Equilibria in the aqueous system of cobalt(II) based on 2-picolinehydroxamic acid and N-(2-hydroxybenzyl)phenylalanine and its ability to inhibit the propagation of cancer cells

Halogenated non-innocent vanadium(v) Schiff base complexes: chemical and anti-proliferative properties

“…Metal complexes incorporating Schiff bases have shown and continue to be developed for a wide variety of applications, from catalysis 1,2 to bioactive compounds with typical metal ions used for the bioactive complexes spanning Cu( ii ), Co( ii ), Fe( ii ), and Ni( ii ). 3–6 Non-innocent Schiff base vanadium-catecholates (V-catecholates) have interesting electronic properties with the potential for redox taking place not only on the metal center but also on the ligand. 3,7–9 The subclass of non-innocent Schiff base V-catecholates have recently been discovered to have desirable pharmaceutical properties 3–6,8–16 which has expanded the knowledge on anti-diabetic and anti-cancer properties of vanadium complexes.…”

“…3–6 Non-innocent Schiff base vanadium-catecholates (V-catecholates) have interesting electronic properties with the potential for redox taking place not only on the metal center but also on the ligand. 3,7–9 The subclass of non-innocent Schiff base V-catecholates have recently been discovered to have desirable pharmaceutical properties 3–6,8–16 which has expanded the knowledge on anti-diabetic and anti-cancer properties of vanadium complexes. 3,4,6,8–18 The reported antiproliferative properties of the class of non-innocent Schiff base V-catecholates were reported to surpass the efficacy of cisplatin in human chondrosarcoma (SW1353) bone cells, T98G glioblastoma cells, aggressive mesenchymal-like MDA-MB-231 cells, A549 (lung) and PANC-1 (pancreas) cancer cell lines, and HFF-1 (human foreskin fibroblasts) normal cells.…”

“…3,7–9 The subclass of non-innocent Schiff base V-catecholates have recently been discovered to have desirable pharmaceutical properties 3–6,8–16 which has expanded the knowledge on anti-diabetic and anti-cancer properties of vanadium complexes. 3,4,6,8–18 The reported antiproliferative properties of the class of non-innocent Schiff base V-catecholates were reported to surpass the efficacy of cisplatin in human chondrosarcoma (SW1353) bone cells, T98G glioblastoma cells, aggressive mesenchymal-like MDA-MB-231 cells, A549 (lung) and PANC-1 (pancreas) cancer cell lines, and HFF-1 (human foreskin fibroblasts) normal cells. The efficacy of these molecules elicited proposals for intratumoral injections 19 as a viable treatment because their potential properties enable intact complexes for cellular uptake which then hydrolyze over time into much less toxic components.…”