Equilibrium solubility determination, solvent effect and preferential solvation of amoxicillin in aqueous co-solvent mixtures of N,N-dimethylformamide, isopropanol, N-methyl pyrrolidone and ethylene glycol

New Screening Protocol for Effective Green Solvents Selection of Benzamide, Salicylamide and Ethenzamide

“…Due to the absence of corresponding experimental data for benzamide, these two solvents were chosen as the first choice for further experimental investigations and to expand the pool of available solubility data. These two solvents are characterized by high efficiency in dissolving many solids, including active pharmaceutical ingredients [ 18 , 40 , 45 , 47 , 49 , 111 , 112 ]. Their solubilizing potential can be interpreted in terms of solute-solvent affinity and in the particular case of benzamide the expected structures and corresponding energetics, determined theoretically, are documented in Figure 1 .…”

“…Noteworthy, although water is often considered an anti-solvent compared to organic solvents, in some cases, it can enhance the solubility, as a result of a significant co-solvation effect. Such synergism was frequently observed in many aqueous binary mixtures as for example for sulfamethizole in 1,4-dioxane [ 40 , 44 ] or acetonitrile binary mixtures [ 40 ], sulfanilamide in ethanol, acetonitrile and 1,4-dioxane [ 45 , 46 ], nicotinamide in DMSO and acetonitrile [ 18 ], phenacetin in 1,4-dioxane [ 47 , 48 ], amoxicillin in DMF-water [ 49 ] and theophylline in aqueous DMF, DMSO, 1,4-dioxane, 1-propanol and 1-butanol [ 33 , 50 , 51 ].…”

Solubility Measurement, Preferential Solvation, and Solvent Effect of 3,5-Dinitrosalicylic Acid in Several Binary Aqueous Blends

“…The Jouyban−Acree model could be expressed as eq 1. 11,[14][15][16][17]28,36,37 It is able to provide precise description for the dependence of solute solubility on both solvent composition and temperature for binary and ternary mixtures.…”

“…Eq 5 presents the universal form of the KAT-LSER model used for the description of solvent effect upon solute solubility variation. [14][15][16][17]27,43,44…”

“…3,5-Dinitrosalicylic Acid Solubility Measurement. Construction of equilibrium systems for 3,5-dinitrosalicylic acid in various solutions was made by means of the commonly used method of shake-fl ask saturation, 14,15,17,27,47,48 wherein the consistency was validated using the solubility of solid solute of benzoic acid in neat toluene. 47 All experiments were done at an ambient pressure of 101.2 kPa.…”