We study twisted products H = α r H r of natural autonomous Hamiltonians H r , each one depending on a separate set, called here separate r-block, of variables. We show that, when the twist functions α r are a row of the inverse of a block-Stäckel matrix, the dynamics of H reduces to the dynamics of the H r , modified by a scalar potential depending only on variables of the corresponding r-block. It is a kind of partial separation of variables. We characterize this block-separation in an invariant way by writing in block-form classical results of Stäckel separation of variables. We classify the block-separable coordinates of E 3 .We briefly recall the principal theorems regarding complete separation of the Hamilton-Jacobi equation, see [18] and [1] for further details. The theory of complete additive separation of the Hamilton-Jacobi equation begins with the work of Stäckel [28,29] about separability of the Hamilton-Jacobi equation in orthogonal coordinates. The Einstein summation convention on equal indices is understood, unless otherwise stated.