ER stress-enhanced HMGA2 plays an important role in Cr (VI)-induced glycolysis and inhibited oxidative phosphorylation by targeting the transcription of ATF4

Luo, Shengxiang; Zhang, Cong; Gao, Zeyun; Jiang, Liping; Li, Qiujuan; Shi, Xiaoxia; Kong, Ying; Cao, Jun

doi:10.1016/j.cbi.2022.110293

Cited by 5 publications

(1 citation statement)

References 43 publications

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“…Most ATP production in the adult lens is produced by glycolysis, likely due to the intrinsic hypoxia of the lens environment [95]. While genes mapping to the gene ontology terms related to "hypoxia" are not over-represented among the Atf4 null DEGs, numerous genes encoding proteins important for glycolysis are expressed at lower levels in Atf4 null lenses than littermate controls, a result consistent with prior reports that ATF4 mediates stress-induced shifts towards glycolytic metabolism in other cell types [96,97]. Notably, HIF1a, the canonical transcription factor mediating survival of hypoxic cells, is also abundant in the lens and necessary for postnatal lens survival and growth in mice [98,99] and lens fiber cell denucleation in chickens [100].…”

Section: Atf4 Likely Functions To Metabolically Adapt the Lens To Its...supporting

confidence: 86%

ATF4 May Be Essential for Adaption of the Ocular Lens to Its Avascular Environment

Xiang,

Pompetti,

Faranda

et al. 2023

Cells

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The late embryonic mouse lens requires the transcription factor ATF4 for its survival although the underlying mechanisms were unknown. Here, RNAseq analysis revealed that E16.5 Atf4 null mouse lenses downregulate the mRNA levels of lens epithelial markers as well as known markers of late lens fiber cell differentiation. However, a comparison of this list of differentially expressed genes (DEGs) with other known transcriptional regulators of lens development indicated that ATF4 expression is not directly controlled by the previously described lens gene regulatory network. Pathway analysis revealed that the Atf4 DEG list was enriched in numerous genes involved in nutrient transport, amino acid biosynthesis, and tRNA charging. These changes in gene expression likely result in the observed reductions in lens free amino acid and glutathione levels, which would result in the observed low levels of extractable lens protein, finally leading to perinatal lens disintegration. These data demonstrate that ATF4, via its function in the integrated stress response, is likely to play a crucial role in mediating the adaption of the lens to the avascularity needed to maintain lens transparency.

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Section: Atf4 Likely Functions To Metabolically Adapt the Lens To Its...supporting

confidence: 86%

ATF4 May Be Essential for Adaption of the Ocular Lens to Its Avascular Environment

Xiang,

Pompetti,

Faranda

et al. 2023

Cells

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show abstract

An Overview of Hexavalent Chromium-Induced Necroptosis, Pyroptosis, and Ferroptosis

Kurmangaliyeva,

Baktikulova,

Tkachenko

et al. 2024

Biol Trace Elem Res

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Phelligridimer A enhances the expression of mitofusin 2 and protects against cerebral ischemia/reperfusion injury

Li,

Xu,

Long

et al. 2024

Chemico-Biological Interactions

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ER stress-enhanced HMGA2 plays an important role in Cr (VI)-induced glycolysis and inhibited oxidative phosphorylation by targeting the transcription of ATF4

Cited by 5 publications

References 43 publications

ATF4 May Be Essential for Adaption of the Ocular Lens to Its Avascular Environment

ATF4 May Be Essential for Adaption of the Ocular Lens to Its Avascular Environment

An Overview of Hexavalent Chromium-Induced Necroptosis, Pyroptosis, and Ferroptosis

Phelligridimer A enhances the expression of mitofusin 2 and protects against cerebral ischemia/reperfusion injury

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