Equine Pastern Dermatitis

Yu, Anthony

doi:10.1016/j.cveq.2013.09.003

Cited by 13 publications

(60 citation statements)

References 16 publications

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“…Equine pastern dermatitis (EPD) is one of the most frequently encountered skin disorders in equine practice. It is considered a syndrome rather than a disease entity and can result in a range of clinical signs, most typically including erythema, alopecia, scales, crusts, and thickening of the skin in the palmar and plantar regions of the pastern [ 1 – 3 ]. Its multifactorial nature not only complicates the scientific investigation of its pathogenesis, but in clinical practice it also impedes the identification of the relevant underlying cause(s) and the formulation of appropriate treatment approaches.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and WGS-based characteristics of Staphylococcus aureus in the nasal mucosa and pastern of horses with equine pastern dermatitis

et al. 2022

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Background Many contributing factors are involved in the development of equine pastern dermatitis (EPD). Among the most frequently suspected is Staphylococcus aureus, known for its pathogenic potential in skin and soft tissue infections. We therefore investigated the association between S. aureus carriage and EPD. Results One hundred five EPD-affected horses and 95 unaffected controls were examined for the presence of methicillin-resistant and -susceptible Staphylococcus aureus (MRSA and MSSA) on the pastern skin and in the nostrils. S. aureus isolates were cultivated from swab samples on selective MSSA and MRSA chromogenic agar and identified using MALDI-TOF MS. Isolates were analysed by Illumina whole genome sequencing for genetic relatedness (cgMLST, spa typing), and for the presence of antimicrobial resistance and virulence determinants. A markedly higher proportion of samples from EPD-affected horses proved positive for S. aureus, both from the pastern (59.0 % vs. 6.3 % in unaffected horses; P<0.001), and from the nose (59.0 % vs. 8.4 %; P<0.001). Isolates belonged to 20 sequence types (ST) with lineages ST15-t084 (spa) (18 %), ST1-t127 (13 %), and ST1-t1508 (12 %) being predominant. Eight S. aureus were MRSA ST398-t011 and ST6239-t1456, and contained the staphylococcal cassette chromosome SCCmecIVa. Antimicrobial resistance genes were almost equally frequent in pastern and in nasal samples, whereas some virulence factors such as the beta-hemolysin, ESAT-6 secretion system, and some enterotoxins were more abundant in isolates from pastern samples, possibly enhancing their pathogenic potential. Conclusions The markedly higher prevalence of S. aureus containing specific virulence factors in affected skin suggests their contribution in the development and course of EPD.

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Section: Introductionmentioning

confidence: 99%

Prevalence and WGS-based characteristics of Staphylococcus aureus in the nasal mucosa and pastern of horses with equine pastern dermatitis

et al. 2022

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“…Such persistent inflammation is observed regularly in EPD, yet its association with alterations in the local microbiota has not been investigated. Because EPD is frequently a recurrent condition, horses often are treated with various different products and classes of pharmacological and physical agents and therapies 7,8,21,22 …”

Section: Introductionmentioning

confidence: 99%

The skin microbiota in equine pastern dermatitis: a case‐control study of horses in Switzerland

Kaiser-Thom

Hilty

Axiak

et al. 2021

Veterinary Dermatology

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Background Equine pastern dermatitis (EPD), a multifactorial syndrome, manifests as skin lesions of variable severity in the pastern area. Despite the widespread use of antibacterial therapy for treating this condition, little is known about the contributing bacteria. Hypothesis/Objectives To investigate the bacterial skin microbiota in EPD‐affected and unaffected (control) pasterns. Animals Case‐control study with 80 client‐owned horses; each with at least one EPD‐affected and one control pastern. Methods and materials Horses were grouped by the form of EPD (mild, exudative or proliferative), the assigned severity grade and type of pretreatment (disinfectant, topical antibacterial or no antibacterial pretreatment). Skin swabs were obtained, and the microbiota composition was compared between the groups. Results Bacterial alpha diversity was reduced in affected pasterns (P < 0.001) and this reduction was significantly associated with the EPD forms (P < 0.001), and not with the type of pretreatment (P > 0.14). Analyses of beta‐diversity confirmed a disordering of the skin microbiota (P = 0.004) in affected versus control pasterns, that was particularly profound in more severe lesions. The type of pretreatment was not significantly associated with this disordering. Four differentially abundant families were detected, of which Staphylococcaceae was the most distinct. The relative abundance of staphylococci was significantly increased in affected pasterns (P = 0.011), particularly in those that had received antibacterial treatment previously. Conclusions and clinical relevance Changes in the microbiota are associated with the EPD form or severity of lesions. The role of bacteria in the pathogenesis of EPD as well as the propriety and consequences of antibacterial treatment should therefore be further investigated.

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“…Sie ist eine vermutlich immun-mediierte, photodynamisch aktivierte, kutane Vaskulitis an unpigmentierten Hautarealen der distalen Gliedmaßen. Sie tritt vor allem im Sommer auf und ist durch gut umschriebene, zirkuläre, schmerzhafte, erythomatöse, exsudative Krusten gekennzeichnet [2] (▶ Abb. 3).…”

Section: äTiologie Und Pathogeneseunclassified

“…Beim Kaltblut ist darüber hinaus eine Sonderform bekannt: die chronische Warzenmauke (verrucous pododer- . Bei der Warzenmauke führen unzureichende Lymphabflusssysteme der distalen Gliedmaße zu hochgradigen Schwellungen, zu Fibrosierungen, einer komprimierten Immunabwehr sowie sekundären Hautinfektionen [2,5,12].…”

Section: äTiologie Und Pathogeneseunclassified

Mauke beim Pferd

Hopster‐Iversen¹

2018

pferde spiegel

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Equine Pastern Dermatitis

Cited by 13 publications

References 16 publications

Prevalence and WGS-based characteristics of Staphylococcus aureus in the nasal mucosa and pastern of horses with equine pastern dermatitis

Prevalence and WGS-based characteristics of Staphylococcus aureus in the nasal mucosa and pastern of horses with equine pastern dermatitis

The skin microbiota in equine pastern dermatitis: a case‐control study of horses in Switzerland

Mauke beim Pferd

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