Epstein-Barr virus infection of the colon with inflammatory bowel disease

Yanai, Hideo; Shimizu, Norio; Nagasaki, Susumu; Mitani, Noriyuki; Okita, Kiwamu

doi:10.1016/s0002-9270(99)00204-x

Cited by 57 publications

(55 citation statements)

References 22 publications

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“…Cho et al [24] reported the same result that EBV was not associated with colorectal tumors. However, Yanai et al [23] found that EBV was detected in 63.6 % of Crohn's disease cases and 60 % of ulcerative colitis cases using in situ hybridization for EBV-encoded small RNA1 (EBER-1), indicating that EBV infection may be related to IBD colonic diseases. Ioachim et al [26] studied 15 cases of primary anorectal lymphoma in AIDS patients and compared them with 4 cases of anorectal lymphoma unrelated to AIDS.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Epstein-barr virus in Chinese colorectal tumors

Liu¹,

Ding²,

Li³

et al. 2003

WJG

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AIM:To elucidate the association of Epstein-Barr virus (EBV) with colorectal tumors and to demonstrate whether infection of EBV existed in different stages of colorectal tumors involves in the carcinogenesis. METHODS:One hundred and thirty paraffin-embedded tissues of colorectal tumors were classified into 5 groups: 26 adenomas, 23 adenomas complicated with dysplasia, 22 adenomas complicated with carcinomatous, 36 colon carcinoma and 23 HNPCC, were examined by PCR, IHC and ISH, respectively. RESULTS: EBV DNA was detected by PCR in 26 cases out of the 130 specimens, including 5 cases of adenomas, 5 adenomas complicated with dysplasia, 5 adenomas complicated with carcinomatous, 7 colorectal carcinoma and 4 HNPCC. IHC detection showed the expression of LMP1 in 7 cases, including 1 adenoma, 1 adenoma with dysplasia, 1 HNPPC, 2 adenomas complicated with carcinomatous, and 2 colorectal carcinomas. The expression of EBER1 detected by ISH was positive in 6 cases, including 1 adenoma with dysplasia, 2 adenomas complicated with carcinomatous and 3 colorectal carcinomas. There were no significant differences among the results of PCR, IHC and ISH in the 5 groups. In all cases of HNPCC, none of the tumor cells showed positive signals of EBER1, but some EBV-positive tumor infiltrating lymphocytes were found in 2 of 23 cases. CONCLUSION:Our results showed that infection of EBV exists in human colorectal tumors, which indicates that EBV may be involved in the carcinogenesis of colorectal tumors but does not play an important role. The mechanisms need to be clarified further.Liu HX, Ding YQ, Li X, Yao KT. Investigation of Epstein-barr virus in Chinese colorectal tumors.

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Section: Discussionmentioning

confidence: 99%

Investigation of Epstein-barr virus in Chinese colorectal tumors

Liu¹,

Ding²,

Li³

et al. 2003

WJG

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“…Interest in a potential etiopathogenic role of Virus de Epstein-Barr (VEB) in IBD arose when an increased number of B lymphocytes infected with VEB was found in mucosal samples from UC colons, and, to a lesser degree, in CD samples [98] . Epidemiological data indicate that frequency of infection is similar in IBD patients and healthy controls, both approximately 100% [99] .…”

Section: Virus De Epstein-barrmentioning

confidence: 99%

Pathogenesis of Crohn’s disease: Bug or no bug

Bosca-Watts

Tosca

Antón

et al. 2015

WJGP

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“…Patients with inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis (UC), display increased numbers of EBV-infected lymphocytes in their inflammatory mucosae (14,15). Immunosuppressive therapy in IBD patients can reactivate latent EBV infections, which can lead to enteropathy (16).…”

Section: Discussionmentioning

confidence: 99%

Epstein-Barr Virus-associated Enteropathy as a Complication of Infectious Mononucleosis Mimicking Peripheral T-cell Lymphoma

Tamura¹,

Maruyama²,

Maeshima³

et al. 2013

Intern. Med.

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A 32-year-old man presented with a fever. A laboratory examination detected atypical lymphocytes and liver enzyme elevation. The serological tests for Epstein-Barr virus (EBV) were consistent with an acute infection pattern. Computed tomograpy showed bowel wall thickening, and colonoscopy revealed numerous ulcerations. The histological findings from the biopsy specimens from the colon were consistent with peripheral T-cell lymphoma (PTCL), and in situ hybridization detected EBER-1 in the atypical lymphocytes. Because his clinical and endoscopic abnormalities improved without medication, we diagnosed the patient with EBVassociated enteropathy. We herein report a rare case of EBV-associated enteropathy that required careful differentiation from PTCL.

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Epstein-Barr virus infection of the colon with inflammatory bowel disease

Abstract: The limited presence of EBV-infected cells in the diseased areas of IBD colonic specimens indicated that EBV infection may be related to such diseases.

Cited by 57 publications

References 22 publications

Investigation of Epstein-barr virus in Chinese colorectal tumors

Investigation of Epstein-barr virus in Chinese colorectal tumors

Pathogenesis of Crohn’s disease: Bug or no bug

Epstein-Barr Virus-associated Enteropathy as a Complication of Infectious Mononucleosis Mimicking Peripheral T-cell Lymphoma

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