Equine Infectious Anemia Virus
            <i>gag</i>
            and
            <i>pol</i>
            Genes: Relatedness to Visna and AIDS Virus

Stephens, Robert M.; Casey, James W.; Rice, Nancy R.

doi:10.1126/science.3003905

Cited by 230 publications

(141 citation statements)

References 31 publications

(6 reference statements)

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“…Polyclonal rabbit antibodies to either of these viruses bound specifically to the FIV p28 polypeptide, which may represent the FIV major core protein. The results of these molecular and serologic analyses are consistent with the observed conservation of gag-pol genes across the lentivirus subfamily (20,32,33).…”

Section: Resultssupporting

confidence: 74%

Molecular cloning of feline immunodeficiency virus.

Olmsted

Barnes

Yamamoto

et al. 1989

Proc. Natl. Acad. Sci. U.S.A.

140

110

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Feline immunodeficiency virus (FIV) is a T-lymphotropic retrovirus associated with immunodeficiency and opportunistic infections in cats. The discovery of FIV provides an opportunity for the development of a small animal model for AIDS. To initiate the molecular and biological characterization of FIV, cDNA clones were synthesized and used to isolate a proviral clone of FIV. Molecular cross-hybridization analysis of FIV with five lentiviruses revealed that nucleotide-sequence similarities exist between FIV and these lentiviruses in the gag-pol genes. However, nucleotide-sequence similarities were not seen upon comparison of the FIV long terminal repeat sequence with known viral sequences. Common antigenic determinants appeared to be shared by FIV, caprine arthritis encephalitis virus, and visna virus as shown by serological cross-reactivity of rabbit antibodies to caprine arthritis encephalitis virus and visna virus with the putative FIV core protein p28. These studies demonstrated that FIV is a member of the lentivirus subfamily and is distantly related to the AIDS lentiviruses of primates. Importantly, progeny virions of our molecular clone were infectious for experimentally inoculated cats. The availability of an infectious molecular clone will make possible a detailed dissection of the molecular pathogenesis of FIV, which may facilitate the development of vaccine and therapeutic strategies for AIDS.

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Section: Resultssupporting

confidence: 74%

Molecular cloning of feline immunodeficiency virus.

Olmsted

Barnes

Yamamoto

et al. 1989

Proc. Natl. Acad. Sci. U.S.A.

140

110

View full text Add to dashboard Cite

show abstract

“…The assembly of Gag precursor proteins on the plasma membrane is essential for virus budding from the host cells. The EIAV Gag-precursor (Pr55 gag ) polyprotein is cleaved by viral protease into four major internal structural proteins of the mature virion: the membrane-interacting matrix (MA) p15, the capsid (CA) p26, the RNA-binding nucleocapsid (NC) proteins p11 and p9 [62,163] (Fig. 1A).…”

Section: The Structural Proteins Of Eiavmentioning

confidence: 99%

Equine Infectious Anemia Virus (EIAV): what has HIV?s country cousin got to tell us?

2004

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-Equine Infectious Anemia Virus (EIAV) is a lentivirus, of the Retrovirus family, with an almost worldwide distribution, infecting equids. It causes a persistent infection characterized by recurring febrile episodes associating viremia, fever, thrombocytopenia, and wasting symptoms. The disease is experimentally reproducible by inoculation of Shetland ponies or horses with EIAV pathogenic strains. Among lentiviruses, EIAV is unique in that, despite a rapid virus replication and antigenic variation, most animals progress from a chronic stage characterized by recurring peaks of viremia and fever to an asymptomatic stage of infection. The inapparent carriers remain infective for life, as demonstrated by experimental transfer of blood to naive animals. The understanding of the correlates of this immune control is of great interest in defining vaccine strategies. Research on EIAV, this "country cousin" of HIV (Human Immunodeficiency Virus), over the last five decades has produced some interesting results on natural immunological control of lentivirus replication and disease and on the nature and role of virus variation in persistence and pathogenesis. These studies are of interest in the context of HIV and efforts to develop a vaccine. This review will focus on some of the most recent results. equine infectious anemia virus / lentivirus / equids / vaccine / viral evolution

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“…1985) isolated in France, LAVELI and LAVMAL (Alizon et al 1986) in Africa (Zaire), BH5, BH10 (Ratner et al 1985), and pv.22 (Meusing et al 1985) in New York, and ARV2 (Sanchez-Pescador et at. 1985) in San Francisco, lentiviruses; equine infectious anemia virus (EIAV) (Stephens et al 1986) and visna lentivirus (VISNA) (Sonigo et al 1985), and oncoviruses; human T cell leukemia virus type I (HTLV-I) (Seiki et al 1983), type I I ( HTLV-I I ) (Shimotohno et al 1984), bovine leukemia virus (BLV) (Sagata et al 1985), Moloney murine leukemia virus (MMLV) (Shinnick et al 1981), Rous sarcoma virus (RSV) (Schwarz et al 1983), and mouse mammary tumor virus (MMTV) (Chiu et al 1985).…”

Section: Molecular Phylogeny O F the Human Immunodeficiency And Relatmentioning

confidence: 99%