Equine adipose-derived stem cell (ASC) expresses BAFF and its receptors, which may be associated with the differentiation process of ASC towards adipocyte

Wu, Haitao; Han, Dongju; Jiang, Zheng-an; Zhao, Dongwei; Liu, Meng; Xu, Xingzhou; Liu, Xia; Yang, Lin; Ji, Xuemei; Wang, Mingyan; Zhang, Shuangquan

doi:10.1016/j.intimp.2013.12.018

Cited by 6 publications

(2 citation statements)

References 33 publications

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“…The biology of mesenchymal stem cells from adipose tissue was studied in several animal species considering their use in cell therapy, including mice (Jang et al, 2011), rat (Schuh et al, 2014), rabbit (Gong et al, 2012, dog (Reich andPapoulas., 2012) pig (Monaco et al, 2012), goat (Ren et al, 2012;Costa et al, 2017), sheep (Fadel et al, 2011, equine (Wu et al, 2014) and also in wild animals such as collared peccary (Tayassu tajacu) (Pessoa et al, 2014, Argôlo-Neto et al, 2016 studies that provide essential data to understand their therapeutic potential.…”

Section: Introductionmentioning

confidence: 99%

Immunophenotyping, plasticity tests and nanotagging of stem cells derived from adipose tissue of wild rodent agouti (Dasyprocta prymnolopha)

Rocha

Leite

Silva

et al. 2019

Arq. Bras. Med. Vet. Zootec.

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There is a growing interest in the study of unspecialized mesenchymal stem cells, for there are still some discussions about their in vitro behavior. Regenerative medicine is a science undergoing improvement which develops treatments as cell therapy using somatic stem cells. In several studies, adipose tissue is presented as a source of multipotent adult cells that has several advantages over other tissue sources. This study aimed to characterize and evaluate the tagging of mesenchymal stem cells from the agoutis adipose tissue (Dasyprocta prymonolopha), with fluorescent intracytoplasmic nanocrystals. Fibroblast cells were observed, plastic adherent, with extended self-renewal, ability to form colonies, multipotency by differentiation into three lineages, population CD90 + and CD45 - expression, which issued high red fluorescence after the tagging with fluorescent nanocrystals by different paths and cryopreserved for future use. It is possible to conclude that mesenchymal stem cells from agouti adipose tissue have biological characteristics and in vitro behavior that demonstrate its potential for use in clinical tests.

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Section: Introductionmentioning

confidence: 99%

Immunophenotyping, plasticity tests and nanotagging of stem cells derived from adipose tissue of wild rodent agouti (Dasyprocta prymnolopha)

Rocha

Leite

Silva

et al. 2019

Arq. Bras. Med. Vet. Zootec.

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“…In horses, obesity has also been accompanied with impaired thermoregulation and athletic performance, altered estrous cycles, and increased inflammation [Robin et al, ]. Accordingly, several adipogenesis studies have been conducted with horse cells, especially with equine mesenchymal stem cells (eMSCs) or blood‐derived fibroblast‐like cells (ePB‐FLCs) [Vidal et al, ; Giovannini et al, ; Wu et al, ]. Although several factors, including rabbit serum [Giovannini et al, ] and B cell activating factor (BAFF) [Wu et al, ], were revealed to be helpful for regulating adipogenesis in equine cells, research is needed to determine safe and efficient ways of suppressing adipogenesis that may be utilized in the health care of companion animals and even humans.…”

Section: Discussionmentioning

confidence: 99%

Regulation of Adipogenesis Through Differential Modulation of ROS and Kinase Signaling Pathways by 3,4′‐Dihydroxyflavone Treatment

Han

Choi

Dayem

et al. 2017

J of Cellular Biochemistry

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Studies on adipogenesis may be important for regulating human and/or animal obesity, which causes several complications such as, type II diabetes, hypertension, and cardiovascular disease, thus giving rise to increased economic burden in many countries. Previous reports revealed that various flavonoids have anti-apoptotic, antioxidant, and cell differentiation-regulating activities with a number of physiological benefits, including protection from cardiovascular disease, cancers, and oxidative stress. As we found that the hydroxylation patterns of the flavonoid B ring are known to play a critical role in their function, we screened several flavonoids containing different numbers and positions of OH substitutions in B ring for their modulatory property on adipogenesis. In this study, we revealed the anti-adipogenic activity of the naturally derived flavonoid, 3,4'-dihydroxyflavone (3,4'-DHF) in murine 3T3-L1 pre-adipocytes and equine adipose-derived stromal cells (eADSCs). We found that treatment with 3,4'-dihydroxyflavone (3,4'-DHF) led to decreased expression of adipogenic markers and lipid deposition with differential modulation of ROS and kinase signaling pathways. Regulation of ROS generation through the differential modulation of ROS-regulating gene expression was revealed to have an important role in the suppression of adipogenesis and increase of osteogenesis in eADSCs following 3,4'-DHF treatment. These results suggest that the flavonoid 3,4'-DHF can be used to regulate adipogenesis in ADSCs, which has potential therapeutic application in regenerative medicine or health care for humans and many sport or companion animals. J. Cell. Biochem. 118: 1065-1077, 2017. © 2016 Wiley Periodicals, Inc.

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B-cell-activating factor deficiency attenuates high-fat diet-induced glucose intolerance by potentiating adipose tissue function

Kim

Hyun

2015

Biochemical and Biophysical Research Communications

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Equine adipose-derived stem cell (ASC) expresses BAFF and its receptors, which may be associated with the differentiation process of ASC towards adipocyte

Cited by 6 publications

References 33 publications

Immunophenotyping, plasticity tests and nanotagging of stem cells derived from adipose tissue of wild rodent agouti (Dasyprocta prymnolopha)

Immunophenotyping, plasticity tests and nanotagging of stem cells derived from adipose tissue of wild rodent agouti (Dasyprocta prymnolopha)

Regulation of Adipogenesis Through Differential Modulation of ROS and Kinase Signaling Pathways by 3,4′‐Dihydroxyflavone Treatment

B-cell-activating factor deficiency attenuates high-fat diet-induced glucose intolerance by potentiating adipose tissue function

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