Equine-like G3 rotavirus in Hungary, 2015 – Is it a novel intergenogroup reassortant pandemic strain?

Dóró, Renáta; Marton, Szilvia; Bartókné, Anett Horváth; Lengyel, György; Agócs, Zsófia; Jakab, Ferenc; Bányai, Krisztiàn

doi:10.1556/030.63.2016.2.8

Cited by 69 publications

(63 citation statements)

References 19 publications

(33 reference statements)

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“…Although equine‐like G3P[8] strains have been found worldwide, the detection rates are quite different depending on the countries. Only a few equine‐like G3P[8] strains were detected in Germany, Hungary, Japan, Thailand, and the USA . In Australia and Spain, the detection rates were moderate: 14.4% to 37.6% .…”

Section: Discussionmentioning

confidence: 99%

“…Only a few equine-like G3P [8] strains were detected in Germany, Hungary, Japan, Thailand, and the USA. 11,17,[22][23][24][25] In Australia and Spain, the detection rates were moderate: 14.4% to 37.6%. 8,16 In contrast, equine-like G3P [8] strains were predominant in Brazil (71.4% in 2016 and 66.2% in 2017) 15,19 and Indonesia (85.7% in 2015-2016).…”

Section: Discussionmentioning

confidence: 99%

“…G3P[8] strains with a short RNA profile are described as DS‐1‐like (equine‐like) G3P[8] strains since their VP7 gene sequences are highly related to those of RVAs detected in horses . Recently, DS‐1‐like G1P[8] strains and equine‐like G3P[8] strains have spread worldwide …”

Section: Introductionmentioning

confidence: 99%

“…11,[13][14][15] Recently, DS-1-like G1P [8] strains and equine-like G3P [8] strains have spread worldwide. [8][9][10][11][12][14][15][16][17][18][19][20][21][22][23][24][25] In this study, we determined the G/P type distribution and carried out the full-genome characterization of two representative unusual equine-like G3P [8] strains which were highly prevalent (33.7%) in Thailand between January 2014 and September 2016. It is noteworthy that the equine-like G3P [8] strains with a short RNA profile that had been recently detected in several countries were predominant (65.3% to 89.8%) in various age groups across Thailand since 2015.…”

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confidence: 99%

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High prevalence of equine‐like G3P[8] rotavirus in children and adults with acute gastroenteritis in Thailand

Tacharoenmuang

Komoto

Guntapong

et al. 2019

Journal of Medical Virology

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Group A rotavirus (RVA) is a major cause of acute gastroenteritis in infants and young children worldwide. This study aims to clarify the distribution of G/P types and genetic characteristics of RVAs circulating in Thailand. Between January 2014 and September 2016, 1867 stool specimens were collected from children and adults with acute gastroenteritis in six provinces in Thailand. RVAs were detected in 514/1867 (27.5%) stool specimens. G1P[8] (44.7%) was the most predominant genotype, followed by G3P[8] (33.7%), G2P[4] (11.5%), G8P[8] (7.0%), and G9P[8] (1.3%). Unusual G3P[9] (0.8%), G3P[10] (0.4%), G4P[6] (0.4%), and G10P[14] (0.2%) were also detected at low frequencies. The predominant genotype, G1P[8] (64.4%), in 2014 decreased to 6.1% in 2016. In contrast, the frequency of G3P[8] markedly increased from 5.5% in 2014 to 65.3% in 2015 and 89.8% in 2016. On polyacrylamide gel electrophoresis, most (135/140; 96.4%) of the G3P[8] strains exhibited a short RNA profile. Successful determination of the nucleotide sequences of the VP7 genes of 98 G3P[8] strains with a short RNA profile showed that they are all equine‐like G3P[8] strains. On phylogenetic analysis of genome segments of two representative Thai equine‐like G3P[8] strains, it was noteworthy that they possessed distinct NSP4 genes, one bovine‐like and the other human‐like. Thus, we found that characteristic equine‐like G3P[8] strains with a short RNA electropherotype are becoming highly prevalent in children and adults in Thailand.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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High prevalence of equine‐like G3P[8] rotavirus in children and adults with acute gastroenteritis in Thailand

Tacharoenmuang

Komoto

Guntapong

et al. 2019

Journal of Medical Virology

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“…Although human G8 strains are particularly prevalent in Africa, they have been infrequently detected elsewhere [25, 31]. In 2015, the emergence of DS-1-like G3P[8] strains (including strains ERN8263 and SS96217158) was recognized in Hungary and Spain, Europe [21, 23]. …”

Section: Introductionmentioning

confidence: 99%

Full Genome Characterization of Novel DS-1-Like G8P[8] Rotavirus Strains that Have Emerged in Thailand: Reassortment of Bovine and Human Rotavirus Gene Segments in Emerging DS-1-Like Intergenogroup Reassortant Strains

et al. 2016

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The emergence and rapid spread of unusual DS-1-like intergenogroup reassortant rotavirus strains have been recently reported in Asia, Australia, and Europe. During rotavirus surveillance in Thailand in 2013–2014, novel DS-1-like intergenogroup reassortant strains having G8P[8] genotypes (i.e., strains KKL-17, PCB-79, PCB-84, PCB-85, PCB-103, SKT-107, SWL-12, NP-130, PCB-656, SKT-457, SSKT-269, and SSL-55) were identified in stool samples from hospitalized children with severe diarrhea. In this study, we determined and characterized the complete genomes of these 12 strains (seven strains, KKL-17, PCB-79, PCB-84, PCB-85, PCB-103, SKT-107, and SWL-12, found in 2013 (2013 strains), and five, NP-130, PCB-656, SKT-457, SSKT-269, and SSL-55, in 2014 (2014 strains)). On full genomic analysis, all 12 strains showed a unique genotype constellation comprising a mixture of genogroup 1 and 2 genes: G8-P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2. With the exception of the G genotype, the unique genotype constellation of the 12 strains (P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2) was found to be shared with DS-1-like intergenogroup reassortant strains. On phylogenetic analysis, six of the 11 genes of the 2013 strains (VP4, VP2, VP3, NSP1, NSP3, and NSP5) appeared to have originated from DS-1-like intergenogroup reassortant strains, while the remaining four (VP7, VP6, VP1, and NSP2) and one (NSP4) gene appeared to be of bovine and human origin, respectively. Thus, the 2013 strains appeared to be reassortant strains as to DS-1-like intergenogroup reassortant, bovine, bovine-like human, and/or human rotaviruses. On the other hand, five of the 11 genes of the 2014 strains (VP4, VP2, VP3, NSP1, and NSP3) appeared to have originated from DS-1-like intergenogroup reassortant strains, while three (VP7, VP1, and NSP2) and one (NSP4) were assumed to be of bovine and human origin, respectively. Notably, the remaining two genes, VP6 and NSP5, of the 2014 strains appeared to have originated from locally circulating DS-1-like G2P[4] human rotaviruses. Thus, the 2014 strains were assumed to be multiple reassortment strains as to DS-1-like intergenogroup reassortant, bovine, bovine-like human, human, and/or locally circulating DS-1-like G2P[4] human rotaviruses. Overall, the great genomic diversity among the DS-1-like intergenogroup reassortant strains seemed to have been generated through additional reassortment events involving animal and human strains. Moreover, all the 11 genes of three of the 2014 strains, NP-130, PCB-656, and SSL-55, were very closely related to those of Vietnamese DS-1-like G8P[8] strains that emerged in 2014–2015, indicating the derivation of these DS-1-like G8P[8] strains from a common ancestor. To our knowledge, this is the first report on full genome-based characterization of DS-1-like G8P[8] strains that have emerged in Thailand. Our observations will add to our growing understanding of the evolutionary patterns of emerging DS-1-like intergenogroup reassortant strains.

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Characterization of unusual DS‐1‐like G3P[8] rotavirus strains in children with diarrhea in Japan

Komoto

Ide

Negoro

et al. 2018

Journal of Medical Virology

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The emergence and rapid spread of novel DS-1-like intergenogroup reassortant rotaviruses having the equine-like G3 genotype (DS-1-like G3P[8] strains) have been recently reported from several countries. During rotavirus surveillance in Japan in 2015-2016, three DS-1-like G3P[8] strains were identified from children with severe diarrhea. In the present study, we sequenced and characterized the full genomes of these three strains. On full-genomic analysis, all three strains showed a unique genotype constellation including both genogroup 1 and 2 genes: G3-P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2. Phylogenetic analysis revealed that each of the 11 genes of the three strains was closely related to that of Japanese DS-1-like G1P[8] and/or Japanese equine-like G3P[4] human strains. Thus, the three study strains were suggested to be reassortants that acquired the G3-VP7 gene from equine G3 rotaviruses on the genetic background of DS-1-like G1P[8] strains. Our observations will provide important insights into the evolutionary dynamics of emerging DS-1-like G3P[8] strains.

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Equine-like G3 rotavirus in Hungary, 2015 – Is it a novel intergenogroup reassortant pandemic strain?

Cited by 69 publications

References 19 publications

High prevalence of equine‐like G3P[8] rotavirus in children and adults with acute gastroenteritis in Thailand

High prevalence of equine‐like G3P[8] rotavirus in children and adults with acute gastroenteritis in Thailand

Full Genome Characterization of Novel DS-1-Like G8P[8] Rotavirus Strains that Have Emerged in Thailand: Reassortment of Bovine and Human Rotavirus Gene Segments in Emerging DS-1-Like Intergenogroup Reassortant Strains

Characterization of unusual DS‐1‐like G3P[8] rotavirus strains in children with diarrhea in Japan

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