Equilibrium solubilities of ammonium benzoate, benzamide and their mixture in supercritical carbon dioxide

Jin, Jiye; Wang, Yübo; Wu, Hao; Li, Jialin; Zhang, Zeting

doi:10.1016/j.fluid.2012.05.031

Cited by 13 publications

(8 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As the main advantage of the analytic-flow method, the sampling in this method is faster and easier than the sampling in other methods, and it does not disturb the equilibrium state. This method was used by Shimoyama et al (2008) to investigate phase equilibria; it is applied by many other researchers (Suzuki et al, 1991;, Xing et al, 2003;Ferri et al, 2004;Ghaziaskar and Kaboudvand, 2008;Tang et al, 2011;Jin et al, 2012;Li et al, 2013;Danlami et al, 2015;and Wu et al, 2016) to examine solubility.…”

Section: Analytic-flow Methodsmentioning

confidence: 99%

Study of Solubility in Supercritical Fluids: Thermodynamic Concepts and Measurement Methods - A Review

Rad

Karimi-Sabet

Varaminian

2019

Braz. J. Chem. Eng.

View full text Add to dashboard Cite

Due to the importance of supercritical fluid technology (SFT) in different industries, it has been the subject of intense research in recent decades. Solubility is a key concept in SFT. In fact, obtaining knowledge about the theoretical concepts of solubility and related experimental measurement methods can be useful in developing and improving the quality of research in this field. This study reviews the fundamental knowledge of solubility in supercritical fluids and investigates the significant topics in this field, including high-pressure phase behavior, experimental measurement methods, modeling, and molecular simulation of solubility.

show abstract

Section: Analytic-flow Methodsmentioning

confidence: 99%

Study of Solubility in Supercritical Fluids: Thermodynamic Concepts and Measurement Methods - A Review

Rad

Karimi-Sabet

Varaminian

2019

Braz. J. Chem. Eng.

View full text Add to dashboard Cite

show abstract

“…In that context, the supercritical fluids (SF) are being recognized as potential substitutes for conventional organic solvents for obtaining natural extracts. In this regard, numerous investigations have found that the SF are capable of providing natural extracts with a great bioactivity and quality, excluding any toxicity and responding to safety standards established for food, cosmetic and pharmaceutical industries [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…and 0.01 MPa) and lyophilized (233.15 K and 0.013 MPa). Equation(1) was used to determine the extraction yield. It expresses the results as a percentage of lyophilized extract as gram per gram of cocoa husk dry basis (g LE/g db.).…”

mentioning

confidence: 99%

Supercritical extraction of bioactive compounds from Cocoa husk: study of the main parameters

Pico-Hernández

Jaimes-Estévez

López-Giraldo

et al. 2019

Rev.Fac.Ing.Univ.Antioquia

View full text Add to dashboard Cite

Cocoa is a product of natural origin rich in polyphenols, mainly procyanidins and flavan-3-ols, which has a high antioxidant power. Its regular consumption brings positive health effects. The objective of the present study was to evaluate the effects of diameter of particle, extraction time, temperature, pressure and ethanol concentration in the supercritical fluid extraction (SFE) of bioactive compounds from cocoa husk. This work was developed in two stages. The first stage was aimed to study the impact of the particle size and extraction time. Extractions were carried out under constant conditions. Once particle size and extraction time were defined, it gave way to the second stage, where the effect of three levels of temperature (308.15, 313.15 and 318.15 K), pressure (10, 15 and 20 MPa) and concentration of ethanol (2, 11, and 20% ethanol) were evaluated. The results of this study suggest that particle sizes less than 0.26mm and extraction times exceeding 147min could increase the total polyphenol content (TPC). Finally, a multivariate statistical analysis was developed, showing that the most favorable conditions for obtaining extracts rich in polyphenols corresponded to 308.15K, 20MPa and 20% ethanol, under which the TPC was 35.11(±1.57)EAGmg/LEg, a total flavan-3-oles content (TFC) of 12.89 (±0.51)EEPmg/gLE and total carotenoids content (TCC) of 64.35(±1.54)EBC mg/gLE. The results obtained suggest that SFE favors the extraction of apolar compounds (carotenoids) from cocoa husk. Likewise, for the optimal extraction point, husk cocoa showed antioxidant capacity of 489.58μmol ET/LEg.

show abstract

“…Below the crossover region the solvent density (solvent power) effect is dominant so the solute is more soluble at low temperature and the solubility of ATRA decreases when temperature increases while above the crossover region the solute vapor pressure prevails over the solvent density and the solubility increases with temperature. This phenomenon is known as retrograde solubility behavior and was already reported in the literature for other solute-scCO 2 systems [31,32,[45][46][47][48]. The solubility data measured for ATRA was compared with that previously reported in the literature for retinol [26] to conclude about the influence of the substitution of the terminal carboxyl functional group in retinoic acid by the hydroxyl functional group in retinol on the solubility of each molecule in scCO 2 (the chemical structure of both molecules is given in Fig.…”

Section: Tablementioning

confidence: 61%

Solubility of all-trans retinoic acid in supercritical carbon dioxide

Rosa

Marceneiro

Braga

et al. 2015

The Journal of Supercritical Fluids

View full text Add to dashboard Cite

All-trans retinoic acid (ATRA) is a derivative of retinol (or vitamin A) presenting similar benefits but considerable lower adverse toxicity, mainly in cases of high or long-term therapeutic doses. ATRA showed to be effective in the treatment and/or chemoprevention of several epithelial and hematological malignancies and diverse dermatological and eye diseases however, its low solubility in aqueous media and photosensitivity hinder its wider usage by the conventional administration methods. Supercritical fluids technologies are being widely used to enhance the in vivo bioactivity of this type of drugs both by improving their dissolution rate (using particle size reduction processes) and/or by controlling their release into the media after incorporation into solid polymeric/inorganic matrices (using supercritical impregnation/foaming processes). In both cases the solubility of the drug in the supercritical fluid (usually scCO 2) is required for process optimization purposes. Therefore, in this work the solubility of ATRA in scCO 2 was measured at different isotherms (308.2, 318.2 and 328.2 K) and pressures that ranged from 10 up to 30 MPa using a static analytical method. Solubility data were correlated using three commonly used density-based models, namely the Bartle, Chrastil and Méndez-Santiago-Teja models. The solubility of ATRA in scCO 2 was found to be between 1.52 × 10 −6 and 1.84 × 10 −5 in terms of ATRA mole fraction and between 7.50 × 10 −3 and 1.07 × 10 −1 in terms of amount of solid solute per unit of volume of scCO 2. Fairly good correlation agreement was obtained with all the applied models being the lowest deviations obtained with the Chrastil model. ATRA particles obtained after scCO 2 processing (dissolution in scCO 2 followed by re-precipitation) were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared (FTIR) and in vitro dissolution studies. The results showed that the processed particles maintained their chemical structure and presented enhanced dissolution in aqueous media (PBS:ethanol, 80:20, v/v) when compared with commercial (non-processed) ATRA.

show abstract

Equilibrium solubilities of ammonium benzoate, benzamide and their mixture in supercritical carbon dioxide

Cited by 13 publications

References 27 publications

Study of Solubility in Supercritical Fluids: Thermodynamic Concepts and Measurement Methods - A Review

Study of Solubility in Supercritical Fluids: Thermodynamic Concepts and Measurement Methods - A Review

Supercritical extraction of bioactive compounds from Cocoa husk: study of the main parameters

Solubility of all-trans retinoic acid in supercritical carbon dioxide

Contact Info

Product

Resources

About