2015
DOI: 10.1083/jcb.201502105
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ER–mitochondrial junctions can be bypassed by dominant mutations in the endosomal protein Vps13

Abstract: Substitutions in Vps13 suppress all measured phenotypic consequences of ERMES deficiency, and Vps13 dynamically localizes to vacuole–mitochondria and to vacuole–nucleus contact sites depending on growth conditions, suggesting that ERMES function can be bypassed by the activity of other contact sites, and that contact sites establish a growth condition–regulated organelle network.

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Cited by 209 publications
(311 citation statements)
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“…It is known that vCLAMP formation is repressed under the respiring condition, and in support of the idea that Vps13 integrates vCLAMP, Vps13 relocalized to NVJs upon switching cells from a fermentable to nonfermentable carbon source, whereas dominant variants of Vps13 did not relocalize to NVJ contact sites. Importantly, genetic interaction analyses suggest that Vps13, Vps39, and Mcp1 function in the same pathway, whereas Mcp2 does not (109). Consistent with the dynamic nature of ERMES and vCLAMP, it was observed that these two complexes were reversibly lost under nutrient stress.…”
Section: Multiple Roles For Ermes In Mitochondrial Biologysupporting
confidence: 58%
See 1 more Smart Citation
“…It is known that vCLAMP formation is repressed under the respiring condition, and in support of the idea that Vps13 integrates vCLAMP, Vps13 relocalized to NVJs upon switching cells from a fermentable to nonfermentable carbon source, whereas dominant variants of Vps13 did not relocalize to NVJ contact sites. Importantly, genetic interaction analyses suggest that Vps13, Vps39, and Mcp1 function in the same pathway, whereas Mcp2 does not (109). Consistent with the dynamic nature of ERMES and vCLAMP, it was observed that these two complexes were reversibly lost under nutrient stress.…”
Section: Multiple Roles For Ermes In Mitochondrial Biologysupporting
confidence: 58%
“…ERMES mutants acquire suppressors easily (86,109), and the characterization of suppressed mmm1 mutant strains able to grow on a nonfermentable carbon source led to the identification of two dominant mutations in Vps13 as causative of the suppressed phenotype (109). cells into a normal tubular shape.…”
Section: Multiple Roles For Ermes In Mitochondrial Biologymentioning
confidence: 99%
“…Mutations affecting ER contacts with various organelles can result in severe neurological diseases, including amyotrophic lateral sclerosis (93), Huntington's-like chorea (80), and neuroacanthocytosis (64,94). Abnormal functions of MCSs have also been proposed to have a role in Alzheimer's disease (95).…”
Section: Discussionmentioning
confidence: 99%
“…It was recently shown that overexpression of Lam6, a sterol binding protein [15] and a ERMES contact site resident [14] results in an extension of both contacts [13]. Vps13, which also localizes to both ERMES and vCLAMP might also play a role in the coordination between the two [17]. These studies support the notion that the ERmitochondria and mitochondria-vacuole contacts can work in a redundant fashion.…”
Section: Machinery and Functionmentioning
confidence: 62%