Abstract:Electrospray ionization
mass spectrometry (ESI-MS) is widely used
in drug development, therapeutic drug monitoring, and other fields.
However, unstable mass spectral signals, especially during the initial
stages of instrument operation, plague analysts. Generally, in quantitative
experiments, the stability of response can be achieved by running
the analytical system for some time. However, the equilibration time
required for the responses of different compounds to stabilize has
been elusive. To investigate the… Show more
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