Equid herpesvirus 5-associated dermatitis in a horse—Resembling herpes-associated erythema multiforme

Equine multinodular pulmonary fibrosis in three horses in Australia

“…A plasma viraemia has not been identified and dissemination of EHV‐5 through the host is currently thought to be via B‐lymphocytes . EHV‐5 has a documented trophism for the lungs and skin, with potential sites of latency that include B‐lymphocytes, mononuclear cells, macrophages dendritic cells and the conjunctivae . Recently, EHV‐5 in horses has been associated with EMPF, lymphoma and dermatitis .…”

Dermatopathology – the link between ancillary techniques and clinical lesions

“…A close relationship of human and equine Molluscum contagiosum virus has been suggested based on the identification of the virus in equine lesions using two human Bam HI‐restricted fragments of human M. contagiosum type I DNA . The pathological effect of equine Herpesvirus‐5 on keratinocytes has been documented where the virus in keratinocytes exhibited cytotoxic effects . As in many other species, PCR identifies papilloma virus in normal skin and BPV has been claimed to be associated with various non‐neoplastic skin lesions in horses .…”

“…69 The pathological effect of equine Herpesvirus-5 on keratinocytes has been documented where the virus in keratinocytes exhibited cytotoxic effects. 70 As in many other species, PCR identifies papilloma virus in normal skin and BPV has been claimed to be associated with various non-neoplastic skin lesions in horses. [71][72][73] However, ISH offered proof that the presence of BPV-1 and BPV-2 are very restricted to lesions of equine sarcoid, whereas adjacent keratinocytes and dermal tissues were negative ( Figure 5).…”

A retrospective review of hyperaesthetic leucotrichia in horses in the USA

“…[14][15][16][17] Equine herpesvirus-5 has been identified in biopsies from one horse with lesions consistent with EM. 18 However, the presence of intranuclear inclusion bodies is more consistent with an active cutaneous herpes infection rather than EM. 19 The goals of this retrospective study were to determine the breed predisposition for HL and to describe the typical clinical signs, any predisposing causes and the course of the disease in horses with a compatible history.…”

“…Herpesvirus can be identified by PCR in many of these cases . Equine herpesvirus‐5 has been identified in biopsies from one horse with lesions consistent with EM . However, the presence of intranuclear inclusion bodies is more consistent with an active cutaneous herpes infection rather than EM …”