ER-60 (PDIA3) is highly expressed in a newly established serous ovarian cancer cell line, YDOV-139

Chay, Doo Byung; Cho, Hanbyoul; Lim, Beom Jin; Kang, Eun Suk; Oh, Yoon Jin; Choi, Sun Mi; Kim, Bo Wook; Kim, Young Tae; Kim, Jae Hoon

doi:10.3892/ijo_00000688

Cited by 19 publications

(2 citation statements)

References 37 publications

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“…OATP1B3 has also been observed in endometrial carcinoma, where high levels significantly correlated with type I tumors and longer disease-free survival (Ogane et al, 2013) (Table 3). High levels of OATP1B3 and lower levels of OATP1B1 have also been reported in ovarian cancer samples (Arakawa et al, 2012; Furihata et al, 2015; Thakkar et al, 2015) and cancer cell lines (Cho et al, 2009; Chay et al, 2010; Svoboda et al, 2011; Lancaster et al, 2013) (Table 3). In addition to OATP1B3 and OATP1B1, also OATP2B1, OATP3A1, and OATP4A1 have been detected at the mRNA level in ovarian cancer samples (Tamai et al, 2000).…”

Section: Disturbed Transport and Estrogen Actions In Gynecological Camentioning

confidence: 81%

The Importance of Steroid Uptake and Intracrine Action in Endometrial and Ovarian Cancers

2017

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Endometrial and ovarian cancers predominately affect women after menopause, and are more frequently observed in developed countries. These are considered to be hormone-dependent cancers, as steroid hormones, and estrogens in particular, have roles in their onset and progression. After the production of estrogens in the ovary has ceased, estrogen synthesis occurs in peripheral tissues. This depends on the cellular uptake of estrone-sulfate and dehydroepiandrosterone-sulfate, as the most important steroid precursors in the plasma of postmenopausal women. The uptake through transporter proteins, such as those of the organic anion-transporting polypeptide (OATP) and organic anion-transporter (OAT) families, is followed by the synthesis and action of estradiol E2. Here, we provide an overview of the current understanding of this intracrine action of steroid hormones, which depends on the availability of the steroid precursors and transmembrane transporters for precursor uptake, along with the enzymes for the synthesis of E2. The data is also provided relating to the selected transmembrane transporters from the OATP, OAT, SLC51, and ABC-transporter families, and the enzymes involved in the E2-generating pathways in cancers of the endometrium and ovary. Finally, we discuss these transporters and enzymes as potential drug targets.Keywords: sulfatase, aromatase, 17beta-hydroxysteroid dehydrogenase, transporters, OATP, ABC-transporter HORMONE-DEPENDENT CANCERSSteroid hormones have important roles in human physiology, and the disruption of androgen, estrogen, and progesterone actions are implicated in the development of hormone-dependent cancers and benign hormone-dependent diseases. Hormone-dependent cancers include prostate, breast, endometrial, and ovarian cancers, which comprise more than 20% of all cancers in humans, and more than 35% of cancers in women (Ferlay et al., 2013). Indeed, in women, breast cancer is the most frequent cancer in the developed world. In 2012, 1,671,149 new cases of breast cancer were estimated worldwide, with 521,907 associated deaths. In the developed world, endometrial cancer is the most common among gynecological cancers. Worldwide, there were 319,605 new cases and 76,160 deaths from endometrial cancer in 2012 alone (Ferlay et al., 2013). The most deadly of the hormone-dependent cancers is ovarian cancer. Worldwide, there were 238,719 new cases and 151,905 deaths from ovarian cancer in 2012 (Ferlay et al., 2013).

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Section: Disturbed Transport and Estrogen Actions In Gynecological Camentioning

confidence: 81%

The Importance of Steroid Uptake and Intracrine Action in Endometrial and Ovarian Cancers

2017

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“…A recent study demonstrated that SLCO4A1 was highly expressed in several other cancers including colorectal cancer, and it served as a prognostic marker for colorectal cancer [ 9 ]. In addition, the expression of SLCO4A1 is strongly increased in ovarian cancers [ 16 ]. Interestingly, organic anion transporting polypeptides, uptake transporters of the solute carrier family, are found to be elevated in diverse cancers, such as colorectal cancer and pancreatic cancer [ 17 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

LncRNA SLCO4A1-AS1 modulates colon cancer stem cell properties by binding to miR-150-3p and positively regulating SLCO4A1

Song

et al. 2021

Laboratory Investigation

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Long non-coding RNAs (lncRNAs) play important roles in a range of different human cancers. However, the role of lncRNA solute carrier organic anion transporter family member 4A1-AS1 (SLCO4A1-AS1) in colon cancer remains enigmatic. Hence, we aimed to explore the specific role of SLCO4A1-AS1 in colon cancer stem cells. Colon cancer-related differentially expressed lncRNA and mRNA were screened using microarray-based analysis, and the expression of SLCO4A1-AS1 and SLCO4A1 in colon cancer tissues was determined using reverse transcription quantitative polymerase chain reaction and western blot analysis. The interaction among SLCO4A1-AS1, microRNA-150-3p (miR-150-3p) and SLCO4A1 was verified using dual-luciferase reporter assay, RNA immunoprecipitation and RNA pull-down. Moreover, SLCO4A1-AS1, miR-150-3p and/or SLCO4A1 were overexpressed or depleted in colon cancer cells to detect their effects on migration, invasion, sphere formation, apoptosis and tumorigenesis abilities of colon cancer stem CD133+CD44+ cells using both in vitro and in vivo assays. SLCO4A1-AS1 and SLCO4A1 were screened as the differentially expressed lncRNA and mRNA in colon cancer tissues. SLCO4A1-AS1 was confirmed to competitively bind to miR-150-3p to elevate SLCO4A1 expression. Moreover, knockdown of SLCO4A1-AS1 decreased SLCO4A1 expression, thus inhibiting cell migration, invasion, sphere formation, and tumorigenesis abilities and enhancing the apoptosis of CD133+CD44+ cells. Collectively, these findings provide evidence demonstrating that depleting SLCO4A1-AS1 competitively binds to miR-150-3p, which downregulates SLCO4A1 expression, thus hindering colon cancer progression.

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Differential network analysis reveals the genome-wide landscape of estrogen receptor modulation in hormonal cancers

Hsiao¹,

Chiu

Hsu

et al. 2016

Sci Rep

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Several mutual information (MI)-based algorithms have been developed to identify dynamic gene-gene and function-function interactions governed by key modulators (genes, proteins, etc.). Due to intensive computation, however, these methods rely heavily on prior knowledge and are limited in genome-wide analysis. We present the modulated gene/gene set interaction (MAGIC) analysis to systematically identify genome-wide modulation of interaction networks. Based on a novel statistical test employing conjugate Fisher transformations of correlation coefficients, MAGIC features fast computation and adaption to variations of clinical cohorts. In simulated datasets MAGIC achieved greatly improved computation efficiency and overall superior performance than the MI-based method. We applied MAGIC to construct the estrogen receptor (ER) modulated gene and gene set (representing biological function) interaction networks in breast cancer. Several novel interaction hubs and functional interactions were discovered. ER+ dependent interaction between TGFβ and NFκB was further shown to be associated with patient survival. The findings were verified in independent datasets. Using MAGIC, we also assessed the essential roles of ER modulation in another hormonal cancer, ovarian cancer. Overall, MAGIC is a systematic framework for comprehensively identifying and constructing the modulated interaction networks in a whole-genome landscape. MATLAB implementation of MAGIC is available for academic uses at https://github.com/chiuyc/MAGIC.

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ER-60 (PDIA3) is highly expressed in a newly established serous ovarian cancer cell line, YDOV-139

Cited by 19 publications

References 37 publications

The Importance of Steroid Uptake and Intracrine Action in Endometrial and Ovarian Cancers

The Importance of Steroid Uptake and Intracrine Action in Endometrial and Ovarian Cancers

LncRNA SLCO4A1-AS1 modulates colon cancer stem cell properties by binding to miR-150-3p and positively regulating SLCO4A1

Differential network analysis reveals the genome-wide landscape of estrogen receptor modulation in hormonal cancers

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