Equivalent circuit model of a non-faradaic impedimetric ZnO nano-crystal biosensor

Eveness, John; Cao, Lu; Kiely, Janice; Luxton, Richard

doi:10.1016/j.jelechem.2021.116003

Cited by 18 publications

(9 citation statements)

References 34 publications

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“…This increase in capacitance can be attributed to the increased charge carrier density and alterations in dielectric permittivity at the electrode/electrolyte interfacial capacitance. 8,10 The interfacial capacitance is sensitive to changes in charge carrier density, permittivity, surface roughness and double layer thickness.…”

Section: Resultsmentioning

confidence: 99%

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Effect of Applied AC Voltage on the Performance of Non-Faradaic Impedimetric Biosensors

Alzahrani,

Almansour,

Qurayshan

et al. 2024

J. Electrochem. Soc.

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Electrochemical impedance spectroscopy based non-faradaic biosensors are promising low-cost and rapid detection tools for a variety of biomarkers. Unlike faradaic impedimetric biosensors, non-faradaic impedimetric biosensors are redox-free and do not require the use of three electrodes. Instead, two electrodes are enough to carry out biosensing. Commonly used AC perturbation during non-faradaic impedimetric biosensors is 10 mV to maintain the linearity of the electrochemical biosensor. In this work, we investigated the effect of different AC voltages (10, 50, 100, 200, 400, 800, and 1600 mV) on bare gold interdigitated electrodes (Au-IDEs). As the AC voltage increased, the capacitance and phase of bare Au-IDEs increased whereas the impedance decreased. At 800 and 1600 mV, non-linear effects started to appear on the Lissajous plots. Then, the effect of all the AC voltages except 800 and 1600 mV on the performance of fully functionalized non-faradaic LDL-cholesterol sensors were investigated. Increasing the AC voltage resulted in better limit of detection and change in capacitance. However, it also resulted in larger change in capacitance due to testing against negative (control samples). The reported study can be useful for the future development of non-faradaic impedimetric biosensors for the detection of different biomarkers.

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Section: Resultsmentioning

confidence: 99%

“…7 The interfacial capacitive change in non-faradaic EIS-based biosensors arises from changes in charge, area, material thickness or dielectric properties at the biosensor surface. [8][9][10] Therefore, given the advantages of non-faradaic EIS over faradaic EIS, the first one is more promising for the direct and label-free detection of diseases.…”

mentioning

confidence: 99%

Effect of Applied AC Voltage on the Performance of Non-Faradaic Impedimetric Biosensors

Alzahrani,

Almansour,

Qurayshan

et al. 2024

J. Electrochem. Soc.

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“…The biosensor included a PET insulating layer between the electrodes and the active ZnO sensor surface. 19 In phosphate-buffered saline (PBS) solution, an In 2 O 3 electrically modulated FET biosensing device with great durability was developed and can be employed as a biosensor to respond to miR-21. 20 2.3.…”

Section: Different Types Of Biosensors Formentioning

confidence: 99%

“…Eveness et al developed an electric biosensor based on a polyethylene terephthalate-ZnO co-planar electrode to quantify variable amounts of C-reactive protein (CRP). The biosensor included a PET insulating layer between the electrodes and the active ZnO sensor surface . In phosphate-buffered saline (PBS) solution, an In 2 O 3 electrically modulated FET biosensing device with great durability was developed and can be employed as a biosensor to respond to miR-21 …”

Section: Different Types Of Biosensors For Detectionmentioning

confidence: 99%

Prospects of Biosensors Based on Functionalized and Nanostructured Solitary Materials: Detection of Viral Infections and Other Risks

et al. 2022

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Advances in nanotechnology over the past decade have emerged as a substitute for conventional therapies and have facilitated the development of economically viable biosensors. Next-generation biosensors can play a significant role in curbing the spread of various viruses, including HCoV-2, and controlling morbidity and mortality. Pertaining to the impact of the current pandemic, there is a need for point-of-care biosensor-based testing as a detection method to accelerate the detection process. Integrating biosensors with nanostructures could be a substitute for ultrasensitive label-free biosensors to amplify sensing and miniaturization. Notably, next-generation biosensors could expedite the detection process. An elaborate description of various types of functionalized nanomaterials and their synthetic aspects is presented. The utility of the functionalized nanostructured materials for fabricating nanobiosensors to detect several types of viral infections is described in this review. This review also discusses the choice of appropriate nanomaterials, as well as challenges and opportunities in the field of nanobiosensors.

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“…The electrical biosensor [ 1 ] for electrical triggers in drug delivery systems (DDS) [ 2 ] has become popular because of the advancement of nanotechnology [ 3 , 4 ], making the nanochip smaller than the minimum red blood cell size of 1.7 µm [ 5 ]. This nanochip [ 6 , 7 , 8 ] is used as a drug reservoir, carrier, and release to control the drug load and delivery [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

CuZn Complex Used in Electrical Biosensors for Drug Delivery Systems

Miskon

Zaidi

2022

Materials

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This paper is to discuss the potential of using CuZn in an electrical biosensor drug carrier for drug delivery systems. CuZn is the main semiconductor ingredient that has great promise as an electrochemical detector to trigger releases of active pharmaceutical ingredients (API). This CuZn biosensor is produced with a green metal of frameworks, which is an anion node in conductive polymers linked by bioactive ligands using metal–polymerisation technology. The studies of Cu, Zn, and their oxides are highlighted by their electrochemical performance as electrical biosensors to electrically trigger API. The three main problems, which are glucose oxidisation, binding affinity, and toxicity, are highlighted, and their solutions are given. Moreover, their biocompatibilities, therapeutic efficacies, and drug delivery efficiencies are discussed with details given. Our three previous investigations of CuZn found results similar to those of other authors’ in terms of multiphases, polymerisation, and structure. This affirms that our research is on the right track, especially that related to green synthesis using plant extract, CuZn as a nanochip electric biosensor, and bioactive ligands to bind API, which are limited to the innermost circle of the non-enzymatic glucose sensor category.

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Equivalent circuit model of a non-faradaic impedimetric ZnO nano-crystal biosensor

Cited by 18 publications

References 34 publications

Effect of Applied AC Voltage on the Performance of Non-Faradaic Impedimetric Biosensors

Effect of Applied AC Voltage on the Performance of Non-Faradaic Impedimetric Biosensors

Prospects of Biosensors Based on Functionalized and Nanostructured Solitary Materials: Detection of Viral Infections and Other Risks

CuZn Complex Used in Electrical Biosensors for Drug Delivery Systems

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