Equilibrium sampling through membrane based on a single hollow fibre for determination of drug–protein binding and free drug concentration in plasma

Trtić-Petrović, Tatjana; Liu, Jingfu; Jönsson, Jan Åke

doi:10.1016/j.jchromb.2005.08.020

Cited by 21 publications

(18 citation statements)

References 29 publications

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“…All experiments were conducted in triplicate, and the average value and relative standard deviations were presented as the results. Similar experimental setup was described in more details in [19,20].…”

Section: Procedures Of Slme and Mmlle In A Single Hollow Fibrementioning

confidence: 99%

“…SLME in a single hollow fibre has been applied to investigate the equilibrium extraction of organic pollutants from wastewaters [19] and for the determination of drug-protein binding [20]. In addition to the well-known major benefits of membrane extraction such as large interfacial area per unit volume, low consumption of organic solvents, good opportunity for process automation, etc., SLME in a single hollow fibre has several added advantages such as being easy to handle, no need for a special device to avoid accidental release of radioactive material, and a sample volume as low as 1 cm 3 .…”

Section: Introductionmentioning

confidence: 99%

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Extraction of lutetium(III) from aqueous solutions by employing a single fibre‐supported liquid membrane

Trtić-Petrović¹,

Kumrić²,

Đorđević³

et al. 2010

J of Separation Science

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Transport behaviour of Lu(III) across a polypropylene hollow fibre-supported liquid membrane containing di(2-ethylhexyl)phosphoric acid (DEHPA) in dihexyl ether as a carrier has been studied. The donor phase was LuCl(3) in the buffer solution consisting of 0.2 M sodium acetate at pH 2.5-5.0. A miniaturised system with a single hollow fibre has been operated in a batch mode. The concentration of Lu(III) was determined by indirect voltammetric method using Zn-EDTA complex. The effect of pH and volume of the donor phase, DEHPA concentration in the organic (liquid membrane) phase, the time of extraction and the content of the acceptor phase on the Lu(III) extraction and stripping behaviour was investigated. The results were discussed in terms of the pertraction and removal efficiency, the memory effect and the mean flux of Lu(III). The optimal conditions for the removal of (177)Lu(III) from labelled (177)Lu-radiopharmaceuticals were discussed and identified. The removal efficiency of Lu(III) greater than 99% was achieved at pH of the donor phase between 3.5 and 5.0 using DEHPA concentration in the organic phase of 0.47 M and the ratio of the donor to the acceptor phase of 182.

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Section: Procedures Of Slme and Mmlle In A Single Hollow Fibrementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Extraction of lutetium(III) from aqueous solutions by employing a single fibre‐supported liquid membrane

Trtić-Petrović¹,

Kumrić²,

Đorđević³

et al. 2010

J of Separation Science

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“…The theory of determining free drug concentration and level of DPB by applying ESTM was presented earlier [16,17], and below is only given a description of the theory.…”

Section: Estm Determination Of Free Drug Concentrationmentioning

confidence: 99%

“…Membrane extraction techniques have been used for quantifying total drug extraction from plasma [15] and for evaluating the extent of DPB in plasma samples [16,17] by using the equilibrium sampling through membrane (ESTM) technique [18]. Some of the demerits of the aforementioned non-membranebased techniques can be seen as that, firstly, the universality of fluorescence spectroscopy is questionable because tryptophan residues reflect only a portion of the potential binding sites to both AGP and HSA.…”

Section: Introductionmentioning

confidence: 99%

Characterization of drug–protein binding process by employing equilibrium sampling through hollow-fiber supported liquid membrane and Bjerrum and Scatchard plots

Barri

Trtić-Petrović

Karlsson

et al. 2008

Journal of Pharmaceutical and Biomedical Analysis

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“…As a result, the HF-LLPME provides a convenient and efficient means of separating free drug from protein-bound drug in solution. HF-LLPME method has recently been used to assay the DPB interaction [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Rapid and Simultaneous Study on Drug–Protein Binding of Four Furocoumarins by Hollow Fiber Liquid Phase Microextraction

Zhang

Bai

2011

Chromatographia

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Hollow fiber liquid-liquid phase microextraction followed by high-performance liquid chromatography was employed to research the binding of four furocoumarin compounds (psoralen, oxypeucedanin, imperatorin and isoimperatorin) to bovine serum albumin. The results reveal that the percent of drug-protein binding did not rely on the furocoumarins and protein concentrations, and four furocoumarins scarcely competed for protein binding sites. The protein-binding percents of psoralen, oxypeucedanin, imperatorin and isoimperatorin were 55.1 ± 4.5, 14.4 ± 2.4, 44.1 ± 6.7, and 41.3 ± 3.8%, respectively, the numbers of binding sites were 1.2, 1.6, 0.6 and 0.3, and the binding constants were 1,801, 212, 937 and 4,025 L mol -1 , respectively. The proposed new approach is simple, rapid, and effective for the study of the interaction between protein and furocoumarin compounds which is either individual or coexistent with the similar ones.

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Equilibrium sampling through membrane based on a single hollow fibre for determination of drug–protein binding and free drug concentration in plasma

Cited by 21 publications

References 29 publications

Extraction of lutetium(III) from aqueous solutions by employing a single fibre‐supported liquid membrane

Extraction of lutetium(III) from aqueous solutions by employing a single fibre‐supported liquid membrane

Characterization of drug–protein binding process by employing equilibrium sampling through hollow-fiber supported liquid membrane and Bjerrum and Scatchard plots

Rapid and Simultaneous Study on Drug–Protein Binding of Four Furocoumarins by Hollow Fiber Liquid Phase Microextraction

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