Equine gammaherpesviruses: Pathogenesis, epidemiology and diagnosis

Fortier, Guillaume; Erck, Emmanuelle Van; Pronost, Stéphane; Lekeux, Pierre; Thiry, Étienne

doi:10.1016/j.tvjl.2009.08.017

Cited by 69 publications

(88 citation statements)

References 124 publications

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“…The family Herpesviridae is divided into three subfamilies: Alphaherpesvirinae, Betaherpesvirinae and Gammaherpesvirinae , where EHV-5 together with EHV-2 and EHV-7 (also called asinine herpes virus −2 [1]) are classified as equine gammaherpesviruses [2]. EHV-5 was first isolated in the seventies from two horses in quarantine in Australia with clinical signs of upper respiratory tract disease [3].…”

Section: Introductionmentioning

confidence: 99%

Equine Multinodular Pulmonary Fibrosis in association with asinine herpesvirus type 5 and equine herpesvirus type 5: a case report

et al. 2012

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A standardbred gelding with a history of 10 days pyrexia and lethargy was referred to the Equine Hospital at the Swedish University of Agricultural Sciences in Uppsala, Sweden.The horse had tachypnea with increased respiratory effort and was in thin body condition. Laboratory findings included leukocytosis, hyperfibrinogenemia and hypoxemia. Thoracic radiographs showed signs of pneumonia with a multifocal nodular pattern, which in combination with lung biopsy findings indicated Equine Multinodular Pulmonary Fibrosis (EMPF). EMPF is a recently described disease in adult horses with clinical signs of fever, weight loss and respiratory problems. The pathological findings include loss of functional pulmonary parenchyma due to extensive nodular interstitial fibrosis which has been related to infection with the equine herpesvirus type 5 (EHV-5). In this case, lung biopsy and tracheal wash samples tested positive for both asinine herpesvirus type 5 (AHV-5) and EHV-5 using PCR assays. The horse failed to respond to treatment and was euthanized for humane reasons. Postmortem examination confirmed the diagnosis of EMPF. This case suggests that not only EHV-5 alone should be considered in association with the development of this disease.

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Section: Introductionmentioning

confidence: 99%

Equine Multinodular Pulmonary Fibrosis in association with asinine herpesvirus type 5 and equine herpesvirus type 5: a case report

et al. 2012

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“…The glycoprotein gD had been used as an antigenic target for EHV‐1; similarly, the primary antigenic target used in identifying EHV‐5 has been the gB glycoprotein (Fortier et al . ). Currently, while support for EHV‐5 as a cause of EMPF is quite strong, the role of EHV‐5 in EMPF remains somewhat controversial.…”

mentioning

confidence: 97%

“…EHV‐5 is incredibly slow to grow in culture, requiring 4 passages for the cytopathic effect to be reliably observed, making infection and antiviral sensitivity testing studies particularly challenging (Fortier et al . ; Marenzoni et al . ).…”

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confidence: 99%

Equine multinodular pulmonary fibrosis: Diagnosis and treatment

Wilkins

2013

Equine Veterinary Education

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“…Both LpaGHV1 and LruGHV2 were detected in animals without known disease, though GHVs have been associated with lymphoproliferative disease and a variety of other conditions (Ackermann 2006). Notably among the percaviruses, EHV2 and EHV5 have been linked to equine respiratory disease and poor performance (Fortier et al 2010). Among the carnivoreassociated percaviruses, fisher herpesvirus and mustelid herpesvirus 2 were isolated from animals with ulcerative lesions (Gagnon et al 2011;Tseng et al 2012), and FcaGHV1 was associated with poor health condition and increased incidence of FIV infection in cats .…”

mentioning

confidence: 99%

Identification of Novel Gammaherpesviruses in Ocelots (Leopardus pardalis) and Bobcats (Lynx rufus) in Panama and Colorado, USA

Lozano

Sweanor

Wilson-Henjum

et al. 2015

Journal of Wildlife Diseases

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ABSTRACT:Gammaherpesviruses (GHVs) have been identified in many species and are often associated with disease. Recently, we characterized three novel felid GHVs in domestic cats (Felis catus), bobcats (Lynx rufus), and pumas (Puma concolor). We investigated whether freeranging ocelots (Leopardus pardalis) and bobcats are infected with additional GHVs. We screened DNA samples from ocelots on Barro Colorado Island, Panama, and bobcats in western Colorado, US, by using a degenerate nested PCR that targets the GHV glycoprotein B gene. We identified a novel GHV glycoprotein B sequence in two ocelots and a second novel sequence in a bobcat, which is distinct from the previously characterized bobcat GHV (Lynx rufus GHV 1). Utilizing additional degenerate and virus-specific PCRs, we extended these sequences to include 3.4 kilobases of the GHV glycoprotein B and DNA polymerase genes. These sequences identify the first GHV detected in ocelots and the second GHV in bobcats. These viruses were provisionally named L. pardalis GHV 1 and Lynx rufus GHV 2, respectively. The viruses are most closely related to recently identified GHVs of the Percavirus genus found in domestic cats (F. catus GHV 1) and bobcats (L. rufus GHV 1), suggesting that a cluster of felid GHVs exists within the Percavirus genus.

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Equine gammaherpesviruses: Pathogenesis, epidemiology and diagnosis

Cited by 69 publications

References 124 publications

Equine Multinodular Pulmonary Fibrosis in association with asinine herpesvirus type 5 and equine herpesvirus type 5: a case report

Equine Multinodular Pulmonary Fibrosis in association with asinine herpesvirus type 5 and equine herpesvirus type 5: a case report

Equine multinodular pulmonary fibrosis: Diagnosis and treatment

Identification of Novel Gammaherpesviruses in Ocelots (Leopardus pardalis) and Bobcats (Lynx rufus) in Panama and Colorado, USA

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