Eradication of carriage with methicillin-resistant Staphylococcus aureus: determinants of treatment failure

Ammerlaan, Heidi S. M.; Kluytmans, Jan; Berkhout, Hanneke; Buiting, A. G. M.; Brauwer, E.I.G.B. De; Broek, P.J. van den; Gelderen, Paula van; Leenders, Sander; Ott, Alewijn; Richter, Clemens; Spanjaard, Lodewijk; Spijkerman, Ingrid J. B.; Tiel, Frank H. van; Voorn, G. Paul; Wulf, M.W.H.; Zeijl, Jan van; Troelstra, Annet; Bonten, Marc J. M.; Berg, Ch.; Bosman, J. H.; Bremer, Andreas; Bril, W.; Commeren, D.; Essen, G. van; Gigengack-Baars, A.; Kasteren, M. M. E. van; Lommerse, E. J. M.; Mascini, Ellen M.; Renders, Nicole H. M.; Rijen, M. van; Schellekens, Jeroen J. A.; Smeets, Ed; Sprangers, T.; Vandenbroucke-Grauls, Christina M. J. E.; Verbon, Annelies; Verduin, Kees; Wagenvoort, J. H. T.; Wijngaarden, Peter van

doi:10.1093/jac/dkr250

Cited by 45 publications

(34 citation statements)

References 16 publications

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“…These failures are essentially explained by the multiplicity of colonized sites (armpits, groin, throat, etc.) [31]. Furthermore, using mupirocine creates resistant strains.…”

Section: Discussionmentioning

confidence: 99%

Staphylococcus aureus nasal carriage during the infectious diseases national congress in France

Boisseau¹,

Alfandari²,

Gauzit³

et al. 2012

Médecine et Maladies Infectieuses

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“…These failures are essentially explained by the multiplicity of colonized sites (armpits, groin, throat, etc.) [31]. Furthermore, using mupirocine creates resistant strains.…”

Section: Discussionmentioning

confidence: 99%

Staphylococcus aureus nasal carriage during the infectious diseases national congress in France

Boisseau¹,

Alfandari²,

Gauzit³

et al. 2012

Médecine et Maladies Infectieuses

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“…Successful nasal decolonization of S. aureus is difficult to achieve, and S. aureus readily recolonizes the nose, the throat and other sites within one week, commonly with the same S. aureus genotype [8–11]. Today, nasal mupirocin is the most efficacious regimen of S. aureus eradication from the anterior nares [12, 13]. However, the success rate for eradication of MRSA is low 12 months after decolonization [14].…”

Section: Introductionmentioning

confidence: 99%

Localization of Staphylococcus aureus in tissue from the nasal vestibule in healthy carriers

et al. 2017

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BackgroundColonization of the body is an important step in Staphylococcus aureus infection. S. aureus colonizes skin and mucous membranes in humans and several animal species. One important ecological niche of S. aureus is the anterior nares. More than 60% of the S. aureus in the nose are found in vestibulum nasi. Our aim was to describe the localization of S. aureus in nasal tissue from healthy carriers.MethodsPunch skin biopsies were taken from vestibulum nasi from healthy volunteers (S. aureus carriers and non−/intermittent carriers, n = 39) attending the population-based Tromsø 6 study. The tissue samples were processed as frozen sections before immunostaining with a specific S. aureus antibody, and finally evaluated by a confocal laser-scanning microscope.ResultsOur results suggest that S. aureus colonize both the upper and lower layers of the epidermis within the nasal epithelium of healthy individuals. The number of S. aureus in epidermis was surprisingly low. Intracellular localization of S. aureus in nasal tissue from healthy individuals was also detected.ConclusionsKnowledge of the exact localization of S. aureus in nasal tissue is important for the understanding of the host responses against S. aureus. Our results may have consequences for the eradication strategy of S. aureus in carriers, and further work can provide us with tools for targeted prevention of S. aureus colonisation and infection.Electronic supplementary materialThe online version of this article (doi:10.1186/s12866-017-0997-3) contains supplementary material, which is available to authorized users.

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“…Acton et al reviewed cases involving the intestinal carriage of S. aureus [10]. Ammeriaan et al reported that one of the causes of treatment failure for MRSA carriers might be due to the presence of strains colonized at extra-nasal sites [11]. Although MRSA infection is decreasing as results of infection control e.g., performing standard precaution, active surveillance culture, and cohorting, outbreak of MRSA strains still occurred.…”

Section: Introductionmentioning

confidence: 99%

Intestinal carriage of methicillin-resistant Staphylococcus aureus in nasal MRSA carriers hospitalized in the neonatal intensive care unit

Nakao

Ito

Han

et al. 2014

Antimicrob Resist Infect Control

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BackgroundThe current data regarding the correlation between the methicillin-resistant Staphylococcus aureus (MRSA) clones carried in the nasal cavity and digestive tract are inadequate.MethodsMRSA strains were isolated from both the feces and nasal swabs of 21 nasal-MRSA carriers ranging from 10 to 104 days of age treated at the neonatal intensive care units of two hospitals. The molecular epidemiological characteristics of the isolates were determined: multilocus sequence types, spa-types, staphylococcal cassette chromosome mec (SCCmec) types, carriage of four exotoxin genes, and genes contained in commercially available kit.ResultsThe feces of all nasal carriers contained MRSA at levels ranging from 4.0 × 102 to 2.8 × 108 colony forming units/g feces. The MRSA clones isolated from the feces and the nasal swabs of each patient were the same. Four MRSA clones, clonal complex (CC) 8-SCCmec IVl, CC8-SCCmec IVb, CC1-SCCmec IVa and CC5-SCCmec IIa were identified from 21 patients. All CC8-SCCmec IVl strains and one of three CC5-SCCmec IIa strains carried the toxic shock syndrome toxin gene.ConclusionsThe feces of tested MRSA carriers contained the same MRSA clones as the nasal isolates in considerable amounts, suggesting that more careful attention should be paid for the handling of excrement in the case of newborn babies or infants than that of adults.

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Eradication of carriage with methicillin-resistant Staphylococcus aureus: determinants of treatment failure

Cited by 45 publications

References 16 publications

Staphylococcus aureus nasal carriage during the infectious diseases national congress in France

Staphylococcus aureus nasal carriage during the infectious diseases national congress in France

Localization of Staphylococcus aureus in tissue from the nasal vestibule in healthy carriers

Intestinal carriage of methicillin-resistant Staphylococcus aureus in nasal MRSA carriers hospitalized in the neonatal intensive care unit

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