Eradication of a multiple drug resistant Salmonella paratyphi A causing meningitis with ciprofloxacin

Bhutta, Zulfiqar Ahmed; Farooqui, Badr J.; Sturm, Alexander

doi:10.1016/0163-4453(92)94173-u

Cited by 23 publications

(10 citation statements)

References 13 publications

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“…The quinolones demonstrate excellent activity against Salmonella and penetrate the CSF better than any other class of antibiotic [52,53]. Several case reports of Salmonella meningitis confirm a favorable response [54,55]. Prolonged therapy for Salmonella meningitis is indicated in view of the slow response noted in the literature and the frequent reported relapses.…”

Section: Discussionmentioning

confidence: 96%

Salmonella Meningitis: Report of Three Cases in Adults and Literature Review

Karim

Islam

2002

Infection

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Salmonella meningitis is an unusual complication of Salmonella sepsis and occurs almost exclusively in infants and young children. One case of Salmonella meningitis and two cases of cerebrospinal fluid (CSF) pleocytosis in adult patients with Salmonella bacteremia were studied and the literature was reviewed. On a retrospective review of the charts of 100 sequential patients with Salmonella typhi and S. paratyphi-positive blood cultures, we found one patient with fulminant Salmonella meningitis and two others with CSF pleocytosis. All three patients survived. The patient with Salmonella meningitis had significant residual neurologic sequela. Salmonella encephalopathy occurred in six other patients who presented with headache and were confused or drowsy. Cases of meningitis in adults do occur and are associated with a high morbidity and mortality. Newer cephalosporn antibiotics may be the therapy of choice in these infections.

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Section: Discussionmentioning

confidence: 96%

Salmonella Meningitis: Report of Three Cases in Adults and Literature Review

Karim

Islam

2002

Infection

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“…There has been a report of S. Paratyphi A causing meningitis in a 10-day-old breast-feeding baby in north Pakistan but the organism couldn't be isolated from the blood. 2 Other Salmonellae as S. Typhimurium, S. Anatum, S. Senftenberg, and S. Newport have already been incriminated as pathogens in neonatal sepsis.…”

Section: Discussionmentioning

confidence: 99%

Paratyphoid sepsis

et al. 2007

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A large for gestational age male baby was born to a healthy young primigravida, on L-thyroxime, at 40 weeks by caesarean delivery in a tertiary care hospital. The baby had episodes of hypoglycemia during his immediate four postnatal days in the nursery that were successfully managed with intravenous glucose administration. The baby became unwell on day 5 and had a positive sepsis-screening test. Blood culture revealed a multidrug susceptible S. Paratyphi A strain, which he probably acquired on the first or second postnatal day from the contaminated expressed breast milk or the formula feed.

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“…One case of a Pseudomonas aeruginosa meningitis that failed to respond to treatment based on cefotaxime combined with gentamicin was cured with ciprofloxacin combined with tobramycin [55]. Ciprofloxacin has also been used successfully to treat sporadic cases of neonatal meningitis due to Salmonella paratyphi, E. coli, and Flavobacterium meningosepticum [56,57]. A 68-year-old woman who developed P. aeruginosa meningitis after a laminectomy was cured by addition of high doses of ciprofloxacin (3 x 400 mg IV) to the previous regimen of ceftazidime and gentamicin.…”

Section: Clinical Trialsmentioning

confidence: 97%

Fluoroquinolones in the treatment of meningitis

Cottagnoud

Täuber²

2003

Curr Infect Dis Rep

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The continuous increase of resistant pathogens causing meningitis has limited the efficacy of standard therapeutic regimens. Due to their excellent activity in vitro and their good penetration into the cerebrospinal fluid (CSF), fluoroquinolones appear promising for the treatment of meningitis caused by gram-negative microorganisms, ie, Neisseria meningitidis and nosocomial gram-negative bacilli. The newer fluoroquinolones (moxifloxacin, gemifloxacin, gatifloxacin, and garenoxacin) have excellent activity against gram-positive microorganisms. Studies in animal models and limited clinical data indicate that they may play a future role in the treatment of pneumococcal meningitis. Analysis of pharmacodynamic parameters suggests that CSF concentrations that produce a C(peak)/minimal bactericidal concentration (MBC) ratio of at least 5 and concentrations above the MBC during the entire dosing interval are a prerequisite for maximal bactericidal activity in meningitis. Of interest, newer fluoroquinolones act synergistically with vancomycin and beta-lactam antibiotics (ceftriaxone, cefotaxime, meropenem) against penicillin-resistant pneumococci in experimental rabbit meningitis, potentially providing a new therapeutic strategy. Clinical trials are needed to further explore the usefulness of quinolones as single agents or in combination with other drugs in the therapy of pneumococcal meningitis.

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Eradication of a multiple drug resistant Salmonella paratyphi A causing meningitis with ciprofloxacin

Cited by 23 publications

References 13 publications

Salmonella Meningitis: Report of Three Cases in Adults and Literature Review

Salmonella Meningitis: Report of Three Cases in Adults and Literature Review

Paratyphoid sepsis

Fluoroquinolones in the treatment of meningitis

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