Epstein-Barr Virus-positive Intestinal Diffuse Large B-cell Lymphoma in a Japanese Patient with Celiac Disease: First Reported Case and a Literature Review

Ishibashi, Hideki; Imakiire, So; Goto, Maki; Nomaru, Rhohei; Shibata, Mamoru; Matsuoka, Hiroo; Yasuda, Hiromi; Yamashima, Tomomi; Sakisaka, Hideto; Tanabe, Taro; Matsuoka, Satoshi; Kuno, Nobuaki; Abe, Koichi; Funakoshi, Sadahiro; Takamatsu, Yasushi; Hirai, Fumihito; Takeshita, Morishige

doi:10.2169/internalmedicine.7876-21

Intern. Med.

2022

DOI: 10.2169/internalmedicine.7876-21

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Epstein-Barr Virus-positive Intestinal Diffuse Large B-cell Lymphoma in a Japanese Patient with Celiac Disease: First Reported Case and a Literature Review

Hideki Ishibashi

So Imakiire

Maki Goto

et al.

Abstract: A 60-year-old Japanese woman was diagnosed with celiac disease (CeD) and treated with a gluten-free diet. For five years, she had a good clinical course. However, she complained of inappetence and nausea. Colonoscopy revealed ulcerative tumors in the terminal ileum. A histological examination of biopsy specimens from the ulcerative tumor showed diffuse infiltration of large atypical lymphocytes. Immunohistologically, the atypical lymphoid cells were positive for cluster of differentiation (CD)10 and CD20. Many… Show more

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2024

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Cited by 2 publications

References 19 publications

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The role of Epstein-Barr virus in autoimmune and autoinflammatory diseases

Borghol,

Bitar,

Hanna

et al. 2024

Critical Reviews in Microbiology

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The role of Epstein-Barr virus in autoimmune and autoinflammatory diseases

Borghol,

Bitar,

Hanna

et al. 2024

Critical Reviews in Microbiology

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Primary intestinal diffuse large B-cell lymphoma: novel insights and clinical perception

Chen,

Wang,

Liu

et al. 2024

Front. Oncol.

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BackgroundExtranodal Non-Hodgkin lymphoma (NHL) is more prevalent in the gastrointestinal (GI) tract than in other sites. This study aimed to explore the clinical features and prognostic factors of primary intestinal diffuse large B-cell lymphoma (PI-DLBCL), in order to provide new references for basic research and clinical diagnosis and treatment of the rare extranodal malignant lymphoma.MethodsThe clinical data of 88 patients with PI-DLBCL admitted to Fujian Medical University Union Hospital from June 2011 to June 2022 were retrospectively studied, the clinical and pathological features, diagnosis and treatment process and prognosis of PI-DLBCL were analyzed, and univariate and multivariate analysis of prognostic factors was carried out. The Kaplan-Meier method was used for survival analysis. Meanwhile, the latest literature from PubMed was retrieved to systematically discuss the research progress in the diagnosis and treatment of PI-DLBCL.ResultsAmong the 88 patients with PI-DLBCL included in this study, 60 cases were males (68.18%), 28 cases were females (31.82%), and 62 patients (70.45%) were complaining of abdominal pain, and the second most common clinical manifestation was changes in bowel habits in 16 (18.18%), with a median age of onset of 57 (17–82) years. The first-line treatment regimen was surgery combined with R-CHOP chemotherapy (56.82%). The median follow-up time was 72 (1–148) months, 51 (57.95%) of 88 patients with PI-DLBCL survived, 30 patients (34.09%) died, 7 patients (7.95%) were lost to follow-up, and the PFS rates of 1-year, 3-year and 5-year were 57.95%, 29.55% and 15.91%, and the OS rates of 1-year, 3-year and 5-year were 79.55%, 45.45% and 28.41%, respectively. The results of univariate Cox regression analysis showed that ECOG score, Lugano stage, B symptoms, IPI score, white blood cells, serum LDH, albumin, β2 microglobulin were the influencing factors of OS in PI-DLBCL patients, and ECOG score, Lugano stage, B symptoms, IPI score, white blood cells, serum LDH, albumin, β2 microglobulin were all the influencing factors of PFS in PI-DLBCL patients. The results of multivariate Cox analysis showed that Lugano stage may be an independent prognostic factor affecting OS and PFS in PI-DLBCL patients.ConclusionPI-DLBCL is more common in middle-aged and elderly men, clinical manifestations lack specificity, first-line treatment is mainly surgery combined with standard chemotherapy regimens. The Lugano stage may be an independent prognostic factor affecting OS and PFS in PI-DLBCL patients.

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Epstein-Barr Virus-positive Intestinal Diffuse Large B-cell Lymphoma in a Japanese Patient with Celiac Disease: First Reported Case and a Literature Review

Cited by 2 publications

References 19 publications

The role of Epstein-Barr virus in autoimmune and autoinflammatory diseases

The role of Epstein-Barr virus in autoimmune and autoinflammatory diseases

Primary intestinal diffuse large B-cell lymphoma: novel insights and clinical perception

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