Eradication of Helicobacter pylori for non-ulcer dyspepsia

Martin, Paul; Soo, Shelly; Deeks, Jonathan J; Delaney, Brendan; Harris, Adam; Innes, Michael; Oakes, Rachel; Wilson, Sue; Roalfe, Andrea; Bennett, Cathy; Forman, David

doi:10.1002/14651858.cd002096.pub4

Cited by 108 publications

(68 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A controversy about the controversial role of H. pylori in functional disease has been described in some meta-analyses, which have suggested some benefit of H. pylori eradication [22]. Our study detected H. pylori infection in 30% (36/120) of the evaluated dyspeptic patients.…”

Section: Discussionsupporting

confidence: 45%

Molecular Identification of Giardia intestinalis in Patients with Dyspepsia

Fouad¹,

Esmat²,

Basyoni

et al. 2014

Digestion

View full text Add to dashboard Cite

Background/Aims:Giardia intestinalis triggers symptoms of functional dyspepsia. The aim of this study was to distinguish genotypes of G. intestinalis isolated from dyspeptic patients to evaluate their correlation with dyspeptic symptoms. Methods: In total, 120 dyspeptic subjects were investigated by upper endoscopy, including gastric and duodenal biopsies for histopathological examination, and parasitological examination of their stools and duodenal aspirates was performed. The patients were classified into five groups: group I (G. intestinalis) included 19 patients, group II (Helicobacter pylori) included 36 patients, group III (coeliac disease) included 3 patients, group IV (mixed G. intestinalis and H. pylori infection) included 4 patients, and group V (unexplained aetiology) included 58 patients. Genotyping of G. intestinalis was performed for groups I and IV using PCR-RFLP. The urease test was performed for H. pylori. Serum anti-gliadin, anti-endomysial and anti-transglutaminase antibody estimation was performed for the diagnosis of coeliac disease. Results: Genotype A of G. intestinalis was detected in the stool samples of 68.42% (13/19) and the duodenal aspirates of 42.1% (8/19) of dyspeptic patients harbouring the parasite. Genotype B was detected in 31.58% (6/19) of cases in stool samples and in 3 cases in duodenal aspirates. Conclusions:H. pylori, G. intestinalis and coeliac disease are common causes of dyspepsia. G. intestinalis genotype A demonstrated a greater association with dyspeptic symptoms.

show abstract

Section: Discussionsupporting

confidence: 45%

Molecular Identification of Giardia intestinalis in Patients with Dyspepsia

Fouad¹,

Esmat²,

Basyoni

et al. 2014

Digestion

View full text Add to dashboard Cite

show abstract

“…In view of the chronic nature of FD and its well documented adverse effects on HRQoL and work productivity [7,19,20], the patient-reported outcomes and their assessment of disease impact during long-term management are of considerable interest. The results presented here demonstrate that patients who elected to participate in the extension trial and to receive tegaserod reported improvements in HRQoL reflected by SF-NDI scores at each time point over the 1-year studies.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Tegaserod Treatment for Dysmotility-like Functional Dyspepsia: Results of Two Identical 1-year Cohort Studies

Chey

Howden

Tack³

et al. 2009

Dig Dis Sci

View full text Add to dashboard Cite

show abstract

“…There is evidence of a small but statistically significant benefit in eradicating H. pylori in H. pylori-positive dyspepsia. In a Cochrane review of 21 placebocontrolled trials, the NNT (number needed to treat) for improvement in symptoms after eradicating H. pylori was 14, with no heterogeneity between studies and no evidence of funnel plot asymmetry [10]. Therefore, the eradication therapy is recommended as first-line therapy for H. pylori-positive dyspepsia.…”

Section: Epidemiologymentioning

confidence: 99%

Symptom Generation

Matsuzaki¹,

Suzuki²

2016

Helicobacter Pylori

View full text Add to dashboard Cite

Patients whose dyspepsia symptoms had disappeared after 12 months from Helicobacter pylori (H. pylori) eradication therapy were decided to be called H. pylori-associated dyspepsia (HpD), and were clearly distinguished from functional dyspepsia. H. pylori eradication is more effective than placebo with a number needed to treat (NNT) of 14 for H. pylori-positive dyspepsia. H. pylori is likely to be associated with the presence of postprandial distress symptoms rather than epigastric pain symptoms, although the evidence whether therapeutic responses to H. pylori eradication differ between subgroups of dyspepsia is still limited. The altered ghrelin secretion from the stomach, the presence or severity of microscopic duodenitis, and altered expression of muscle-specific microRNAs in the gastric smooth muscle layer would be possible mechanisms of HpD.

show abstract

Eradication of Helicobacter pylori for non-ulcer dyspepsia

Cited by 108 publications

References 67 publications

Molecular Identification of <b><i>Giardia intestinalis</i></b> in Patients with Dyspepsia

Molecular Identification of <b><i>Giardia intestinalis</i></b> in Patients with Dyspepsia

Long-Term Tegaserod Treatment for Dysmotility-like Functional Dyspepsia: Results of Two Identical 1-year Cohort Studies

Symptom Generation

Contact Info

Product

Resources

About