Epstein-Barr virus–positive nodal T/NK-cell lymphoma: an analysis of 15 cases with distinct clinicopathological features

Jeon, Yoon Kyung; Kim, Jo Heon; Sung, Ji Youn; Han, Jae Ho; Ko, Young Hyeh

doi:10.1016/j.humpath.2015.03.002

Cited by 57 publications

(60 citation statements)

References 16 publications

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“…8A-E) This has been described in several recent reports from Asia. [99][100][101] These lymphomas tend to occur in elderly individuals with generalised lymphadenopathy, frequent liver or spleen involvement, and sometimes arising in the setting of immunodeficiency. They usually show centroblast-like or pleomorphic morphology and lack the angiocentric pattern of extranodal NK/T-cell lymphoma.…”

Section: Anaplastic Large Cell Lymphomas Alk-negative (Alk-alcl)mentioning

confidence: 99%

Approach to nodal-based T-cell lymphomas

Leval

2020

Pathology

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Peripheral T-cell lymphomas (PTCLs) represent a heterogeneous group of uncommon malignancies derived from mature T cells and usually characterised by an aggressive clinical course. Their clinical presentation, localisation and pattern of dissemination are highly variable, but the majority of cases present as nodal diseases. The recently revised classification of lymphomas has incorporated many new molecular genetic data derived from gene expression profiling and next generation sequencing studies, which refine the definition and diagnostic criteria of several entities. Nevertheless, the distinction of PTCL from various reactive conditions, and the diagnosis of PTCL subtypes remains notably challenging. Here, an updated summary of the clinicopathological and molecular features of the most common nodal-based PTCLs (angioimmunoblastic T-cell lymphoma and other nodal lymphomas derived from follicular T helper cells, anaplastic large cell lymphomas and peripheral T-cell lymphoma, not otherwise specified) is presented. Practical recommendations in the diagnostic approach to nodal T-cell lymphoproliferations are presented, including indications for the appropriate use and interpretation of ancillary studies. Finally, we discuss commonly encountered diagnostic problems, including pitfalls and mimics in the differential diagnosis with various reactive conditions, and the criteria that allow proper identification of distinct PTCL entities.

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Section: Anaplastic Large Cell Lymphomas Alk-negative (Alk-alcl)mentioning

confidence: 99%

Approach to nodal-based T-cell lymphomas

Leval

2020

Pathology

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“…Some cases show extensive necrosis, many apoptotic bodies, and angiocentric growth patterns. The immunophenotype is as follows: CD3 + , CD8 + , TIA + , and granzyme B + [28]. …”

Section: Epstein-barr Virus–associated B-cell Lymphoproliferative Dismentioning

confidence: 99%

Epstein-Barr Virus–Associated Lymphoproliferative Disorders: Review and Update on 2016 WHO Classification

Kim

et al. 2017

J Pathol Transl Med

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Epstein-Barr virus (human herpesvirus-4) is very common virus that can be detected in more than 95% of the human population. Most people are asymptomatic and live their entire lives in a chronically infected state (IgG positive). However, in some populations, the Epstein-Barr virus (EBV) has been involved in the occurrence of a wide range of B-cell lymphoproliferative disorders (LPDs), including Burkitt lymphoma, classic Hodgkin’s lymphoma, and immune–deficiency associated LPDs (post-transplant and human immunodeficiency virus–associated LPDs). T-cell LPDs have been reported to be associated with EBV with a subset of peripheral T-cell lymphomas, angioimmunoblastic T-cell lymphomas, extranodal nasal natural killer/T-cell lymphomas, and other rare histotypes. This article reviews the current evidence covering EBV-associated LPDs based on the 2016 classification of the World Health Organization. These LPD entities often pose diagnostic challenges, both clinically and pathologically, so it is important to understand their unique pathophysiology for correct diagnoses and optimal management.

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“…The authors concluded that these lesions were best classified as EBV-positive PTCL, NOS. 19,20 In a report from the PTCL/NK-cell lymphoma workshop by Attygalle et al, 21 4 cases of nodal EBV-positive T-cell lymphoma were reported. These cases lacked the features of ENKTL and were distinguished from ENKTL by the workshop panel.…”

Section: Discussionmentioning

confidence: 99%

EBV-associated Peripheral T-Cell Lymphoma of Gastrointestinal Tract Presented With Widespread Chronic Inflammation: A Case Report

Uppal

Chodoff²,

Wang³

et al. 2017

Applied Immunohistochemistry &Amp; Molecular Morphology

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We report a case of Epstein-Barr virus (EBV)-associated T-cell lymphoma of gastrointestinal (GI) tract from a 70-year-old white woman who initially presented with a widespread GI inflammation and gastric obstruction. Initial biopsies of the GI tract showed severe chronic inflammation in the esophagus, stomach, and the small intestine. Celiac disease and inflammatory bowel disease were ruled out. The patient was treated with partial gastrectomy. Histology showed gastric wall thickening with EBV-positive, mixed lymphocytic and plasma cell infiltration in the mucosa, and thickening and fibrosis of the submucosa. She developed EBV-associated T-cell lymphoma of the GI tract one and a half years later and expired due to multiorgan failure. The T-cell lymphoma diffusely infiltrated the GI wall without forming a mass lesion. The lymphoma expressed EBV and cytotoxic molecules but lacked common features of extranodal natural killer/T-cell lymphoma nasal type, such as angioinvasion/angiodestruction, necrosis, or CD56 expression. Immunoglobulin heavy chain (IGH) gene and T-cell receptor-γ gene rearrangements and EBV-positive cells were detected at the early stage of the disease. While IGH clones were transient, T-cell clones and EBV-positive cells progressively increased over the disease course. We conclude that this case is best classified as EBV-associated peripheral T-cell lymphoma of GI tract. Age-related immune senescence may have contributed to the uncontrolled GI inflammation and subsequent transformation to T-cell lymphoma.

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Epstein-Barr virus–positive nodal T/NK-cell lymphoma: an analysis of 15 cases with distinct clinicopathological features

Cited by 57 publications

References 16 publications

Approach to nodal-based T-cell lymphomas

Approach to nodal-based T-cell lymphomas

Epstein-Barr Virus–Associated Lymphoproliferative Disorders: Review and Update on 2016 WHO Classification

EBV-associated Peripheral T-Cell Lymphoma of Gastrointestinal Tract Presented With Widespread Chronic Inflammation: A Case Report

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