Epstein-Barr virus infection of renal proximal tubule cells: possible role in chronic interstitial nephritis

Becker, Joanne; Miller, Frederick J.; Nuovo, Gerard J.; Josepovitz, Christine; Schubach, William H.; Nord, Edward P.

doi:10.1172/jci7286

Cited by 78 publications

(66 citation statements)

References 43 publications

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“…Becker et al reported direct EBV infection in renal proximal tubular cells by in situ hybridization (ISH) in patients with idiopathic chronic tubulointerstitial nephritis (10). In our case, ISH EBER-1 did not detect the presence of EBV in the interstitium, but the finding of tubulointerstitial nephritis matched the previous reports.…”

Section: Discussionsupporting

confidence: 89%

An Adult Case of Fulminant Epstein-Barr Virus Infection with Acute Tubulointerstitial Nephritis

et al. 2012

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Section: Discussionsupporting

confidence: 89%

An Adult Case of Fulminant Epstein-Barr Virus Infection with Acute Tubulointerstitial Nephritis

et al. 2012

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“…Similar to the lung pathology in patients with IPF, another study supported the concept that viral infection of renal epithelial cells contributed to the pathogenesis of chronic interstitial nephritis with characteristic interstitial fibrosis (6). According to data obtained from these studies, we can conclude that chronic viral infection of epithelial cells may be a trigger for fibrogenesis in several organs, as well as in vessel wall.…”

Section: Author's Replysupporting

confidence: 61%

Microorgansims and valve tissue/ Demonstration of Chlamydophila pneumoniae, Mycoplasma pneumoniae, Cytomegalovirus, and Epstein-Barr virus in atherosclerotic coronary arteries, nonrheumatic calcific aortic and rheumatic stenotic mitral valves by polymerase chain reaction

Davutoğlu¹,

Ercan²,

Oylumlu³

2011

Anadolu Kardiyol Derg

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Editöre Mektuplar Letter to Editor 564The authors sought to evaluate the presence of two bacterial (C. pneumoniae and M. pneumoniae) and two viral (CMV and EBV) pathogens in heart valves extracted during surgery. They found out that C. pneumoniae, M. pneumoniae, and CMV were detected in patients with stenotic aortic and mitral valves and in patients with coronary atherosclerosis with similar frequencies. The most striking findings for us are the relatively high frequency of C. pneumoniae, M. pneumoniae and CMV in mitral valve tissue (21%, 7%, and 12% respectively). The underlying mechanism and the progression of chronic rheumatic valve disease are remained to be a dilemma in regard to pathophysiologic insight. At least but not last, we know that the chronic phase of rheumatic valve involvement is strongly associated with ongoing release of serum inflammatory mediators, which correlate with the severity of valve involvement, valve scarring and subsequent valve calcification (2, 3). However, the most intriguing question so far, remained to be as an unknown triggering factor for progression and ongoing inflammation. Now according to Bayram et al. (1) we can speculate that one of the triggering mechanisms for valve scarring and ongoing inflammation might be a coexistence of some bacteria or viral microorganism? Alternatively, is there a proactive role of those organisms in terms of fibrotic tissue progression? Although the study by Bayram et al. (1) is too preliminary and needs to be clarified with respect to a cause-effect relationship, the results excite us for shedding more information about what presence of in micro word of valve.We thank authors for whipping us for a little more questioning the etiology of rheumatic valve.

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“…In addition, data implicating a viral etiology in analogous diseases may be relevant to building this argument. Similar to the lung pathology in patients with IPF, chronic interstitial nephritis is characterized by interstitial fibrosis and a mononuclear cell infiltrate in the kidneys (2). In one study, EBV was found by in situ hybridization in the epithelium of the proximal renal tubules in nine of nine patients with this disease but in none of the controls (2).…”

Section: Discussionmentioning

confidence: 91%

“…Similar to the lung pathology in patients with IPF, chronic interstitial nephritis is characterized by interstitial fibrosis and a mononuclear cell infiltrate in the kidneys (2). In one study, EBV was found by in situ hybridization in the epithelium of the proximal renal tubules in nine of nine patients with this disease but in none of the controls (2). EBV colocalized with its cellular receptor in the proximal tubular epithelium, where the receptor is expressed.…”

Section: Discussionmentioning

confidence: 92%

Herpesvirus DNA Is Consistently Detected in Lungs of Patients with Idiopathic Pulmonary Fibrosis

Tang¹,

Johnson²,

Browning³

et al. 2003

J Clin Microbiol

282

245

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On the basis of earlier reports associating Epstein-Barr Virus (EBV) with half of the cases of idiopathic pulmonary fibrosis (IPF), we hypothesized that chronic infection with EBV or a closely related herpesvirus would be detected in all cases of IPF. We tested lung specimens from 33 IPF patients (8 patients with familial IPF and 25 patients with sporadic IPF) and 25 patients with other diseases as controls for the presence of eight herpesviruses using PCR-based techniques. One or more of four herpesviruses (cytomegalovirus [CMV], EBV, human herpesvirus 7 [HHV-7], and HHV-8) were detected in 32 of 33 (97%) subjects with IPF and in 9 of 25 (36%) controls (P < 0.0001). CMV, EBV, and HHV-8 were found more frequently in IPF patients than in controls (P < 0.05, P < 0.001, and P < 0.01 respectively). Two or more herpesviruses were detected in 19 of 33 (57%) IPF patients and in 2 of 25 (8%) controls (P < 0.001). Two or more herpesviruses and HHV-8 were found more frequently in patients with sporadic IPF than in patients with familial IPF (P < 0.05 for both comparisons), and CMV was found less frequently in patients with sporadic IPF than in patients with familial IPF (P < 0.05). Immunohistochemistry for EBV or HHV-8 antigen showed viral antigen primarily in airway epithelial cells. These data support the concept that a herpesvirus could be a source of chronic antigenic stimulation in IPF.

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Epstein-Barr virus infection of renal proximal tubule cells: possible role in chronic interstitial nephritis

Cited by 78 publications

References 43 publications

An Adult Case of Fulminant Epstein-Barr Virus Infection with Acute Tubulointerstitial Nephritis

An Adult Case of Fulminant Epstein-Barr Virus Infection with Acute Tubulointerstitial Nephritis

Microorgansims and valve tissue/ Demonstration of Chlamydophila pneumoniae, Mycoplasma pneumoniae, Cytomegalovirus, and Epstein-Barr virus in atherosclerotic coronary arteries, nonrheumatic calcific aortic and rheumatic stenotic mitral valves by polymerase chain reaction

Herpesvirus DNA Is Consistently Detected in Lungs of Patients with Idiopathic Pulmonary Fibrosis

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