Epstein-Barr Virus Infection and Antibody Synthesis in Patients With Multiple Sclerosis

Bray, Patrick F.; Bloomer, Linda C.; Salmon, Valérie; Bagley, Mark; Larsen, Paul D.

doi:10.1001/archneur.1983.04050070036006

Cited by 128 publications

(90 citation statements)

References 10 publications

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“…Elevated levels of IgG to other viruses have been described in relation to MS. [23][24][25] We therefore tested the serologic response to other herpesviruses (CMV and VZV) and measles (another ubiquitous virus). Although antibodies to other viruses were elevated in some subjects, the levels were not found to correlate with EBNA-1 IgG or with presence of Gd ϩ lesions, suggesting that hyperresponsiveness of the immune response to EBV is specifically related to EBNA-1 IgG and-by inference-to the latent phase of the virus.…”

Section: Change In Edssmentioning

confidence: 99%

Humoral immune response to EBV in multiple sclerosis is associated with disease activity on MRI

Farrell

Antony²,

Wall³

et al. 2009

Neurology

186

164

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Section: Change In Edssmentioning

confidence: 99%

Humoral immune response to EBV in multiple sclerosis is associated with disease activity on MRI

Farrell

Antony²,

Wall³

et al. 2009

Neurology

186

164

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“…Overall, the evidence is insufficient to accept or reject the hypothesis that EBV increases subsequent risk of MS. A recent review concluded that there was evidence to support a role of EBV in the etiology of MS. Ascherio and Munch (44) evaluated studies comparing EBV serology in MS patients with controls, but did not examine the characteristics of the studies in detail. They concluded that the summary OR of MS comparing EBVseropositive individuals with EBV-seronegative individuals was 13.5 and that the strength of the association supported a role of EBV in MS. Several studies have demonstrated higher seroprevalence and higher antibody titres to other viruses, including measles, mumps and rubella (11,20,21). Elevated viral antibody titres have also been demonstrated in other disorders.…”

Section: Discussionmentioning

confidence: 99%

“…All five 'B' studies measuring serum titres found them to be higher among MS cases (11,17,21,23,24). This included the results of Shirodaria et al (21), who measured only serum titres.…”

Section: Seroepidemiologymentioning

confidence: 94%

“…Six of seven 'B' studies reported higher EBV seroprevalence among MS patients (Table 2) (11,(17)(18)(19)21,23,24). All five 'B' studies measuring serum titres found them to be higher among MS cases (11,17,21,23,24).…”

Section: Seroepidemiologymentioning

confidence: 96%

“…Fourteen seroepidemiological studies were identified (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24). Two of three studies by Sumaya et al (22,24) included data from a single patient series; so, only the latter of the two studies was included in the review.…”

Section: Seroepidemiologymentioning

confidence: 99%

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Multiple Sclerosis and Epstein-Barr Virus

Marrie

Wolfson

2002

Canadian Journal of Infectious Diseases

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OBJECTIVE:To evaluate the epidemiological evidence for an etiological role of Epstein-Barr virus in multiple sclerosis (MS). DATA SOURCES: MEDLINE and Cochrane Library searches of the medical literature identified 24 studies. DATA EXTRACTION: Studies were categorized as seroepidemiological, case-control or historical cohort, and were then classified within each group according to methodological rigour using criteria derived from published guidelines for the epidemiological study of MS. DATA SYNTHESIS: There was significant variability in the quality of evidence, and while two well-designed cohort studies found increased relative risks of MS in subjects with infectious mononucleosis, results from other studies were unconvincing. CONCLUSIONS: The evidence was insufficient to accept or reject the hypothesis that Epstein-Barr virus has an etiological role in MS. Further study, ideally using large samples of incident cases with blinded, trained interviewers using confirmatory sources for recalled data, is needed. EXTRACTION DES DONNÉES :Les études ont d'abord été divisées en trois catégories : séro-épidémiologiques, cas/témoins et cohortes antérieures, puis classées, dans chacun des groupes, en fonction de leur rigueur méthodologique selon des critères définis dans des lignes directrices publiées concernant l'étude épidémiologique de la SP. SYNTHÈSE DES DONNÉES : Des écarts importants ont été notés relativement à la qualité des données; deux études de cohortes, bien conçues, ont fait ressortir des risques relatifs accrus de SP chez les sujets ayant subi une mononucléose infectieuse, tandis que les résultats des autres études n'étaient pas concluants. CONCLUSION : Nous ne disposons pas suffisamment de données pour confirmer ou infirmer l'hypothèse selon laquelle le virus EpsteinBarr joue un rôle étiologique dans la SP. Il faudrait donc poursuivre l'étude, idéalement à partir de grands échantillons de cas nouveaux et en faisant appel à des intervieweurs formés et tenus dans l'ignorance, qui utilisent des sources de confirmation pour le rappel des données.

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