Epstein-Barr virus persistence and reactivation in neuromyelitis optica

Masuda, Saeko; Mori, Masahiro; Arai, Kimihito; Uzawa, Akiyuki; Muto, Mayumi; Uchida, Toshihiro; Masuda, Hiroki; Kuwabara, Satoshi

doi:10.1136/jnnp-2014-308095

Cited by 32 publications

(18 citation statements)

References 28 publications

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“…Patients with MS are known to have an elevated antibody response to EBV proteins and peptides. 32 , 33 Significantly higher anti-EBNA-1 IgG antibody titers in patients with MS than in patients with NMOSD were found, 34 which is in line with our results. In addition, patients with RRMS had higher anti-myelin peptide reactivities than patients in both NMOSD subgroups.…”

Section: Discussionsupporting

confidence: 89%

Serum peptide reactivities may distinguish neuromyelitis optica subgroups and multiple sclerosis

Metz

Beißbarth

Ellenberger

et al. 2016

Neurol Neuroimmunol Neuroinflamm

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Objective:To assess in an observational study whether serum peptide antibody reactivities may distinguish aquaporin-4 (AQP4) antibody (Ab)–positive and -negative neuromyelitis optica spectrum disorders (NMOSD) and relapsing-remitting multiple sclerosis (RRMS).Methods:We screened 8,700 peptides that included human and viral antigens of potential relevance for inflammatory demyelinating diseases and random peptides with pooled sera from different patient groups and healthy controls to set up a customized microarray with 700 peptides. With this microarray, we tested sera from 66 patients with AQP4-Ab-positive (n = 16) and AQP4-Ab-negative (n = 19) NMOSD, RRMS (n = 11), and healthy controls (n = 20).Results:Differential peptide reactivities distinguished NMOSD subgroups from RRMS in 80% of patients. However, the 2 NMOSD subgroups were not well-discriminated, although those patients are clearly separated by their antibody reactivities against AQP4 in cell-based assays. Elevated reactivities to myelin and Epstein-Barr virus peptides were present in RRMS and to AQP4 and AQP1 peptides in AQP4-Ab-positive NMOSD.Conclusions:While AQP4-Ab-positive and -negative NMOSD subgroups are not well-discriminated by peptide antibody reactivities, our findings suggest that peptide antibody reactivities may have the potential to distinguish between both NMOSD subgroups and MS. Future studies should thus concentrate on evaluating peptide antibody reactivities for the differentiation of AQP4-Ab-negative NMOSD and MS.

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Section: Discussionsupporting

confidence: 89%

Serum peptide reactivities may distinguish neuromyelitis optica subgroups and multiple sclerosis

Metz

Beißbarth

Ellenberger

et al. 2016

Neurol Neuroimmunol Neuroinflamm

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“…Recently, anti-cardiolipin antibodies in NMO patients have been associated with greater antithrombin-III activity and d -dimer levels, a product of fibrin degradation, suggesting the involvement of thrombotic pathogenic mechanisms in this disorder ( 26 , 30 ). Moreover, several studies supported the association between NMO and various infections ( 31 – 33 ).…”

Section: Specificity and Similarities Of Thrombotic And Demyelinatingmentioning

confidence: 89%

Demyelinating and Thrombotic Diseases of the Central Nervous System: Common Pathogenic and Triggering Factors

et al. 2015

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“…Viral infections precede NMOSD in 15-35% of the cases, but their linkage with anti-AP4 antibodies is as yet unknown [2]. Among viral infections preceding NMOSD, the most common are VZV [6][7][8], mumps [9], HIV [10], and Epstein-Barr virus [11]. Possible mechanisms to explain the association of autoimmunity with virus infection are bystander activation, in which microbes damage AP4-rich tissue provoking the activation of AP4-specific T-and B-cells against the CNS or molecular mimicry, in which the activation of B-cells produces antibodies that recognize both microbial epitopes and self-epitopes [2].…”

Section: Discussionmentioning

confidence: 99%

Neuromyelitis Optica Spectrum Disorder Attack Triggered by Herpes Zoster Infection

Turco

Curti

Maffini

et al. 2020

Multiple Sclerosis International

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Neuromyelitis optica spectrum disorder is a severe autoimmune disease of the central nervous system characterized by recurrent inflammatory events primarily involving the optic nerves and spinal cord. Recently, a triggering role of infectious events in the development of NMOSD has been suggested. Varicella zoster virus is the most common viral infection involved, though the linkage with anti-aquaporin-4 antibodies is so far unknown. We report, to the best of our knowledge, the first pediatric case report about NMOSD relapse triggered by herpes zoster infection. The strict temporal relationship between VZV infection and NMO attacks seems to be more than simply due to chance; however, further reports are needed to be confirmed.

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Epstein-Barr virus persistence and reactivation in neuromyelitis optica

Abstract: Our results raise the hypothesis that persistent, active EBV replication is present in NMO, and may contribute to the immunological alterations that play a pathogenetic role in the disorder.

Cited by 32 publications

References 28 publications

Serum peptide reactivities may distinguish neuromyelitis optica subgroups and multiple sclerosis

Serum peptide reactivities may distinguish neuromyelitis optica subgroups and multiple sclerosis

Demyelinating and Thrombotic Diseases of the Central Nervous System: Common Pathogenic and Triggering Factors

Neuromyelitis Optica Spectrum Disorder Attack Triggered by Herpes Zoster Infection

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