Equilibrium solubility, preferential solvation and apparent specific volume of sucrose in some {cosolvent (1) + water (2)} mixtures at 298.2 K

Apparent Specific Volumes of Sucrose in Different Aqueous Cosolvent Mixtures at 298.2 K

“…It is important to note that reported value at saturation in neat water is 0.632 cm 3 .g -1 (equilibrium solubility is w3 = 0.6879) 4,5 which is just coincident with that obtained in the mixture of w3 = 0.6252 (Table 1). Table 2 summarizes the sucrose behavior in aqueous cosolvent mixtures of ethanol, propylene glycol and glycerol, which are the non-polymeric cosolvents more used in pharmaceutics of liquid medicines.…”

“…2,3 For this reason, some physicochemical properties of this natural excipient in aqueous cosolvent mixtures, like equilibrium solubility and volumetric contributions, are very important from a practical point of view to facilitate the duties of pharmaceutical scientists during all the stages related to dosage forms design and development. 4,5 Although sucrose as additive has been used for centuries in several industries, and some reports about its apparent specific and/or molar volume in water or cosolvent mixtures have been reported in the literature, [4][5][6][7][8][9][10] the information about its volumetric physicochemical behavior in mixed aqueous solutions is still far to be complete. 4,5 Particularly, up to the best of our knowledge, no apparent specific volumes of sucrose as a function of sucrose concentration in aqueous cosolvent mixtures have been reported in the literature.…”

“…In this way, only apparent specific volumes of sucrose at saturation in the most common aqueous cosolvent mixtures have been reported. 4,5 It is noteworthy that the volumes of components in solution are not additive owing the different intermolecular interactions and/or differences in molar volumes. Therefore, the real volumetric contribution of each component is expressed by the partial molar or specific volumes, which depend on temperature and mixtures compositions, and thus, normally are not known for the vast majority of compounds.…”

“…11,12 Thus, this research expands the information reported previously with this pharmaceutical sweetener agent in several {cosolvent (1) + water (2)} mixtures. 4,5 Sucrose (IUPAC name: (2R,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)ox -olan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol; CAS number: 57-50-1; molar mass: 342.30 g.mol -1 ; 13 mass fraction purity: 0.995; Ingenio Riopaila, Colombia), ethanol (EtOH, CAS number: 64-17-5; molar mass: 46.07 g.mol -1 ; 13 mass fraction purity: 0.995; Merck, Germany), propylene glycol (PG, CAS number: 57-55-6; molar mass: 76.10 g.mol -1 ; 13 mass fraction purity: 0.992; Dow Chemical Co., USA), glycerol (G, CAS number: 56-81-5; molar mass: 92.09 g.mol -1 ; 13 mass fraction purity: 0.990; Dow Chemical Co., USA), polyethylene glycol 200 (PEG 200; CAS number: 25322-68-3; mean molar mass: 200 g.mol -1 ; 13 mass fraction purity: 0.990; Dow Chemical Co., USA), polyethylene glycol 400 (PEG 400; CAS number: 25322-68-3; mean molar mass: 400 g.mol -1 ; 13 mass fraction purity: 0.992; Dow Chemical Co., USA), and distilled water with conductivity < 2 μS.cm -1 , were used in this research. Molecular sieve (numbers 3 and 4, Merck, Germany) was also used.…”

“…Sucrose concentrations were chosen based on the solubility exhibited by this compound in the respective aqueous cosolvent mixtures to cover a wide range of compositions. 4,5 Moreover, these are the concentrations commonly used to design liquid dosage forms mainly intended for the oral administration route. 2,3…”