Equilibrium adsorption isotherm and controlled release of antibiotic drug chloroamphenicol from poly(2‐vinyl pyridine/acrylic acid) hydrogels prepared by gamma radiation

Abstract

High water sorption of 2-vinyl pyridine (2-VP)/acrylic acid (AAc) hydrogel were prepared by freeradical polymerization in aqueous solution of 2-VP with AAc as comonomer. The amount of ionic monomer (AAc), the irradiation dose of prepared hydrogel, the pH, and the concentration of drug play an important factor on loading, adsorption, and releasing of water-soluble chloroamphenicol drug. As a result of dynamic swilling tests, the effect of relative content of AAc on the swelling showed that it allowed a non-Fickian type of water diffusion. The adsorption of the drug onto (2-VP/AAc) hydrogels was studied by Freundlish adsorption isotherm. The drug concentrations showed an influence on the adsorption of drug which increased with increasing AAc content. From Freundlish adsorption isotherm, the empirical constants, k and n, can be evaluated and showed the ability of hydrogel to be loaded by the drug and the affinity of the drug to be uptake onto the hydrogel respectively. FTIR, TGA, and SEM techniques were used to study the characterization of hydrogel (2-VP/AAc). Additionally, the release of the drug loaded from hydrogel discs was studied microbiologically to show that hydrophilic structure of the hydrogel has an antimicrobial effect as a dehydration of cytoplasm and unbalance of the cell wall functions.

Adsorption of cefotaxime sodium salt on polymer coated ion exchange resin microparticles: Kinetics, equilibrium and thermodynamic studies

“…It can be seen that a good fitting of Freundlich model to experimental data is achieved. Similar behavior was observed in adsorption process of acetaminophen, 17␣-ethyl estradiol, nalidixic acid, norfloxacin (Lorphensri et al, 2006) and chloramphenicol (Maziad, El-Aal, & El-Kelesh, 2009) on various adsorbents. (Dubinin, Zaverina, & Radushkevich, 1947).…”

Antimicrobial hydrogels formed by crosslinking polyallylamine with aldaric acid derivatives

“…Polymers and hydrogels that contain silver nanoparticles1–7 or that release iodine,8 proteins,9, 10 or antibacterial11–17 or antifungal18–20 drugs are well known. However, polymers21–29 and hydrogels30–35 that are inherently antimicrobial are relatively scarce, even though they have a number of advantages over small‐molecule biocides and polymers that release them.…”

Synthesis and characterization of polysaccharide-based antimicrobial materials

“…15 Host defenses are often not capable of preventing further colonization if bacterial adhesion occurs before tissue integration at the implant. 18,65 Antimicrobial hydrogels based on drug-release strategy have been very popular in recent years, and these may be designed to release antibiotics, [66][67][68][69] The proteolysis of AMPs is not a disadvantage but beneficial for implants that need biodegradable antimicrobial surfaces. The first 6 h after implantation is the "decisive period" to prevent adhesion of microbes on it, which is critical for long-term success of an implant.…”