostic and/or diagnostic markers for patients with cancer. However, the clinical value of peripheral blood lymphocyte subsets in gastric cancer (GC) has remained elusive. In the present study, peripheral CD3 + , CD4 + and CD8 + T lymphocytes, B cells (CD19 + ), regulatory T cells (Tregs; CD4 + CD25 + CD127 - ) and natural killer (NK) cells (CD3 - CDl6 + CD56 + ) were detected by flow cytometry in 122 patients with GC, 80 healthy donors (HDs) and 80 patients with gastric ulcer (GU). NK cells (CD56 + ) were detected by immunohistochemical (IHC) analysis in 20 GC and three GU tissue samples. A receiver-operating characteristic (ROC) curve was used to determine the threshold of the peripheral NK cell level and survival analysis was performed to assess its prognostic value in patients with GC. The results indicated that the peripheral NK cell proportion in patients with GC (18.77%) was significantly higher than that in the HD (12.19%) and GU (12.74%) groups. IHC analysis suggested that the NK level in GC tumor samples was correlated with that in paired serum samples. ROC curve analysis indicated that the peripheral NK cell level (15.16%) was able to effectively identify patients with GC, a diagnostic sensitivity of 75.41% and a specificity of 77.45% were determined. Multivariate logistic regression analysis revealed that the peripheral NK cell level was independently associated with the T stage and survival analysis demonstrated that high levels of peripheral NK cells were associated with poor prognosis of patients with GC. In conclusion, the peripheral NK cell level may be a diagnostic and prognostic marker for patients with GC.

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ErbB1 and ErbB3 co-over expression as a prognostic factor in gastric cancer

Cited by 32 publications

References 48 publications

Role of tyrosine kinases in bladder cancer progression: an overview

Role of tyrosine kinases in bladder cancer progression: an overview

The Role of HER2 in Self-Renewal, Invasion, and Tumorigenicity of Gastric Cancer Stem Cells

Diagnostic and prognostic value of the peripheral natural killer cell levels in gastric cancer

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