2014
DOI: 10.1007/s00259-014-2917-1
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Equivocal usefulness of FDG for the noninvasive imaging of abdominal aortic aneurysms

Abstract: Abdominal aortic aneurysms (AAA) usually progress asymptomatically and are undetected until rupture occurs. Once ruptured, the mortality rate of AAA is about 80 %. Among all patients with ruptured AAA, about one-third die without reaching hospital, and about another quarter reach hospital but die prior to surgical intervention. Among the remaining patients (about 40 %) surviving AAA rupture long enough to benefit from surgical intervention, the perioperative mortality has historically reached about 50 % [1], a… Show more

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Cited by 3 publications
(1 citation statement)
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“…Therefore, FDG uptake would not necessarily be associated with a deleterious outcome, depending on the cells or cell subtypes present in the aneurysm. For example, there are two antagonist subtypes of macrophages within vascular lesions that could not be distinguished by FDG PET: one pro-atherogenic and pro-inflammatory type, called M1, and the opposite, called M2 [ 98 ]. It nevertheless makes sense that FGD uptake tracks inflammation, but the counterhypothesis that inflammatory activity in the aortic wall would be the consequence of expansion rather than the cause has never been tested.…”
Section: Resultsmentioning
confidence: 99%
“…Therefore, FDG uptake would not necessarily be associated with a deleterious outcome, depending on the cells or cell subtypes present in the aneurysm. For example, there are two antagonist subtypes of macrophages within vascular lesions that could not be distinguished by FDG PET: one pro-atherogenic and pro-inflammatory type, called M1, and the opposite, called M2 [ 98 ]. It nevertheless makes sense that FGD uptake tracks inflammation, but the counterhypothesis that inflammatory activity in the aortic wall would be the consequence of expansion rather than the cause has never been tested.…”
Section: Resultsmentioning
confidence: 99%