Equilibrium Reaction of Pyrazolodiazepinones in Aqueous Solution

Reversible ring-opening reactions of nimetazepam and nitrazepam in acidic media at body temperature

“…As an antiviral drug, distamycin A inhibits the multiplication of DNA viruses and certain retroviruses (3)(4)(5)(6)(7). As an antiviral drug, distamycin A inhibits the multiplication of DNA viruses and certain retroviruses (3)(4)(5)(6)(7).…”

Polarographic behaviour and degradation studies of triazolam

“…It appears from the hterature [3][4][5][6][7][8][9][10][11][12][21][22][23][24] that this reaction is due principally to the fact that thèse molécules have an oxygen doubly bonded to the Cj (benzodiazepinones), compounds without the double bond being stable [23,24]. This double bond, modifying the conformation of the central heterocycle, favours hydrolysis.…”

“…The purpos e of this work is to d e scrib e th e e l e ctroch e mical b e haviour of triazolam and to study its hydrolysis re action in acidic média. Se ve ral b e nzodiaz e pin e s prése nt similar re actions which may be re late d to the structure [3][4][5][6][7][8][9][10][11][12] and can be use d to déte rmine the ir me tabolite s in blood and urine [13].…”