Equine Sarcoid: Epidemiology and its Clinical Impact in Working Donkeys in Selected Districts of Central Ethiopia

Gebre, Debebe; Gizachewu, Ayele; Negero, Jalel

doi:10.4172/2157-7579.1000537

Cited by 3 publications

(4 citation statements)

References 2 publications

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“…BPV antigens were detected immunohistochemically in the epidermal cells. It has been found that sarcoids in horses occur most frequently in the head-neck region (51%), trunk and genital region (32.3%), and leg and shoulder areas (16.1%) (Gebre et al, 2018). The localized development of tumors in horses can lead to functional disorders depending on the affected area.…”

Section: Discussionmentioning

confidence: 99%

“…The localized development of tumors in horses can lead to functional disorders depending on the affected area. As a result, animals may experience issues such as weakness, sensitivity, bleeding, blindness, difficulty in defecation and urination, locomotion problems, difficulties in parturition, feeding, and chewing (Gebre et al, 2018). Currently, there is no standardized method for the treatment of equine sarcoids.…”

Section: Discussionmentioning

confidence: 99%

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A different treatment approach for Bovine papillomavirus in an Arabian horse

ORTA,

KALE,

HASIRCIOĞLU

et al. 2023

Veterinary Journal of Mehmet Akif Ersoy University

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A wart lesion was observed near the anus of a female Arabian horse housed in a private equine facility in Bucak District of Burdur Province. During the histopathological examination of the mass, revealed equine sarcoid was revealed. Polymerase chain reaction (PCR) revealed the presence of bovine papillomavirus (BPV) type 10 and type 12 viral genomes in the tissue. It was observed that the combined treatment approach of PAPILEND™® cream + Zylexis™ + AlquermoldTM premix powder was beneficial in treating the sarcoid associated with BPV type 10 and type 12 on the anal region. No recurrence of the lesion was observed during the 6-month follow-up period. In conclusion, it is recommended to diagnose the presence of BPV in horses with warts and to investigate the efficacy of this combined treatment approach in larger populations.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A different treatment approach for Bovine papillomavirus in an Arabian horse

ORTA,

KALE,

HASIRCIOĞLU

et al. 2023

Veterinary Journal of Mehmet Akif Ersoy University

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“…In horses and other equids, skin-associated tumors are by far the most common form of cancer found in these species, with equine sarcoids (ES) accounting for an estimated 90% of all skin-associated neoplastic growths in equids [4, 5]. Although ES are usually not life-threatening, they can considerably compromise welfare, use, and value of affected individuals [6, 7]. Other skin tumors commonly found in horses include SCC and melanomas [8-10] (Table 1).…”

Section: Introductionmentioning

confidence: 99%

<b><i>Viscum album</i></b> L., a Therapeutic Option for Neoplastic Diseases in Companion Animals? A Systematic Review

Biegel¹,

Mevissen²,

Schüller³

et al. 2022

Complement Med Res

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Cancer is a common disease in humans and in companion animals and treatment is challenging. The aim of this systematic review was to identify and assess the potential use of Viscum album L. extracts (VAE) for treatment of neoplastic diseases in companion animals. Peer-reviewed animal, in vivo and in vitro studies were included, considering the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement and a measurement tool to assess systematic reviews (AMSTAR). Overall, 6,148 references were identified. Following a predefined protocol, 114 full-text references were assessed. Ultimately, 61 references were included for further assessment, 25 references included in vitro experiments, 26 included in vivo and clinical experiments and 10 references included both in vitro and in vivo experiments. These 61 references comprised data of 193 in vitro and 67 in vivo and clinical experiments. Most of the 67 in vivo and clinical experiments were conducted with mice (59), followed by rats (4), dogs (3) and horses (1). So far, oral melanomas, mammary tumors and sticker sarcomas in dogs, as well as sarcoids in horses, have been investigated in controlled clinical trials. A scoring system was established to evaluate the outcomes of each study based on defined effect levels. The efficacy of VAE treatment was most pronounced for melanomas, sarcomas, mammary carcinoma and equine sarcoids. The limited number and quality of published studies on VAE treatment in companion animals impedes to draw definitive conclusions regarding the efficacy of VAE in the treatment of cancer. Thus, further research is needed to elucidate the impact of VAE on the treatment of cancer in companion animals and possible underlying mechanisms.

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“…There is no strong connection between the skin and the subcutaneous tissue in case of type A nodules. Type B nodules have a clear skin lesion and the skin surface cannot move independently (Foy et al, 2002;Gebre et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Patho-histological features of fibroblastic sarcoid in horses

Portenko

Shchebentovska

2022

Regul. Mech. Biosyst.

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Sarcoid is one of the most common skin tumours, which is diagnosed in various breeds of horses at any age regardless of the animal’s sex. Such fibroblastic neoplasm manifests itself in several clinical ways with its specific morphological features. As a rule, it metastasizes rarely but can be locally invasive. The disease’setiology is multifactorial and includes the confirmed role of the bovine papillomavirus and genetic and environmental factors. The article introduces the results of a retrospective study of horses of the Ukrainian riding breed with a fibroblastic sarcoid type, which was localized mainly in the area of the external thoracic vein. Neoplasms were represented by two types. The first one included broad base neoplasms without a pronounced pedicle but with signs of hyperkeratosis. Massive rounded dense formations with an ulcerated surface refer to the second type. To verify the studied types of sarcoid, wide surgical excision of the lesion’svisible parts was performed, followed by the selection of fragments for the pathohistological diagnosis. Also, additional staining methods were used to detect the connective and muscle tissue (Van Gieson’s staining) and elastic fibers (Weigert’s resorcin-fuchsin staining). Microscopically, the neoplasm without a visible pedicle showed signs of hyperkeratosis and acanthosis in the peritumoral epidermal layer. Epidermis desquamation with a significant amount of oxyphilic detritus, diapedesis hemorrhages, and dilated vessels was also detected in some areas. Chaotic placement of fibroblasts and fibrocytes was noted, to a greater extent, subdermally. Anisocytosis and anisokaryosis were expressed moderately. Sarcoids, macroscopically presented in the form of massive dense formations with an ulcerated surface, were histologically characterized by the replacement of the epidermis with cellular elements, subdermal hemorrhages, and the characteristic perpendicular orientation of coarse collagen fibers towards the basement membrane. Closely spaced spindle-shaped cells with fibers forming moiré structures were visualized in the deep dermis layers. Nuclei were hyperchromic and elongated in shape, no atypical mitoses were noted. Pathohistological examination during the identification of a sarcoid type for diagnostic purposes can cause rapid growth and formation of an ulcer. The final diagnosis regarding equine sarcoid can be made based on a combination of clinical signs, histopathological examination, and molecular genetic testing with the isolation of BPV DNA.

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Equine Sarcoid: Epidemiology and its Clinical Impact in Working Donkeys in Selected Districts of Central Ethiopia

Cited by 3 publications

References 2 publications

A different treatment approach for Bovine papillomavirus in an Arabian horse

A different treatment approach for Bovine papillomavirus in an Arabian horse

<b><i>Viscum album</i></b> L., a Therapeutic Option for Neoplastic Diseases in Companion Animals? A Systematic Review

Patho-histological features of fibroblastic sarcoid in horses

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