Equilibrium solubility, thermodynamic modelling and Hansen solubility parameters of glimepiride (form I) in binary solvent mixtures at various temperatures

Yu, Shaoming; Gao, Xujie; Ge, Shenguang; Ma, Yuanchang; Han, Yaqi; Wang, Xingzhu; Fu, Long

doi:10.1016/j.molliq.2023.121230

Cited by 7 publications

(6 citation statements)

References 30 publications

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“…A gravimetric method was selected to measure the solubility of IHI in four binary solvents (DMF + water, DMF + ethanol, THF + water, and THF + ethanol) at temperatures ranging from 283.15 to 323.15 K at 0.1 MPa. The measurement system used here has been widely used in our previous work. ,, First, each pure solvent was accurately weighed into a beaker to prepare binary solvents with different antisolvent compositions. Then, approximately 150 mL of mixed solvents were added to a 200 mL volume glass jacketed container.…”

Section: Methodsmentioning

confidence: 99%

“…The solubility of IHI in four commonly used binary solvent mixtures of N , N -dimethylformamide (DMF) + water, DMF + ethanol, tetrahydrofuran (THF) + water, and THF + ethanol was determined. Previous studies have discussed the selection of binary solvents, such as solvents that are easily soluble in drugs as good solvents and solvents that are slightly soluble or insoluble in drugs as antisolvents. − The static gravimetric method was selected to measure the solubility of IHI. The temperature ranges from 283.15 to 323.15 K (interval 5.0 K).…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have discussed the selection of binary solvents, such as solvents that are easily soluble in drugs as good solvents and solvents that are slightly soluble or insoluble in drugs as antisolvents. 4 − 6 The static gravimetric method was selected to measure the solubility of IHI. The temperature ranges from 283.15 to 323.15 K (interval 5.0 K).…”

Section: Introductionmentioning

confidence: 99%

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Solubility Measurement and Correlation of Itraconazole Hydroxy Isobutyltriazolone in Four Kinds of Binary Solvent Mixtures with Temperature from 283.15 to 323.15 K

Dong,

Yu,

Wang

et al. 2023

ACS Omega

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The solubility of itraconazole hydroxy isobutyltriazolone (IHI) in four commonly used binary solvent mixtures of N,N-dimethylformamide (DMF) + water, DMF + ethanol, tetrahydrofuran (THF) + water, and THF + ethanol was determined with gravimetric method at temperatures ranging from 283.15 to 323.15 K under atmospheric pressure. The solubility of IHI in all selected solvents increases with the increase of temperature. The maximum solubility of IHI exists in the solvent of DMF + ethanol (0.06523 mol·mol–1, x 2 0 = 0.7, T = 323.15 K), while the minimum solubility exists in DMF + water (0.0003723 mol·mol–1, x 2 0 = 0.3, T = 283.15 K). There is a co-solvency phenomenon in the mixed solvents of DMF+ ethanol, THF + water, and THF + ethanol. Four thermodynamic models, including the modified Apelblat model, the Yaws model, the Sun model, and the modified Jouyban–Acree model, were selected to fit the solubility data of IHI. All the RAD values are less than 0.0484, and RMSD values are not more than 0.001319. The Yaws model and the modified Apelblat model fit the solubility data of IHI better than the other two models. All the selected four models can fit the solubility data of IHI well.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Solubility Measurement and Correlation of Itraconazole Hydroxy Isobutyltriazolone in Four Kinds of Binary Solvent Mixtures with Temperature from 283.15 to 323.15 K

Dong,

Yu,

Wang

et al. 2023

ACS Omega

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“…J i is the model parameter. When combined with the modified Apelblat model, the modified Jouyban–Acree model − can be obtained and expressed as follows ln nobreak0em0.25em⁡ x 1 = B 1 + B 2 T + B 3 nobreak0em0.1em⁡ ln nobreak0em0.25em⁡ T + B 4 x 2 0 + B 5 x 2 0 T + B 6 ( x 2 0 ) 2 T + B 7 ( x 2 0 ) 3 T + B 8 ( x 2 0 ) 4 T + B x 2 0 nobreak0em0.1em⁡ ln nobreak0em0.25em⁡ T where B 1 to B 9 are the final model parameters.…”

Section: Theoretical Modelsmentioning

confidence: 99%

“…J i is the model parameter. When combined with the modified Apelblat model, the modified Jouyban–Acree model − can be obtained and expressed as follows where B 1 to B 9 are the final model parameters.…”

Section: Theoretical Modelsmentioning

confidence: 99%

Solubility Determination, Modeling, and Thermodynamic Analysis of 3-Aminophenol in Ten Monosolvents and Three Binary Mixed Solvents

Wu,

Xue,

Wang

et al. 2024

J. Chem. Eng. Data

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The solubilities of 3-aminophenol in monosolvents (ethyl acetate, isopropyl acetate, n-butyl acetate, amyl acetate, 1,2-dichloroethane, trichloromethane, benzene, 1,4-dioxane, tetrahydrofuran, and acetonitrile) and binary solvent mixtures (1,4-dioxane + water, tetrahydrofuran + water, and acetonitrile + water) were determined by a static gravimetric method at temperatures ranging from 283.15 to 328.15 K under atmospheric pressure. The solubility of 3-aminophenol in all solvent systems is positively correlated with temperature. In monosolvents, the solubility order of 3-aminophenol was as follows: THF > 1,4-dioxane > acetonitrile > ethyl acetate > isopropyl acetate > n-butyl acetate > amyl acetate > 1,2-dichloroethane > trichloromethane > benzene. The maximum solubility value occurred in 1,4-dioxane (x 1 = 0.3700 mol·mol–1, T = 328.15 K), and the minimum solubility value occurred in benzene (x 1 = 0.0005505 mol·mol–1, T = 288.15 K). In general, the solubility of 3-aminophenol in 1,4-dioxane + water and THF + water is greater than that in acetonitrile + water. There is a cosolvency phenomenon of 3-aminophenol in the solvents of 1,4-dioxane + water and acetonitrile + water. The experimental solubility data were correlated by the modified Apelblat model, the Yaws model, the λh model, the Sun model, the modified Jouyban–Acree model, and the Wilson model. The modified Apelblat model best fitted the experimental data among all of the selected models in monosolvents (with relative average deviation (RAD) and root-mean-square deviation (RMSD) less than 0.0156 and 0.001212, respectively) and binary solvent mixtures (with RAD and RMSD less than 0.0102 and 0.001408, respectively). Based on the experimental data of the solubility of 3-aminophenol in mono and binary solvents, the Wilson model was used to calculate the dissolution properties (Δdis H, Δdis S, and Δdis G). The results indicate that the dissolution process of 3-aminophenol is endothermic, entropy-increasing, and spontaneous. All of the selected models for both mono and binary solvents provide satisfactory correlation results.

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Equilibrium solubility, solvent effect, equation correlation, and thermodynamic properties of cyclododecanone in twelve organic solvents

Zhao,

Zhang,

Liu

et al. 2023

Journal of Molecular Liquids

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Equilibrium solubility, thermodynamic modelling and Hansen solubility parameters of glimepiride (form I) in binary solvent mixtures at various temperatures

Cited by 7 publications

References 30 publications

Solubility Measurement and Correlation of Itraconazole Hydroxy Isobutyltriazolone in Four Kinds of Binary Solvent Mixtures with Temperature from 283.15 to 323.15 K

Solubility Measurement and Correlation of Itraconazole Hydroxy Isobutyltriazolone in Four Kinds of Binary Solvent Mixtures with Temperature from 283.15 to 323.15 K

Solubility Determination, Modeling, and Thermodynamic Analysis of 3-Aminophenol in Ten Monosolvents and Three Binary Mixed Solvents

Equilibrium solubility, solvent effect, equation correlation, and thermodynamic properties of cyclododecanone in twelve organic solvents

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