Eradication Treatment of Helicobacter pylori Infection: Its Importance and Possible Relationship in Preventing the Development of Gastric Cancer

Abstract

<jats:p><jats:italic>Helicobacter pylori</jats:italic>is the most important carcinogen for gastric adenocarcinoma. Bacterial virulence factors are essential players in modulating the immune response involved in the initiation of carcinogenesis in the stomach; host genetic factors contribute to the regulation of the inflammatory response and to the aggravation of mucosal damage. In terms of environmental factors, salt intake and smoking contribute to the development of lesions. Various therapeutic schemes are proposed to eradicate<jats:italic>H. pylori</jats:italic>infection, which could potentially prevent gastric cancer, offering the greatest benefit if performed before premalignant changes of the gastric mucosa have occurred.</jats:p>

Gastric cancer review

“…[ 48 ] A separate review of the eradiation trials concluded that there is a point of no return with respect to the development of H. pylori associated gastric cancer after which time treatment is ineffective at reducing the risk of malignancy. [ 49 ] Until date, the true impact of eradication of the bacteria is unknown.…”

Comparing the efficacy of four different protocols for eradicating of helicobacter pylori infection in Ahvaz, southwest Iran

“…Helicobacter pylori ( H. pylori ) was introduced to scientific society in the 1980s by Marshal and Warren, when they announced that the bacterium can be a cause for active chronic gastritis and peptic ulcer disease [ 1 ]. Since that time research was started on the subject and to date it has shown that the microorganism can cause several diseases involving the gastrointestinal tract, including acute and chronic gastritis, atrophic gastritis, peptic ulcer disease, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric adenocarcinoma [ 2 ]. Among extraintestinal diseases, the bacillus has been correlated t\ura [ 3 ], unexplained iron-deficiency anaemia [ 4 , 5 ], and idiopathic thrombocytopenic purpura (ITP) [ 6 ], and its eradication has been recommended in these cases.…”

Genomics and epidemiology for gastric adenocarcinomas

“…The recognition that Hp can cause GAC led WHO to consider Hp as a carcinogenic agent [24] and to promote its eradication as one of the strategies to prevent the disease, even after tumor resection [25,26].…”