Epstein‐Barr virus in Hodgkin's disease patients in Japan

Abstract

The results of the current study, together with those reported previously, showed that the presence of the Epstein-Barr virus correlated with mixed cellularity type, age older than 40 years, and male sex.

Epstein–Barr virus and Hodgkin’s lymphoma in Cairo, Egypt

“…-Middle East (including Tunisia) [4][5][6][7][8][9][10][11][12]: between 28% of cases in a series from Jordan [12] and 70% of cases from Tunisia [4] were EBV-positive with HL; for Egypt [8], 50% were positive and 67% were of the NS type, which is similar to our findings -East Africa [13][14][15][16]: between 44% and 92% of cases were positive in Kenya -Central and South America [17][18][19][20][21][22][23]: between 31% of cases in Argentina [23] and 84% of cases in Peru [17] were positive -Asia [14,[24][25][26][27][28][29][30]: between 39% of cases in China [30] and 82% of cases in India [24] were positive, and the percentage of positive cases in most other countries was high (50% to 69%). For each country, the first column shows the number (n°) of cases studied whereas the other columns show the percentages of positive cases.…”

“…However, some cases showed scattered EBERpositive small lymphocytes, which are probably representative of the number of EBV-positive circulating (background) lymphocytes. In most of the studies reviewed, there was a low frequency of EBV in NLPHL [36,43,[45][46][47]; however, others reported a higher frequency, but only a few cases were studied [25,27,55]. NLPHL is now well defined by histological and immunohistochemical criteria under the WHO classification [2,3].…”

Epstein–Barr virus and Hodgkin’s disease: further evidence for the three disease hypothesis

“…30,[35][36][37][38] Data from studies investigating adult disease or non-selected series are less consistent but there are now several studies, from diverse geographical locales, which report similar age distributions of EBV-associated cases to the present study. 28,[39][40][41][42] The data provide biological support for the 'two-disease model' which suggests that HD in young and older adults has different aetiologies. 5,15 Furthermore, inclusion of the paediatric data provides support for MacMahon's hypothesis 1 which suggests that HD in children, young adults and older adults has different aetiologies.…”

Appearance of a different clone of Epstein–Barr virus genome in recurrent tumor of pyothorax-associated lymphoma (PAL) and a mini-review of PAL

“…EBER-1 oligonucleotide probe was labeled with digoxygenin and signals were developed with alkaline phosphatase-labeled anti-digoxygenin antibodies as previously described. 17 Sections treated with RNase before hybridization or probed with sense-oligonucleotide probe were used as negative controls for hybridization.…”