Epstein‐Barr virus specific T‐cell response in nasopharyngeal carcinoma patients

Moss, Denis J.; Chan, Soh Ha; Burrows, Scott R.; Chew, Thean S; Kane, R. G.; Staples, J.; Kunaratnam, N.

doi:10.1002/ijc.2910320307

Cited by 49 publications

(31 citation statements)

References 28 publications

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“…18 -20 These features do not appear to be directly related to the tumor, however, since they persist among survivors after successful treatment of the cancer. NPC patients also show an impaired T-cell response 21 and sustain lower levels of EBV-specific CTL. 9 Unlike the general immune suppression and vigorous EBV antibody response, level of EBV CTL changed with disease progression and was restored to normal among survivors after successful treatment.…”

Section: Discussionmentioning

confidence: 99%

Peripheral γδ T‐cell deficit in nasopharyngeal carcinoma

Zheng

Chua

et al. 2002

Intl Journal of Cancer

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Previous studies identified CD56؉ and CD56 ؊ subsets of peripheral ␥␦ T cells from healthy donors. Both subsets responded to stimulation by a myeloma cell line, XG-7 and undergo vigorous ex vivo expansion in the presence of exogenous IL-2. They are cytotoxic for different tumor targets including nasopharyngeal carcinoma, but they differ from one another in that the CD56 ؊ subset has an additional growth requirement for IL-7 and exhibited greater cytotoxicity against nasopharyngeal carcinoma (NPC) targets. These immune cells were further shown to retard tumor growth in a nude mice NPC model. To assess if these immune cells might contribute to host defense against NPC, we compared ␥␦ T-cell status of NPC patients with healthy donors and survivors who had been in clinical remission of the cancer. It was found that peripheral ␥␦ T cells of patients were impaired in their response to the stimulatory effects of XG-7 and exhibited weak or essentially no cytotoxicity for the NPC targets. The deficits were present in early and advanced stages of the cancer but were restored among survivors after successful treatment of the cancer. These findings support a role for peripheral ␥␦ T cells in host defense against NPC. It was noted that these immune cells comprise less than 5% of peripheral blood monocytic cells and hence it was not surprising that this component of host defense was breached early in the development of the cancer. © 2002 Wiley-Liss, Inc. Key words: ␥␦ T cells; immune deficit; NPC; tumor immunityT-cell immunity is the principal component of host defense against chronic infection and tumors. The effector arms are mainly composed of 2 subpopulations of cytotoxic T lymphocytes (CTLs) bearing TCR-␣␤ or -␥␦ chains. The ␣␤ CTLs recognize processed antigenic peptides bound to the major histocompatibility complex (MHC) and hence their effector functions are restricted to targets that express identical or related MHC. The ␥␦ T cells effect non-MHC-restricted killing. Although ␥␦ T cells constitute only 1-10% of circulating T cells, recent studies have demonstrated that this minor subpopulation of T cells plays a more important role in the host immune defense than their relatively sparse numbers might suggest. 1,2 These 2 subpopulations of T cells are generally believed to serve a complementary role in host surveillance. However, the ultimate niche of ␥␦ T cells in human immune system is still unclear.A variety of human diseases have been demonstrated to associate with a selective proliferation of blood ␥␦ T cells. It was observed that ␥␦ T-cell numbers increased in patients with tuberculosis 1 (TB) and in healthy individuals in contact with TB patients. 3 In human ehrlichiosis, ␥␦ T cells represented a majority of blood lymphocytes that accounted for as much as 97% of circulating T cells at early stage for about 2 weeks before returning to a normal ␣␤/␥␦ ratio. 4 In the "silent" periods of celiac disease where pathology was mildest, it was found that the number of ␥␦ T cells was higher, suggesting that these cells may ...

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Section: Discussionmentioning

confidence: 99%

Peripheral γδ T‐cell deficit in nasopharyngeal carcinoma

Zheng

Chua

et al. 2002

Intl Journal of Cancer

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“…It is possible that the elevated anti-LMP response in BL, NPC and RA is a consequence of impaired EBV-specific cytotoxic T cell immunity, which controls the numbers of EBV-infected normal B cells (Gaston et al, 1985;Moss et al, 1983;Whittle et al, 1984). In this regard it is interesting that the healthy donor ST who showed an exceptionally strong anti-LMP response in the IPIB assay in the present study (Table 3), has a deficient EBV-specific cytotoxic T cell response (Bejarano et al, 1987).…”

Section: Discussionmentioning

confidence: 99%

Characterization of the Serological Response in Man to the Latent Membrane Protein and the Six Nuclear Antigens Encoded by Epstein-Barr Virus

Rowe

Finke

Szigeti

et al. 1988

Journal of General Virology

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“…NPC patients possessed CTL precursors specific for EBV-LMP2 and EBV-specific T cell responses were detectable in patients, albeit at lower levels than in healthy controls (26,27). The point was whether they included responses to those viral proteins expressed in the tumor.…”

Section: Introductionmentioning

confidence: 99%