Equine Hepatic Encephalopathy

Hurcombe, Samuel D.A.

doi:10.1002/9780470376461.ch20

Cited by 5 publications

(3 citation statements)

References 35 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Typical clinical findings in foals and other species with PSSs are congenital lethargy, disorientation, compulsive circling, ptyalism, central blindness and bruxism (Hurcombe ). Clinicopathological findings commonly seen are anaemia, microcytosis, raised serum ammonia and bile acids, reduced urea, plasma protein and albumin (Hug et al .…”

Section: Discussionmentioning

confidence: 99%

Surgical management of an extrahepatic portosystemic shunt in a foal: A multidisciplinary problem

Woodford¹,

Moore²,

Renfrew³

et al. 2015

Equine Veterinary Education

View full text Add to dashboard Cite

Summary A 5‐week‐old American Miniature filly was referred due to intermittent neurological signs of 4 weeks' duration. Clinicopathological findings showed increased ammonia and bile acids in venous blood samples. Abdominal ultrasonography detailed a portosystemic shunt (PSS). The foal underwent laparotomy and operative mesenteric portovenography, which further defined the PSS as extrahepatic portocaval in configuration. The PSS was occluded and intraoperative portovenography confirmed successful shunt occlusion. The foal made a good recovery from surgery and had a successful showing career until she succumbed to colic just over 3 years after surgery.

show abstract

Section: Discussionmentioning

confidence: 99%

Surgical management of an extrahepatic portosystemic shunt in a foal: A multidisciplinary problem

Woodford¹,

Moore²,

Renfrew³

et al. 2015

Equine Veterinary Education

View full text Add to dashboard Cite

show abstract

“…In horses with hepatic encephalopathy, treatment is often difficult and the disease progresses. Clinical signs of hepatic encephalopathy are a result of neuronal damage in cerebrum, brain stem and/or cerebellum and, in horses, usually include abnormal behaviour, depression, aggression, yawning, pacing, blindness, aimless wandering, head pressing, somnolence, ataxia and recumbency (Hurcombe 2008).…”

Section: Clinical Commentarymentioning

confidence: 99%

“…All these substances may result in pathophysiological processes such as glutamate (NMDA)‐receptor‐mediated excitotoxity, oxidative/nitrosative stress, neuroinflammation, ATP depletion, alteration of the blood‐brain barrier permeability and alteration of neurohormone and neurotransmitter concentrations. It is likely that the development of hepatic encephalopathy has a multifactorial aetiology (for a more detailed description of these pathogenetic mechanisms see recent reviews by Butterworth [2007, 2010] and Hurcombe [2008]).…”

Section: Clinical Commentarymentioning

confidence: 99%

Gait deficits in liver disease: Hepatic encephalopathy and hepatic myelopathy

Nout

2010

Equine Veterinary Education

View full text Add to dashboard Cite

Summary In this issue, the unusual clinical presentation of a horse diagnosed is described with severe liver cirrhosis and hepatic encephalopathy. The horse initially presented for thoracic and pelvic limb ataxia and weakness, and signs of forebrain disease were not apparent until later in the disease process. The typical pathology of central nervous system disease associated with liver disease is related to encephalopathy and forebrain disease; however, the spinal cord is occasionally also involved. Hepatic myelopathy is a rare syndrome usually associated with surgical or acquired portosystemic shunts, liver cirrhosis and/or portal hypertension in man. Where a gliopathy is the most prominent pathological feature seen in hepatic encephalopathy, in hepatic myelopathy the most remarkable feature is demyelination of the corticospinal tracts of the distal cervical and thoracic spinal cord with occasional axon loss. The clinical signs of hepatic myelopathy are spastic paresis/paralysis with normal sensory findings and preserved sphincter function. The prognosis for hepatic myelopathy is generally poor. In summary, in severe liver disease, motor deficits can occur secondary to the encephalopathy, but motor deficits can also occur as a result of spinal cord pathology such as seen in hepatic myelopathy. In examination of horses with myelopathies, liver disease as a cause of myelopathy should be included in our list of differentials.

show abstract

Treatment of equine nervous system disorders

Cole¹,

Bentz

2014

Equine Pharmacology

View full text Add to dashboard Cite

Equine Hepatic Encephalopathy

Cited by 5 publications

References 35 publications

Surgical management of an extrahepatic portosystemic shunt in a foal: A multidisciplinary problem

Surgical management of an extrahepatic portosystemic shunt in a foal: A multidisciplinary problem

Gait deficits in liver disease: Hepatic encephalopathy and hepatic myelopathy

Treatment of equine nervous system disorders

Contact Info

Product

Resources

About