Eradication of <i>Helicobacter pylori</i> and Resolution of Gastritis in the Gastric Mucosa of IL‐10‐Deficient Mice

Matsumoto, Yuko; Blanchard, Thomas G.; Drakes, Maureen L.; Basu, Mausumi; Redline, Raymond W.; Levine, Alan D.; Czinn, Steven J.

doi:10.1111/j.1523-5378.2005.00349.x

Cited by 43 publications

(37 citation statements)

References 43 publications

(58 reference statements)

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“…In fact, the most recent evidence suggests that in humans, the primary response to infection is actually immunoregulatory (18)(19)(20)(21)(22). This finding supports many years of animal research indicating that suppression of regulatory responses is necessary for induction of severe disease (11,(23)(24)(25)(26)(27)(28)(29)(30)(31). C57BL/6 mice, for example, develop only mild, slowly developing gastritis, while loss of immunoregulation due to absence of IL-10 (11, 31), suppression of regulatory T cells (Treg) (29,30), or adoptive transfer of effector T helper cells (23) into immunodeficient mice results in rapidly progressive severe gastritis, leading to epithelial erosions and preneoplastic changes.…”

supporting

confidence: 70%

Complex T Cell Interactions Contribute to Helicobacter pylori Gastritis in Mice

et al. 2013

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Disease due to the gastric pathogen Helicobacter pylori varies in severity from asymptomatic to peptic ulcer disease and cancer. Accumulating evidence suggests that one source of this variation is an abnormal host response. The goal of this study was to use a mouse model of H. pylori gastritis to investigate the roles of regulatory T cells (Treg) as well as proinflammatory T cells (Th1 and Th17) in gastritis, gastric T cell engraftment, and gastric cytokine production. Our results support published data indicating that severe gastritis in T cell recipient mice is due to failure of Treg engraftment, that Treg ameliorate gastritis, and that the proinflammatory response is attributable to interactions between several cell subsets and cytokines. We confirmed that gamma interferon (IFN-␥) is essential for induction of gastritis but showed that IFN-␥-producing CD4 T cells are not necessary. Interleukin 17A (IL-17A) also contributed to gastritis, but to a lesser extent than IFN-␥. Tumor necrosis factor alpha (TNF-␣) and IL-17F were also elevated in association with disease. These results indicate that while H. pylori-specific CD4 ؉ T cells and IFN-␥ are both essential for induction of gastritis due to H. pylori, IFN-␥ production by T cells is not essential. It is likely that other proinflammatory cytokines, such as IL-17F and TNF-␣, shown to be elevated in this model, also contribute to the induction of disease. We suggest that gastritis due to H. pylori is associated with loss of immunoregulation and alteration of several cytokines and cell subsets and cannot be attributed to a single immune pathway.

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supporting

confidence: 70%

Complex T Cell Interactions Contribute to Helicobacter pylori Gastritis in Mice

et al. 2013

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“…While in vivo analysis indicates that there is IFN-␥ production in the site of infection, this production is not limited to T cells, since natural killer cells have been shown to produce IFN-␥ in response to H. pylori (20). In addition, in vivo evidence suggests that, while a Th1 response has been detected (50,52) in H. pylori-infected individuals, this response is probably suboptimal (39,44).…”

Section: Discussionmentioning

confidence: 96%

“…While the predominant T-helper response in natural human infections with H. pylori is of a Th1 type, there is evidence that the strength of the Th1 response may be suboptimal. This might be a response to impaired activation of T cells by DCs (39,44).…”

mentioning

confidence: 99%

Chronic Exposure toHelicobacter pyloriImpairs Dendritic Cell Function and Inhibits Th1 Development

et al. 2007

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“…For example, Matsumoto, et al showed that IL-10-deficient mice are able to clear Helicobacter pylori infection more quickly than C57BL/6J mice (9). It is possible that this was due to a functional Slc11a1 gene rather than a lack of IL-10.…”

Section: Discussionmentioning

confidence: 99%