Equine amniotic membrane transplantation for corneal ulceration and keratomalacia in three horses

Lassaline, Mary; Brooks, Dennis; Ollivier, Franck J.; Komàromy, András M.; Källberg, M. E.; Gelatt, Kirk N.

doi:10.1111/j.1463-5224.2005.00405.x

Cited by 66 publications

(100 citation statements)

References 27 publications

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“…Some reported that human AM used for corneal reconstruction in the human patient was disintegrated (Sridhar et al 2001) or dissolved Letko et al 2001;Rodriguez-Ares et al 2004). Lassaline et al (2005) had used equine AM for corneal reconstruction in 3 horses with corneal ulceration and keratomalacia, and found that the membrane sloughed off over 4-to 6-week period. The AM was unable to be incorporated because the ulcers were infected and malacic.…”

Section: Discussionmentioning

confidence: 98%

“…Human AM (Kim and Tseng 1995;Tuntivanich and Tuntivanich 2006;Wichayacoop et al 2005), equine AM (Barros et al 1998;Lassaline et al 2005;Ollivier et al 2006), and canine AM (Barros et al 2005) have been used as either a xenograft or an allograft for corneal reconstruction in animals. The AM allografts were also effective in corneal reconstruction after the excision of large neoplasias in 16 human patients , 1 dog (Barros et al 2005), and 9 horses (Ollivier et al 2006).…”

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confidence: 97%

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Canine amniotic membrane transplantation for corneal reconstruction after the excision of dermoids in dogs

et al. 2009

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Transplantation of canine amniotic membrane (AM) in conjunction with a third eyelid flap was performed after the removal of large dermoids by keratectomy and conjunctivectomy on 7 eyes of 7 dogs. Corneal epithelialization was completed within 2 weeks after the transplantation. Five eyes attained normal transparency of the cornea within 5 weeks. Slight pigmentation of the bulbar conjunctiva at the limbus was observed in 1 dog that had pre-existing pigmentary keratitis. Neovascularization and scarring of the cornea and impaired vision were not found in any dogs at 8 weeks after the transplantation. In conclusion, transplantation of canine AM can promote corneal healing after the excision of large dermoids in dogs.

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Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 97%

Canine amniotic membrane transplantation for corneal reconstruction after the excision of dermoids in dogs

et al. 2009

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“…Various biomaterials have also been used to repair corneal injuries including amniotic membrane (Lassaline et al . ; Plummer ), submucosa of porcine small intestine (Goulle ) and extracellular matrix of porcine bladder (ACell Vet corneal discs) (Balland et al . ; Mancuso et al .…”

Section: Introductionmentioning

confidence: 99%

The use of porcine urinary bladder matrix (UBM) to repair a perforated corneal ulcer with iris prolapse in a horse

Davis

Riggs

Chow³

2017

Equine Veterinary Education

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Summary This report describes the use of porcine urinary bladder matrix (UBM) to repair a full thickness defect in the cornea of a Thoroughbred racehorse. The horse presented with acute keratomalacia of the right eye of 12 h duration that had rapidly progressed to perforation of the cornea with partial iris prolapse. The cornea was surgically debrided with the horse under general anaesthesia and the defect repaired with ACell multilayer wound matrix. A temporary tarsorrhaphy was performed. The defect in the cornea was successfully repaired and the horse regained vision in the eye. Four months after surgery the defect was still undergoing remodelling and the area of opacity in the cornea was progressively reducing.

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“…In veterinary medicine its utility has been growing. For instance, it has been already used to repair full-thickness defects of the cornea of dogs (Barros et al 1998), generalized keratomalacia, ankyloblepharon, and after fibrous histiocytoma removal in two dogs and a cat (Barros et al 2005), to reconstruct corneal surface after excision of corneolimbal squamous cell carcinomas in nine horses (Olliver et al 2006), and to repair corneal ulceration and keratomalacia in three horses (Lassaline et al 2005).…”

Section: Discussionmentioning

confidence: 99%

Effects of topical 0.2% Cyclosporine A on corneal neovascularization induced by xenologous amniotic membrane implantation into a corneal stroma micropocket of rats

et al. 2008

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RESUMO.-[Efeitos do uso tópico da Ciclosporina A (CsA) 0,2% na neovascularização corneal induzida pelo implante de membrana amniótica xenógena em microbolsa no estroma da córnea de ratos.] Este estudo teve como objetivo a avaliação dos efeitos tópicos da Ciclosporina a 0,2% (CsA) sobre a neovascularização corneana de ratos após implante cirúrgico de membrana amniótica eqüina em microbolsa do estroma corneana. O implante da membrana foi feito bilateralmente em 90 ratos. O tratamento com The objective of the study was to evaluate the topical effects of 0.2% Cyclosporine A (CsA) on corneal neovascularization of rats following surgical implantation of equine amniotic membrane into a corneal stroma micropocket. The implantation of xenologous amniotic membrane was performed bilaterally in 90 rats. In the same day of the surgery each right eye started receiving topical CsA twice a day. The left eye received no medication and served as a control. The evaluation of corneal neovascularization was performed by computerized image analysis and histopathological evaluation at 1, 3, 7, 15, 30 and 60 days postoperatively. For the image analysis 10 animals were used per time period, and for the histopathological examination, five animals were used per time period. Image analysis found that corneal neovascularization began on the 3rd postoperative day, reached its peak on the 7th day, and then progressively and rapidly decreased. Statistic analysis indicated that neovascularization of the CsA treated eye on the 7th day was significantly higher than that observed in untreated eyes. On the 30th day, however, this pattern was reversed with the neovascularization observed in the CsA treated eyes declining to the low levels observed on the 3rd day. The degree of neovascularization in the untreated eyes on the 30th day declined to the baseline levels found on day 3 at the 60th day. Histopathological analysis indicated that deposition of collagen in the implanted tissue was completed by the 15th day. Therefore, we concluded that (1) equine amniotic membrane in rat corneal stroma produced an intense neovascularization until the 15th day postoperatively and then regressed, (2) deposition of collagen of the implanted tissue was completed on the 15th day postoperatively, and (3) use of CsA was associated with increase in the corneal neovascularization initially, followed by a quick and intense regression. CsA iniciou-se no mesmo dia da cirurgia, nos olhos direitos dos animais, duas vezes ao dia. Os olhos esquerdos não receberam nenhum tratamento e serviram de controle. A avaliação da neovascularização corneana foi feita por análi-se de imagem computadorizada e por exame histopatológi-co aos dias 1, 3, 7, 15, 30 e 60 de pós-cirúrgico. Para a análise de imagem foram utilizados 10 animais por período, e para o exame histopatológico, 5 por período. A análise de imagem demonstrou que a neovascularização iniciou-se no 3° dia pós-cirúrgico, alcançou seu pico no 7° dia e então regrediu rápida e progressivamente até o 60° dia. A análise estatística ...

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Equine amniotic membrane transplantation for corneal ulceration and keratomalacia in three horses

Abstract: Results of a small number of equine AMT suggest that amnion can be used successfully to preserve both globe structure and limited vision, as well as optimize cosmesis, in horse eyes with corneal ulceration and severe keratomalacia.

Cited by 66 publications

References 27 publications

Canine amniotic membrane transplantation for corneal reconstruction after the excision of dermoids in dogs

Canine amniotic membrane transplantation for corneal reconstruction after the excision of dermoids in dogs

The use of porcine urinary bladder matrix (UBM) to repair a perforated corneal ulcer with iris prolapse in a horse

Effects of topical 0.2% Cyclosporine A on corneal neovascularization induced by xenologous amniotic membrane implantation into a corneal stroma micropocket of rats

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