1983
DOI: 10.1002/ijc.2910320307
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Epstein‐Barr virus specific T‐cell response in nasopharyngeal carcinoma patients

Abstract: There is a substantial body of evidence suggesting an association between Epstein-Barr virus (EBV) and undifferentiated nasopharyngeal carcinoma (NPC). The present study has compared a group of NPC patients (newly diagnosed and long-term survivors) and controls for EBV-specific T-cell immunity using the regression of transformation assay. Newly diagnosed patients (17 tested) when compared with either long-term survivors (20 tested) or controls (30 tested) showed a significant impairment in virus-specific T-cel… Show more

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Cited by 49 publications
(31 citation statements)
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“…18 -20 These features do not appear to be directly related to the tumor, however, since they persist among survivors after successful treatment of the cancer. NPC patients also show an impaired T-cell response 21 and sustain lower levels of EBV-specific CTL. 9 Unlike the general immune suppression and vigorous EBV antibody response, level of EBV CTL changed with disease progression and was restored to normal among survivors after successful treatment.…”
Section: Discussionmentioning
confidence: 99%
“…18 -20 These features do not appear to be directly related to the tumor, however, since they persist among survivors after successful treatment of the cancer. NPC patients also show an impaired T-cell response 21 and sustain lower levels of EBV-specific CTL. 9 Unlike the general immune suppression and vigorous EBV antibody response, level of EBV CTL changed with disease progression and was restored to normal among survivors after successful treatment.…”
Section: Discussionmentioning
confidence: 99%
“…It is possible that the elevated anti-LMP response in BL, NPC and RA is a consequence of impaired EBV-specific cytotoxic T cell immunity, which controls the numbers of EBV-infected normal B cells (Gaston et al, 1985;Moss et al, 1983;Whittle et al, 1984). In this regard it is interesting that the healthy donor ST who showed an exceptionally strong anti-LMP response in the IPIB assay in the present study (Table 3), has a deficient EBV-specific cytotoxic T cell response (Bejarano et al, 1987).…”
Section: Discussionmentioning
confidence: 99%
“…NPC patients possessed CTL precursors specific for EBV-LMP2 and EBV-specific T cell responses were detectable in patients, albeit at lower levels than in healthy controls (26,27). The point was whether they included responses to those viral proteins expressed in the tumor.…”
Section: Introductionmentioning
confidence: 99%