Equine congenital cutaneous papillomatosis: A report of 5 cases

Garma-Aviña, Armando; Valli, V. E.; Lumsden, J. H.

doi:10.1111/j.2042-3306.1981.tb03455.x

Cited by 15 publications

(16 citation statements)

References 4 publications

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“…[1][2][3] In utero infection by a latent papillomavirus in the dam has been proposed as a possible cause. 1,[4][5][6][7][8] A study that included five cases of equine congenital papilloma found no immunohistochemical evidence of papillomavirus, 6 which supports the suggestion that these lesions are a form of epidermal nevus. 3 The purpose of this study is to describe gross pathological and histopathological findings and results of immunohistochemistry for detection of papillomavirus in five additional cases of equine congenital papilloma, including one case in a foetus.…”

Section: Introductionmentioning

confidence: 71%

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Equine congenital papilloma: pathological findings and results of papillomavirus immunohistochemistry in five cases

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Fuji

Valentine

et al. 2004

Veterinary Dermatology

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Congenital cutaneous papillomas were identified in five foals. Age at diagnosis ranged from 305 days' gestation to 2 days of age. Breeds were thoroughbred (2), standard-bred (1), warmblood (1) and paint (1). Two were female, one was male and the gender of two cases was not specified. Masses were pedunculated with a roughened, wart-like (verrucous) or a smoother, cauliflower-like surface. Masses occurred as single lesions on the forelimb, lip and face, or as multiple lesions on the trunk. Histological features included relatively uniform epidermal papillary hyperplasia with variable melanin pigment within basal layers and vacuolization of keratinocytes in all layers, but with no evidence of nuclear or cytoplasmic changes (koilocytes) characteristic of viral infection. One case showed epidermal proliferation with proliferation of pilosebaceous units. Results of immunohistochemical studies for the detection of papillomavirus antigens were negative in all cases. These results suggest that equine congenital papilloma may be a hamartomatous lesion (epidermal nevus) and not a viral-induced growth.

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Section: Introductionmentioning

confidence: 71%

“…Congenital squamous papilloma occurs most often in horses. [1][2][3][4][5][6][7][8][9] Congenital fibropapilloma occurs rarely in pigs 13 and cattle. 14 The gross pathological findings in these five cases of equine congenital papilloma are similar to those described previously.…”

Section: Discussionmentioning

confidence: 99%

Equine congenital papilloma: pathological findings and results of papillomavirus immunohistochemistry in five cases

White

Fuji

Valentine

et al. 2004

Veterinary Dermatology

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“…This form may occur in an enzootic form (5 (18,42) or not recognized (56). It is conceivable however, that papillomavirus might occasionally exist in a latent form in utero and becomes manifest when fetal skin attains a critical level of maturation (56 (23,28,29,69).…”

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confidence: 99%

Congenital tumours and tumour‐like lesions in domestic animals. 3. Horses. A review

Misdorp

2003

Veterinary Quarterly

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“…In particular, bovine papilloma virus (BPV) types 1, 2, and 5 induce fibropapilloma of the skin in cattle [4,6]. Congenital papillomas are considered non-infectious lesions that most often occur in horses [5,14,17]. In a previous report on porcine congenital papilloma, the presence of virus was not found on electron microscopy, but there have been no studies using immunohistochemistry or polymerase chain reaction (PCR) to assess for viral involvement [16].…”

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Congenital Cutaneous Fibropapillomatosis with No Evidence of Papillomavirus Infection in a Piglet

Nishiyama

Akiba

Kobayashi

et al. 2011

The Journal of Veterinary Medical Science

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ABSTRACT. Multiple yellowish-white, cauliflower-like mass lesions on the skin of the head and back in a 4-month-old piglet were pathologically examined. These lesions had developed before the weaning period. Histologically, the cutaneous neoplasms were characterized by papillary outgrowth of connective tissue covered by thick epidermis. Hyperplasia of the epidermis was corresponded with proliferation of capillaries, lympho-plasmacytic infiltration, and proliferation of fibroblasts in the dermal stroma. There were no inclusion bodies and significant degeneration in the keratinocytes. Papillomavirus antigen and DNA were not detected in these lesions by immunohistochemistry and polymerase chain reaction, respectively. Accordingly, the fibropapillomatosis of the present case might be hamartomatous rather than infectious.KEY WORDS: dermatopathology, fibropapilloma, hamartoma, pathology, swine.J. Vet. Med. Sci. 73(2): 283-285, 2011 Cutaneous papilloma is rare in pigs, and two patterns of the lesion have been reported: transmissible genital papilloma and congenital fibropapilloma [7,13]. Only two cases of porcine congenital papilloma have been reported, and the involvement of viral infection in the cutaneous lesion has not been confirmed [11,16].In animals and humans, some forms of cutaneous papilloma are caused by papillomavirus (PV). In particular, bovine papilloma virus (BPV) types 1, 2, and 5 induce fibropapilloma of the skin in cattle [4,6]. Congenital papillomas are considered non-infectious lesions that most often occur in horses [5,14,17]. In a previous report on porcine congenital papilloma, the presence of virus was not found on electron microscopy, but there have been no studies using immunohistochemistry or polymerase chain reaction (PCR) to assess for viral involvement [16]. We recently encountered cutaneous papillomatosis in a piglet. In this report, we describe the histopathological features and the results of immunohistochemistry and PCR for PV.A hybrid piglet developed multiple, yellowish-white, cauliflower-like tumors on the skin of the head and back. According to the owner, these lesions had been observed from the suckling period (Fig. 1), and the animal had not shown any other significant clinical abnormalities. The pig was sacrificed at 4 months of age and the liver, intestine, lymph nodes, and 4 tumors were submitted to our laboratory for pathological examinations. The largest tumor among those submitted was approximately 8.0 × 7.0 × 5.0 cm in size and was hard, creamy white, and pedunculated on cut section (Fig. 2).Tissue samples were fixed in 10% neutral-buffered formalin and embedded in paraffin wax. The sections (4 μm) were cut and stained with hematoxylin and eosin (HE). For immunohistochemical examination, a standard peroxidaseantiperoxidase technique was used on the paraffin sections with primary antibodies as rabbit polyclonal anti-bovine papillomavirus (BPV-1) (DakoCytomation, Carpinteria, CA, U.S.A.) and mouse monoclonal anti-proliferating cell nuclear antigen (PCNA) (clone PC10; DAKO...

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Equine congenital cutaneous papillomatosis: A report of 5 cases

Cited by 15 publications

References 4 publications

Equine congenital papilloma: pathological findings and results of papillomavirus immunohistochemistry in five cases

Equine congenital papilloma: pathological findings and results of papillomavirus immunohistochemistry in five cases

Congenital tumours and tumour‐like lesions in domestic animals. 3. Horses. A review

Congenital Cutaneous Fibropapillomatosis with No Evidence of Papillomavirus Infection in a Piglet

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