Epstein-Barr Virus Infectious Mononucleosis Associated with Acute Acalculous Cholecystitis

Lagona, Evagelia; Sharifi, Farshad; Voutsioti, Aikaterini; Mavri, Antonia; Markouri, M.; Attilakos, Achilleas

doi:10.1007/s15010-007-6115-y

Cited by 43 publications

(38 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Only sixteen other patients with EBV-associated AAC have been previously reported, with our case being one of the first in North America. 5–15 Fortunately, AAC complicating the course of primary EBV infection is associated with a favorable outcome. 13 …”

Section: Discussionmentioning

confidence: 99%

Fever and Jaundice in a Previously Healthy Teenager

Say

Chaparro

Koning

et al. 2016

Clin Pediatr (Phila)

View full text Add to dashboard Cite

A previously healthy 14-year-old girl was transferred to our facility from an outside hospital with a 10-day history of nausea, malaise, intermittent fever (peak 39.5°C), and fatigue. In the 72 hours prior to admission, she had developed progressive yellowing of the skin and scleral icterus. She had not traveled recently and her immunizations were up-to-date. She denied being sexually active or using illicit substances. She was a well-developed Caucasian adolescent who on initial presentation appeared fatigued and jaundiced. Vital signs on admission were the following: temperature, 38.8°C; heart rate, 96 beats per minute; respiratory rate, 18 breaths per minute; and blood pressure, 112/58 mm Hg. Her physical examination revealed scleral icterus, pharyngeal erythema with tonsillar exudates, anterior cervical lymphadenopathy, and right-sided abdominal tenderness. The liver edge was palpable at 1 cm below the right costal margin.Laboratory evaluation from the outside hospital revealed transaminase elevation and elevated serum bilirubin levels (Table 1). Complete blood count did not demonstrate evidence of anemia, thrombocytopenia, leukocytosis, or bandemia. Lipase level was normal at 32 U/L (23-300 U/L), though a C-reactive protein was mildly elevated at 1.20 mg/dL (<0.99 mg/ dL). Acetaminophen level was negative at <10.0 µg/ mL (10-25 µg/mL). Coagulation studies were within the reference range. An initial ultrasound of the abdomen showed diffuse thickening of the gallbladder wall, measuring up to 8.5 mm in thickness, with no evidence of biliary duct dilatation or the presence of stones (Figure 1). Splenomegaly was also seen. The patient did report right upper quadrant tenderness during the ultrasound, exhibiting the positive sonographic Murphy's sign. These findings were consistent with a working diagnosis of acute acalculous cholecystitis (AAC), and empiric broad-spectrum antibiotic therapy with piperacillin-tazobactam was initiated. All oral feeds were held and aggressive intravenous hydration was initiated.

show abstract

Section: Discussionmentioning

confidence: 99%

Fever and Jaundice in a Previously Healthy Teenager

Say

Chaparro

Koning

et al. 2016

Clin Pediatr (Phila)

View full text Add to dashboard Cite

show abstract

“…Ultrasonografik görüntülemede safra kesesi duvar kalınlıkları 4,2-19 mm arası bildirilmiştir. Bu hastaların genel özellikleri Tablo I'de özetlenmiştir (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Hastamız da bu komplikasyonun nadir görüldüğü yaş grubundaydı.…”

Section: Discussionunclassified

A Rare Comlication of Ebstein-Barr Virus Infection: Acalculous Cholecystitis

Ocak¹,

Akçaboy²,

Çakmakçı³

et al. 2016

jpr

View full text Add to dashboard Cite

GirişErken çocukluk döneminde Ebstein-Barr virüs (EBV) enfeksiyonu genellikle subklinik veya viral üst solunum yolu enfeksiyonunu taklit eden belirtilerle seyreder. Ancak geç çocukluk ve adölesan döneminde ateş, tonsillit ve lenf bezlerinde şişlikle karakterize enfeksiyöz mononükleoz klinik tablosuna yol açabilir. EBV kendi kendini sınırlayan bir enfeksiyon olmakla birlikte çok çeşitli komplikasyonlar bildirilmiştir. Hepatitle beraber hafif serum transaminaz yüksekliği sık görülen bulgu olsa da çocuklarda EBV ilişkili akut akalkülöz kolesistit (AAK) nadiren bildirilmiştir (1). Burada EBV enfeksiyonu sırasında gelişen ve seyrinde sorunsuz iyileşen bir akalkülöz kolesistit olgusu sunulmuştur. Olgu Sunumuİki yaşında erkek hasta iki gündür devam eden ateş, göz çevresinde ve karında şişlik şikayetleri ile başvurdu. Özgeçmiş ve soy geçmişinde özellik yoktu. Fizik incelemesinde genel ÖzABS TRACT Ebstein-Barr virüs (EBV) enfeksiyonu adölesan dönemde ateş, tonsillit, lenfadenit şeklinde seyreden enfeksiyöz mononükleoz tablosuna yol açsa da erken çocukluk döneminde enfeksiyon genellikle subklinik seyreder. EBV enfeksiyonu sırasında karaciğer enzim yüksekliği alışılmış bir bulgudur ancak akut akalkülöz kolesistit (AAK) nadir görülür. Burada akut EBV enfeksiyonu seyrinde gelişen AAK olgusu sunulmuştur. Hekimler EBV'ye bağlı gelişen enfeksiyoz mononükleoz seyri sırasında akut kolesistit gelişebileceğini, klinik iyileşmeye paralel olarak bu komplikasyonun düzeleceğini akılda bulundurmalıdır. Anahtar Kelimeler: Akut akalkülöz kolesistit, Ebstein-Bar virüs, çocuk Infection with Ebstein-Barr virüs (EBV) causes clinical signs such as fever, tonsillitis, lymphadenitis in adolescents, whereas it is mainly asymptomatic during early childhood. Elevations in liver function tests are known signs in EBV infection but acute acalculous cholecystitis (AAC) is rare. Herein, we report AAC in the course of acute EBV infection. Physicians should keep in mind that acute cholecystitis may develop during the course of EBV related infectious mononucleosis and this complication will recover-paralel to the clinical improvement of the primary disease.

show abstract

“…Researchers have postulated high concentrations of enzyme-inhibiting autoantibodies against the antioxidative enzyme, manganese-superoxide dismutase, play a role in cholestasis, but limited support exists for this idea [2]. Some cases, reported in the international literature, show an acute acalculous cholecystitis with EBV infection [8][9][10]. Clinicians have recently recognized EBV-induced hepatitis as an important cause of cholestasis [11].…”

Section: Discussionmentioning

confidence: 99%

A Case of Epstein-Barr Virus Infection with Gall Bladder and Common Bile Duct Stones in an Otherwise Healthy Child

Park

Noh

Park

et al. 2012

Pediatr Gastroenterol Hepatol Nutr

View full text Add to dashboard Cite

Cholelithiasis and choledocholithiasis are uncommon pediatric diseases, although clinicians have seen them with increasing frequency in children in recent years. Moreover, no case of Epstein-Barr virus (EBV) infection with cholelithiasis and choledocholithiasis has been previously reported in the English literature. We report a pediatric patient with EBV infection, a gall bladder stone, and a common bile duct stone, may have had GB and CBD stones prior to her EBV infection, whom we successfully treated with antibiotics and laparoscopic cholecystectomy for cholecystitis.

show abstract

Epstein-Barr Virus Infectious Mononucleosis Associated with Acute Acalculous Cholecystitis

Cited by 43 publications

References 6 publications

Fever and Jaundice in a Previously Healthy Teenager

Fever and Jaundice in a Previously Healthy Teenager

A Rare Comlication of Ebstein-Barr Virus Infection: Acalculous Cholecystitis

A Case of Epstein-Barr Virus Infection with Gall Bladder and Common Bile Duct Stones in an Otherwise Healthy Child

Contact Info

Product

Resources

About