Eradication of  Helicobacter pylori  and risk of peptic ulcers in patients starting long-term treatment with non-steroidal anti-inflammatory drugs: a randomised trial

Chan, Francis K.L.; To, KF; Wu, Justin Che Yuen; Yung, Man Yee; Leung, Wai K.; Kwok, Timothy; Hui, Yui; Chan, Henry Lik Yuen; Chan, Cynthia; Hui, Elsie; Woo, Jean; Sung, Joseph J.Y.

doi:10.1016/s0140-6736(02)07272-0

Cited by 290 publications

(171 citation statements)

References 23 publications

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“…There is definite role for Helicobacter pylori infection in the etiopathogenesis of duodenal ulcer (Chan et al 2002). This finding could probably be due to the high prevalence of H. pylori infection in the population (Aoki et al 2004).…”

Section: Figure 1: Treatment Modalities Offeredmentioning

confidence: 99%

Association of intestinal helminths and P. falciparum infections in co-infected school children in northwest Tanzania

Mazigo

Kidenya

Ambrose

et al. 2010

Tanzania J Hlth Res

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Plasmodium falciparum malaria and intestinal helminth infections are among the most common infections in the tropics and they share the same spatial distribution. The objective of this study was to explore the association between infections with intestinal helminths and P. falciparum infection as single helminth infections or co-infections among school children. A cross-sectional study was conducted among (OR= 0.749,, P. falciparum and hookworm (OR= 0.885, In sub-Saharan Africa, the overlapping distribution of P. falciparum and helminths infections is common and resulting into high rates of co-infections (Mazigo et al., 2010). Co-infections of helminth and P. falciparum malaria may results into synergistic or antagonistic association in causing various morbidities in infected individuals (Adrienne et al., 2005). Co-infections of soil-transmitted helminths and Schistosoma mansoni are reported to increase the incidence of clinical malaria in children (Spigel et al., 2003). In Tanzania, concomitant occurrence of asymptomatic malaria and helminth infections have been reported in school children (Mazigo et al., 2010), however, reports on their association in co-infected individuals living in various epidemiological settings in Tanzania are very limited. Thus, the present study was conducted to explore the associations of P. falciparum malaria and helminths infections in co-infected school children living in endemic area of northwest Tanzania.This cross-sectional study used data collected at baseline (before treatment) from 400 school children living and studying in selected schools in Nyamatongo village in Sengerema District in Tanzania. The village is located close to Lake Victoria. The study area, design, inclusion criteria and recruitment procedures have been describe elsewhere (Mazigo et al., 2010). At recruitment, demographic characteristics (age and sex) of the children and a finger prick blood sample were obtained and in this sample, thin and thick blood smears were prepared, stained with Giemsa and examined under the microscopy (Mazigo et al., 2010). Intensity of P. falciparum was estimated as the number of P. falciparum per 200 WBC (Mazigo et al., 2010). A single stool sample collected from primary school by HDM in a labeled container

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Section: Figure 1: Treatment Modalities Offeredmentioning

confidence: 99%

Association of intestinal helminths and P. falciparum infections in co-infected school children in northwest Tanzania

Mazigo

Kidenya

Ambrose

et al. 2010

Tanzania J Hlth Res

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“…Comment: With regard to the usefulness of H. pylori eradication therapy in patients starting treatment with NSAIDs (e.g., NSAID-naive patients), Chan et al [104] reported data at 8 weeks and 6 months after eradication of H. pylori. A significant preventative effect was not observed in patients who were being treated with NSAIDs; moreover, the results indicate that PPIs are more useful.…”

Section: Cq If a Patient Receiving Nsaids Tests Positive For Hmentioning

confidence: 99%

Evidence-based clinical practice guidelines for peptic ulcer disease 2015

et al. 2016

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The Japanese Society of Gastroenterology (JSGE) revised the evidence-based clinical practice guidelines for peptic ulcer disease in 2014 and has created an English version. The revised guidelines consist of seven items: bleeding gastric and duodenal ulcers, Helicobacter pylori (H. pylori) eradication therapy, non-eradication therapy, drug-induced ulcer, non-H. pylori, non-nonsteroidal anti-inflammatory drug (NSAID) ulcer, surgical treatment, and conservative therapy for perforation and stenosis. Ninety clinical questions (CQs) were developed, and a literature search was performed for the CQs using the Medline, Cochrane, and Igaku Chuo Zasshi databases between 1983 and June 2012. The guideline was developed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Therapy is initially provided for ulcer complications. Perforation or stenosis is treated with surgery or conservatively. Ulcer bleeding is first treated by endoscopic hemostasis. If it fails, surgery or interventional radiology is chosen. Second, medical therapy is provided. In cases of NSAID-related ulcers, use of NSAIDs is stopped, and anti-ulcer therapy is provided. If NSAID use must continue, the ulcer is treated with a proton pump inhibitor (PPI) or prostaglandin analog. In cases with no NSAID use, H. pylori-positive patients receive eradication and anti-ulcer therapy. If first-line eradication therapy fails, second-line therapy is given. In cases of non-H. pylori, non-NSAID ulcers or H. pyloripositive patients with no indication for eradication therapy, non-eradication therapy is provided. The first choice is PPI therapy, and the second choice is histamine 2-receptor antagonist therapy. After initial therapy, maintenance therapy is provided to prevent ulcer relapse.

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“…For primary prevention of peptic ulcer and complications, H pylori eradication before starting NSAIDs significantly diminishes its occurrence as well as bleeding, despite concomitant use of proton pump inhibitors (20,201) .…”

Section: Statement 24mentioning

confidence: 99%

“…In this scenario, using a proton pump inhibitor is better than simply eradicating the bacteria (19) . The best protection for the patient in these cases is to apply both, namely, the proton pump inhibitor and eradicating H pylori (20) .…”

Section: Statement 24mentioning

confidence: 99%

3rd BRAZILIAN CONSENSUS ON Helicobacter pylori

Coelho

Maguinilk

Zaterka³

et al. 2013

Arq. Gastroenterol.

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Significant progress has been obtained since the Second Brazilian Consensus Conference on Helicobacter pylori Infection held in 2004, in São Paulo, SP, Brazil, and justify a third meeting to establish updated guidelines on the current management of H. pylori infection. The Third Brazilian Consensus Conference on H pylori Infection was organized by the Brazilian Nucleus for the Study of Helicobacter, a Department of the Brazilian Federation of Gastroenterology and took place on April 12-15, 2011, in Bento Gonçalves, RS, Brazil. Thirty-one delegates coming from the five Brazilian regions and one international guest, including gastroenterologists, pathologists, epidemiologists, and pediatricians undertook the meeting. The participants were allocated in one of the five main topics of the meeting: H pylori, functional dyspepsia and diagnosis; H pylori and gastric cancer; H pylori and other associated disorders; H pylori treatment and retreatment; and, epidemiology of H pylori infection in Brazil. The results of each subgroup were submitted to a final consensus voting to all participants. Relevant data were presented, and the quality of evidence, strength of recommendation, and level of consensus were graded. Seventy per cent and more votes were considered as acceptance for the final statement. This article presents the main recommendations and conclusions to guide Brazilian doctors involved in the management of H pylori infection.

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Eradication of Helicobacter pylori and risk of peptic ulcers in patients starting long-term treatment with non-steroidal anti-inflammatory drugs: a randomised trial

Cited by 290 publications

References 23 publications

Association of intestinal helminths and P. falciparum infections in co-infected school children in northwest Tanzania

Association of intestinal helminths and P. falciparum infections in co-infected school children in northwest Tanzania

Evidence-based clinical practice guidelines for peptic ulcer disease 2015

3rd BRAZILIAN CONSENSUS ON Helicobacter pylori

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